{"id":"https://openalex.org/W2096962425","doi":"https://doi.org/10.1093/annonc/mdu465","title":"REBECA: a phase I study of bevacizumab and whole-brain radiation therapy for the treatment of brain metastasis from solid tumours","display_name":"REBECA: a phase I study of bevacizumab and whole-brain radiation therapy for the treatment of brain metastasis from solid tumours","publication_year":2014,"publication_date":"2014-10-02","ids":{"openalex":"https://openalex.org/W2096962425","doi":"https://doi.org/10.1093/annonc/mdu465","mag":"2096962425","pmid":"https://pubmed.ncbi.nlm.nih.gov/25274615"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdu465","doi":"https://doi.org/10.1093/annonc/mdu465","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdu465","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1093/annonc/mdu465","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049369439","display_name":"Christelle L\u00e9vy","orcid":"https://orcid.org/0000-0003-0572-5222","observed_orcids":["https://orcid.org/0000-0003-0572-5222"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C. L\u00e9vy","raw_affiliation_strings":["Department of Oncology. Electronic address: c.levy@baclesse.unicancer.fr","Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology. Electronic address: c.levy@baclesse.unicancer.fr","institution_ids":[]},{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046156275","display_name":"Djelila Allouache","orcid":"https://orcid.org/0009-0009-3693-3199","observed_orcids":["https://orcid.org/0009-0009-3693-3199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Allouache","raw_affiliation_strings":["Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048144414","display_name":"Jo\u00eblle Lacroix","orcid":"https://orcid.org/0009-0005-7956-7732","observed_orcids":["https://orcid.org/0009-0005-7956-7732"]},"institutions":[{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Lacroix","raw_affiliation_strings":["Department of Radiology, Centre Fran\u00e7ois Baclesse, Caen; Department of GIP Cyceron, Caen","Department of GIP Cyceron, Caen","Department of Radiology, Centre Fran\u00e7ois Baclesse, Caen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Centre Fran\u00e7ois Baclesse, Caen; Department of GIP Cyceron, Caen","institution_ids":["https://openalex.org/I4210121964","https://openalex.org/I4210154143"]},{"raw_affiliation_string":"Department of GIP Cyceron, Caen","institution_ids":["https://openalex.org/I4210154143"]},{"raw_affiliation_string":"Department of Radiology, Centre Fran\u00e7ois Baclesse, Caen","institution_ids":["https://openalex.org/I4210121964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108385094","display_name":"A. Dugu\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A.E. Dugu\u00e9","raw_affiliation_strings":["Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen","institution_ids":["https://openalex.org/I4210121964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042347658","display_name":"St\u00e9phane Supiot","orcid":"https://orcid.org/0000-0003-2094-1708","observed_orcids":["https://orcid.org/0000-0003-2094-1708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Supiot","raw_affiliation_strings":["Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071553983","display_name":"Mario Campone","orcid":"https://orcid.org/0000-0002-5196-5908","observed_orcids":["https://orcid.org/0000-0002-5196-5908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Campone","raw_affiliation_strings":["Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110936775","display_name":"Marc-Andr\u00e9 Mah\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106090","display_name":"Institut de Canc\u00e9rologie de l'Ouest","ror":"https://ror.org/01m6as704","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210106090"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Mahe","raw_affiliation_strings":["Department of Radiotherapy, Institut de Canc\u00e9rologie de l'Ouest Ren\u00e9 Gauducheau, Nantes-Saint Herblain, Caen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Institut de Canc\u00e9rologie de l'Ouest Ren\u00e9 Gauducheau, Nantes-Saint Herblain, Caen","institution_ids":["https://openalex.org/I4210106090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051042353","display_name":"Salim Kichou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Kichou","raw_affiliation_strings":["Department of Radiology, Centre Fran\u00e7ois Baclesse, Caen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Centre Fran\u00e7ois Baclesse, Caen","institution_ids":["https://openalex.org/I4210121964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079006574","display_name":"Marianne Leheurteur","orcid":"https://orcid.org/0000-0002-1952-4790","observed_orcids":["https://orcid.org/0000-0002-1952-4790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Leheurteur","raw_affiliation_strings":["Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010923467","display_name":"C. Hanzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152093","display_name":"Centre Henri Becquerel","ror":"https://ror.org/00whhby07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210141925","https://openalex.org/I4387152093"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Hanzen","raw_affiliation_strings":["Department of Radiotherapy, Centre Henri Becquerel, Rouen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Centre Henri Becquerel, Rouen","institution_ids":["https://openalex.org/I4387152093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056565799","display_name":"Veronique