{"id":"https://openalex.org/W2096983604","doi":"https://doi.org/10.1093/jat/25.8.680","title":"Determination of Glufosinate Ammonium and its Metabolite, 3-Methylphosphinicopropionic Acid, in Human Serum by Gas Chromatography-Mass Spectrometry following Mixed-Mode Solid-Phase Extraction and t-BDMS Derivatization","display_name":"Determination of Glufosinate Ammonium and its Metabolite, 3-Methylphosphinicopropionic Acid, in Human Serum by Gas Chromatography-Mass Spectrometry following Mixed-Mode Solid-Phase Extraction and t-BDMS Derivatization","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2096983604","doi":"https://doi.org/10.1093/jat/25.8.680","mag":"2096983604","pmid":"https://pubmed.ncbi.nlm.nih.gov/11765024"},"language":"en","primary_location":{"id":"doi:10.1093/jat/25.8.680","doi":"https://doi.org/10.1093/jat/25.8.680","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jat/25.8.680","pdf_url":null,"source":{"id":"https://openalex.org/S140972820","display_name":"Journal of Analytical Toxicology","issn_l":"0146-4760","issn":["0146-4760","1945-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111676288","display_name":"Yasushi Hori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114838220","display_name":"Niigata University of Pharmacy and Medical and Life Sciences","ror":"https://ror.org/00dnbtf70","country_code":"JP","type":"education","lineage":["https://openalex.org/I114838220"]},{"id":"https://openalex.org/I4210108446","display_name":"Niigata City General Hospital","ror":"https://ror.org/01r8fpq52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108446"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasushi Hori","raw_affiliation_strings":["Department of Analytical Chemistry, Niigata College of Pharmacy, Japan. horiy@med.niigata-u.ac.jp","Department of Analytical Chemistry, Niigata College of Pharmacy, Niigata, Japan","Emergency and Critical Care Medical Center, Niigata City General Hospital, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Niigata College of Pharmacy, Japan. horiy@med.niigata-u.ac.jp","institution_ids":[]},{"raw_affiliation_string":"Department of Analytical Chemistry, Niigata College of Pharmacy, Niigata, Japan","institution_ids":["https://openalex.org/I114838220"]},{"raw_affiliation_string":"Emergency and Critical Care Medical Center, Niigata City General Hospital, Niigata, Japan","institution_ids":["https://openalex.org/I4210108446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050120968","display_name":"Manami Fujisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114838220","display_name":"Niigata University of Pharmacy and Medical and Life Sciences","ror":"https://ror.org/00dnbtf70","country_code":"JP","type":"education","lineage":["https://openalex.org/I114838220"]},{"id":"https://openalex.org/I4210108446","display_name":"Niigata City General Hospital","ror":"https://ror.org/01r8fpq52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108446"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manami Fujisawa","raw_affiliation_strings":["Department of Analytical Chemistry, Niigata College of Pharmacy, Niigata, Japan","Emergency and Critical Care Medical Center, Niigata City General Hospital, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Niigata College of Pharmacy, Niigata, Japan","institution_ids":["https://openalex.org/I114838220"]},{"raw_affiliation_string":"Emergency and Critical Care Medical Center, Niigata City General Hospital, Niigata, Japan","institution_ids":["https://openalex.org/I4210108446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035434845","display_name":"Kenji Shimada","orcid":"https://orcid.org/0000-0002-6670-3118","observed_orcids":["https://orcid.org/0000-0002-6670-3118"]},"institutions":[{"id":"https://openalex.org/I114838220","display_name":"Niigata University of Pharmacy and Medical and Life Sciences","ror":"https://ror.org/00dnbtf70","country_code":"JP","type":"education","lineage":["https://openalex.org/I114838220"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Shimada","raw_affiliation_strings":["Department of Analytical Chemistry, Niigata College of Pharmacy, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Niigata College of Pharmacy, Niigata, Japan","institution_ids":["https://openalex.org/I114838220"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109501880","display_name":"Yasuo Hirose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108446","display_name":"Niigata City General Hospital","ror":"https://ror.org/01r8fpq52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210108446"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuo Hirose","raw_affiliation_strings":["Emergency and Critical Care Medical Center, Niigata City General Hospital, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency and Critical Care Medical Center, Niigata City General Hospital, Niigata, Japan","institution_ids":["https://openalex.org/I4210108446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111676288"],"corresponding_institution_ids":["https://openalex.org/I114838220","https://openalex.org/I4210108446"],"apc_list":{"value":4823,"currency":"USD","value_usd":4823},"apc_paid":null,"fwci":1.8923,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.82540405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"25","issue":"8","first_page":"680","last_page":"684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.2687999904155731,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glufosinate-ammonium","display_name":"glufosinate