C Dieras","orcid":"https://orcid.org/0000-0001-8094-4738","observed_orcids":["https://orcid.org/0000-0001-8094-4738","https://orcid.org/0000-0002-8798-6540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Dieras","raw_affiliation_strings":["Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012593402","display_name":"Youlia Kirova","orcid":"https://orcid.org/0000-0002-1795-7509","observed_orcids":["https://orcid.org/0000-0002-1795-7509"]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Y. Kirova","raw_affiliation_strings":["Department of Radiotherapy, Institut Curie, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Institut Curie, Paris","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111032048","display_name":"F. Campana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Campana","raw_affiliation_strings":["Department of Radiotherapy, Institut Curie, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Institut Curie, Paris","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077744058","display_name":"\u00c9milie Le Rhun","orcid":"https://orcid.org/0000-0002-9408-3278","observed_orcids":["https://orcid.org/0000-0002-9408-3278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Le Rhun","raw_affiliation_strings":["Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108672124","display_name":"Louis Gras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131356","display_name":"Centre Oscar Lambret","ror":"https://ror.org/03xfq7a50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210131356","https://openalex.org/I4210141925"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L. Gras","raw_affiliation_strings":["Department of Radiotherapy, Centre Oscar Lambret, Lille"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Centre Oscar Lambret, Lille","institution_ids":["https://openalex.org/I4210131356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041410352","display_name":"Thomas Bachelot","orcid":"https://orcid.org/0000-0002-0866-9484","observed_orcids":["https://orcid.org/0000-0002-0866-9484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Bachelot","raw_affiliation_strings":["Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047514488","display_name":"Marie\u2010Pierre Sunyach","orcid":"https://orcid.org/0000-0002-9658-7656","observed_orcids":["https://orcid.org/0000-0002-9658-7656"]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M.-P. Sunyach","raw_affiliation_strings":["Department of Radiotherapy, Centre L\u00e9on B\u00e9rard, Lyon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Centre L\u00e9on B\u00e9rard, Lyon","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108930396","display_name":"Iona Hrab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Hrab","raw_affiliation_strings":["Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066201418","display_name":"Julien Geffrelot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Geffrelot","raw_affiliation_strings":["Department of Radiotherapy, Centre Fran\u00e7ois Baclesse, Caen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Centre Fran\u00e7ois Baclesse, Caen","institution_ids":["https://openalex.org/I4210121964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038830638","display_name":"K. Gunzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"K. Gunzer","raw_affiliation_strings":["Department of Oncology; Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen","Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen","Department of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology; Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen","institution_ids":["https://openalex.org/I4210121964"]},{"raw_affiliation_string":"Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen","institution_ids":["https://openalex.org/I4210121964"]},{"raw_affiliation_string":"Department of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039116194","display_name":"Jean\u2010Marc Constans","orcid":"https://orcid.org/0000-0002-6751-4378","observed_orcids":["https://orcid.org/0000-0002-6751-4378"]},"institutions":[{"id":"https://openalex.org/I4210114068","display_name":"Centre Hospitalier Universitaire de Caen Normandie","ror":"https://ror.org/027arzy69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210114068"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.-M. Constans","raw_affiliation_strings":["Department of GIP Cyceron, Caen; Department of Radiology, Centre Hospitalier Universitaire, Caen","Department of GIP Cyceron, Caen","Department of Radiology, Centre Hospitalier Universitaire, Caen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of GIP Cyceron, Caen; Department of Radiology, Centre Hospitalier Universitaire, Caen","institution_ids":["https://openalex.org/I4210114068","https://openalex.org/I4210154143"]},{"raw_affiliation_string":"Department of GIP Cyceron, Caen","institution_ids":["https://openalex.org/I4210154143"]},{"raw_affiliation_string":"Department of Radiology, Centre Hospitalier Universitaire, Caen","institution_ids":["https://openalex.org/I4210114068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015165342","display_name":"Jean\u2010Michel Grellard","orcid":"https://orcid.org/0000-0001-7997-5027","observed_orcids":["https://orcid.org/0000-0001-7997-5027"]},"institutions":[{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J.-M. Grellard","raw_affiliation_strings":["Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen","institution_ids":["https://openalex.org/I4210121964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028829159","display_name":"B\u00e9n\u00e9dicte Clarisse","orcid":"https://orcid.org/0000-0002-0543-732X","observed_orcids":["https://orcid.org/0000-0002-0543-732X"]},"institutions":[{"id":"https://openalex.org/I4210121964","display_name":"Centre Fran\u00e7ois Baclesse","ror":"https://ror.org/02x9y0j10","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210121964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B. Clarisse","raw_affiliation_strings":["Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Centre Fran\u00e7ois Baclesse, Caen","institution_ids":["https://openalex.org/I4210121964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089570643","display_name":"Xavier Paolett\u00ed","orcid":"https://orcid.org/0000-0002-1250-0040","observed_orcids":["https://orcid.org/0000-0002-1250-0040"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"X. Paoletti","raw_affiliation_strings":["Department of Biostatistics, Institut Curie/Inserm U900, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Institut Curie/Inserm U900, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I80043"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5049369439"],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":3.6039,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.94364478,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"12","first_page":"2351","last_page":"2356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7850000262260437},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9950000047683716},{"id":"https://openalex.org/keywords/whole-brain-radiotherapy","display_name":"whole brain radiotherapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.7739999890327454},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8450000286102295},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.902999997138977},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.531000018119812},{"id":"https://openalex.org/keywords/recist-response","display_name":"RECIST response","score":0.7160000205039978},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9469584226608276},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.8556896448135376},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.8005416393280029},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.612792432308197},{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.5318560004234314},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4502588212490082},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4284239411354065},{"id":"https://openalex.org/C2994463257","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain cancer","level":3,"score":0.41234228014945984},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3497513234615326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29321610927581787},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23444139957427979},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18022358417510986}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/annonc/mdu465","doi":"https://doi.org/10.1093/annonc/mdu465","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdu465","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},{"id":"pmid:25274615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25274615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of oncology : official journal of the European Society for Medical Oncology","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:open-archive.highwire.org:annonc:25/12/2351","doi":null,"is_oa":false,"landing_page_url":"http://annonc.oxfordjournals.org/cgi/content/short/25/12/2351","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:open-archive.highwire.org:annonc:mdu465v1","doi":null,"is_oa":false,"landing_page_url":"http://annonc.oxfordjournals.org/cgi/content/short/mdu465v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:open-archive.highwire.org:annonc:mdu465v2","doi":null,"is_oa":false,"landing_page_url":"http://annonc.oxfordjournals.org/cgi/content/short/mdu465v2","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdu465","doi":"https://doi.org/10.1093/annonc/mdu465","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdu465","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1577231758","https://openalex.org/W1978041336","https://openalex.org/W2012945281","https://openalex.org/W2034017959","https://openalex.org/W2047930883","https://openalex.org/W2069510682","https://openalex.org/W2074813144","https://openalex.org/W2076424556","https://openalex.org/W2093464518","https://openalex.org/W2101528690","https://openalex.org/W2107529266","https://openalex.org/W2124736921","https://openalex.org/W2124790303","https://openalex.org/W2132697290","https://openalex.org/W2141173616","https://openalex.org/W2142167347","https://openalex.org/W2146628652","https://openalex.org/W2154982767","https://openalex.org/W2156330848","https://openalex.org/W2158721954","https://openalex.org/W2158728780","https://openalex.org/W2159711942","https://openalex.org/W2171500698","https://openalex.org/W2182961594","https://openalex.org/W2355495448","https://openalex.org/W2533301708"],"related_works":["https://openalex.org/W2906891434","https://openalex.org/W2252730008","https://openalex.org/W2336704471","https://openalex.org/W2984939580","https://openalex.org/W2947847167","https://openalex.org/W3156351027","https://openalex.org/W4399362769","https://openalex.org/W2092683697","https://openalex.org/W4390061379","https://openalex.org/W2024153488"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