ammonium","score":1.0},{"id":"https://openalex.org/keywords/human-serum","display_name":"human serum","score":0.6439999938011169},{"id":"https://openalex.org/keywords/mixed-mode-solid-phase-extraction","display_name":"mixed-mode solid-phase extraction","score":0.9300000071525574},{"id":"https://openalex.org/keywords/anion-exchange","display_name":"anion exchange","score":0.5600000023841858},{"id":"https://openalex.org/keywords/medical-toxicology","display_name":"clinical toxicology","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8692495822906494},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.7977515459060669},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7750672101974487},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7670022249221802},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6904067993164062},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.5879377722740173},{"id":"https://openalex.org/C81426234","wikidata":"https://www.wikidata.org/wiki/Q1408763","display_name":"Solid phase extraction","level":3,"score":0.5639069080352783},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5481624007225037},{"id":"https://openalex.org/C123460561","wikidata":"https://www.wikidata.org/wiki/Q677065","display_name":"Gas chromatography","level":2,"score":0.5370873808860779},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.47756391763687134},{"id":"https://openalex.org/C179302884","wikidata":"https://www.wikidata.org/wiki/Q7447710","display_name":"Selected ion monitoring","level":4,"score":0.4683510661125183},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06277340650558472}],"mesh":[{"descriptor_ui":"D000613","descriptor_name":"Aminobutyrates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000613","descriptor_name":"Aminobutyrates","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D000613","descriptor_name":"Aminobutyrates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002623","descriptor_name":"Chemistry Techniques, Analytical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011041","descriptor_name":"Poisoning","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062025","descriptor_name":"Organophosphate Poisoning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jat/25.8.680","doi":"https://doi.org/10.1093/jat/25.8.680","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jat/25.8.680","pdf_url":null,"source":{"id":"https://openalex.org/S140972820","display_name":"Journal of Analytical Toxicology","issn_l":"0146-4760","issn":["0146-4760","1945-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Toxicology","raw_type":"journal-article"},{"id":"pmid:11765024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11765024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of analytical toxicology","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W150424491","https://openalex.org/W172375007","https://openalex.org/W369708030","https://openalex.org/W1965759236","https://openalex.org/W1968493949","https://openalex.org/W2011824049","https://openalex.org/W2023908458","https://openalex.org/W2024950378","https://openalex.org/W2041195393","https://openalex.org/W2048351769","https://openalex.org/W2048809717","https://openalex.org/W2082261824","https://openalex.org/W2088037914","https://openalex.org/W2090334988","https://openalex.org/W2091064127","https://openalex.org/W3008832048"],"related_works":["https://openalex.org/W2066252212","https://openalex.org/W1965759236","https://openalex.org/W2896778355","https://openalex.org/W1964205491","https://openalex.org/W2090955682","https://openalex.org/W2051329978","https://openalex.org/W2912979962","https://openalex.org/W2125599910","https://openalex.org/W2382700808","https://openalex.org/W2595358843"],"abstract_inverted_index":{"A":[0],"method":[1,115,127,134],"for":[2],"the":[3,44,92,122],"analysis":[4,50],"of":[5,51,58,72,77,87,95,103],"glufosinate":[6],"ammonium":[7],"(GLUF)":[8],"and":[9,34,41,46,60,65,76,97],"its":[10],"metabolite":[11],"3-methylphosphinicopropionic":[12],"acid":[13],"(MPPA)":[14],"in":[15,143],"human":[16],"serum":[17,45,93,105],"by":[18,113],"gas":[19],"chromatography-mass":[20],"spectrometry":[21],"(GC-MS)":[22],"was":[23],"developed.":[24],"Employing":[25],"a":[26,139],"mixed-mode":[27],"cartridge":[28],"with":[29,109,118],"both":[30],"anion":[31],"exchange":[32],"action":[33],"weak":[35],"nonpolar":[36],"interaction,":[37],"we":[38],"extracted":[39],"GLUF":[40,59,75,96,110],"MPPA":[42,61,80,98],"from":[43,107,121],"carried":[47],"out":[48],"GC-MS":[49,133],"their":[52],"tert-butyldimethylsilyl":[53],"derivatives.":[54],"The":[55,84,131],"detection":[56],"limits":[57],"were":[62,81,99],"10":[63,78],"pg":[64,74,79],"1":[66],"pg,":[67],"respectively.":[68],"Full":[69],"mass":[70],"spectra":[71],"100":[73],"easily":[82],"obtainable.":[83],"recovery":[85],"rate":[86],"90.0+/-11.9%":[88],"(or":[89],"better)":[90],"when":[91],"concentrations":[94],"10-0.1":[100],"microg/mL.":[101],"Results":[102],"23":[104],"samples,":[106],"patients":[108],"poisoning,":[111],"measured":[112],"this":[114],"correlate":[116],"well":[117],"those":[119],"derived":[120],"conventional":[123],"high-performance":[124],"liquid":[125],"chromatography":[126],"(r":[128],"=":[129],"0.996).":[130],"developed":[132],"is":[135],"likely":[136],"to":[137],"become":[138],"useful":[140],"analytical":[141],"technique":[142],"clinical":[144],"settings.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}