{"id":"https://openalex.org/W2096936601","doi":null,"title":"Expression of the Endostatin gene in epithelial ovarian cancer.","display_name":"Expression of the Endostatin gene in epithelial ovarian cancer.","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2096936601","mag":"2096936601","pmid":"https://pubmed.ncbi.nlm.nih.gov/11489819"},"language":"en","primary_location":{"id":"pmid:11489819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11489819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108585470","display_name":"K. Hata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405285000","display_name":"Shimane Medical University","ror":"https://ror.org/04kg5pk90","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828","https://openalex.org/I4405285000"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Hata","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Shimane Medical University, Izumo 693-8501, Japan. hata31@shimane-med.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Shimane Medical University, Izumo 693-8501, Japan. hata31@shimane-med.ac.jp","institution_ids":["https://openalex.org/I4405285000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065264517","display_name":"Ritsuto Fujiwaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Fujiwaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057005039","display_name":"Kentaro Nakayama","orcid":"https://orcid.org/0000-0002-3250-3097","observed_orcids":["https://orcid.org/0000-0002-3250-3097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Nakayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111706253","display_name":"K Miyazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Miyazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3966,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.8020656,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"8","first_page":"2405","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endostatin","display_name":"endostatin","score":1.0},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.859000027179718},{"id":"https://openalex.org/keywords/collagen-xviii","display_name":"collagen XVIII","score":0.7990000247955322},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.6029999852180481},{"id":"https://openalex.org/keywords/residual-tumor","display_name":"residual tumor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4749999940395355},{"id":"https://openalex.org/keywords/normal-ovary","display_name":"normal ovary","score":0.5519999861717224},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C75920679","wikidata":"https://www.wikidata.org/wiki/Q359012","display_name":"Endostatin","level":3,"score":0.9176889657974243},{"id":"https://openalex.org/C2776608385","wikidata":"https://www.wikidata.org/wiki/Q749637","display_name":"Corpus luteum","level":3,"score":0.5085934400558472},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5061981081962585},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.48556968569755554},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4752778112888336},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.4701880216598511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45251065492630005},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44855058193206787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4412015378475189},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4236557185649872},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40450677275657654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3919612765312195},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.3467225432395935},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30451229214668274},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.18578645586967468},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043169","descriptor_name":"Endostatins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043170","descriptor_name":"Collagen Type XVIII","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11489819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11489819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2096936601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11489819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1489780573","https://openalex.org/W1557349926","https://openalex.org/W1579297325","https://openalex.org/W1885134561","https://openalex.org/W1942713680","https://openalex.org/W1971553231","https://openalex.org/W1978139448","https://openalex.org/W1985804036","https://openalex.org/W1986432877","https://openalex.org/W2007245383","https://openalex.org/W2014053256","https://openalex.org/W2017869427","https://openalex.org/W2019326387","https://openalex.org/W2020058136","https://openalex.org/W2030821918","https://openalex.org/W2047333918","https://openalex.org/W2048293656","https://openalex.org/W2073308580","https://openalex.org/W2083574998","https://openalex.org/W2095654922","https://openalex.org/W2131798870","https://openalex.org/W2139913413","https://openalex.org/W2161659842","https://openalex.org/W2328421677","https://openalex.org/W2403231832"],"related_works":["https://openalex.org/W2351351419","https://openalex.org/W2246745076","https://openalex.org/W2385282022","https://openalex.org/W2391053475","https://openalex.org/W2367533127","https://openalex.org/W2348707727","https://openalex.org/W1998485988","https://openalex.org/W2353451690","https://openalex.org/W2403231832","https://openalex.org/W1903804625"],"abstract_inverted_index":{"Endostatin,":[0],"a":[1,15,269,287],"M(r)":[2],"20,000":[3],"COOH-terminal":[4],"fragment":[5],"of":[6,22,38,59,65,69,101,109,112,116,122,158,215,239,262,266,276,286],"collagen":[7],"XVIII,":[8],"is":[9],"currently":[10],"in":[11,25,35,107,129,141],"preclinical":[12],"development":[13,285],"as":[14],"novel":[16],"antiangiogenic":[17],"agent.":[18],"The":[19,99],"gene":[20,103,119,127,177,199,221,244,260],"expression":[21,104,128,222,245,261],"this":[23,263],"molecule":[24],"23":[26,77],"normal":[27,142],"ovaries":[28,143],"with":[29,144,175,197,218,241,256],"follicle":[30,145],"or":[31,146,225,231],"corpus":[32,147],"luteum":[33,148],"and":[34,51,93,160,166,190,280],"64":[36],"cases":[37,67,78],"epithelial":[39,277,292],"ovarian":[40,130,278,293],"cancer":[41,279],"(27":[42],"serous,":[43],"18":[44],"mucinous,":[45],"13":[46],"endometrioid,":[47],"4":[48],"clear":[49],"cell,":[50],"2":[52],"undifferentiated":[53],"carcinomas)":[54],"was":[55,105,136],"analyzed":[56],"by":[57],"PCR":[58],"RNA":[60],"after":[61],"reverse":[62],"transcription.":[63],"Seven":[64],"the":[66,110,113,117,123,213,216,228,248,259,274,284],"were":[68,172,193,203],"low":[70,242],"malignant":[71],"potential.":[72],"With":[73],"regard":[74,257],"to":[75,120,224,233,258,272,283],"staging,":[76],"had":[79,84,89,95],"stage":[80,85,90,96,162],"I":[81],"disease,":[82,87,92],"5":[83],"II":[86],"29":[88],"III":[91],"7":[94],"IV":[97],"disease.":[98],"level":[100],"endostatin":[102,118,176,198,220,243],"described":[106],"terms":[108],"ratio":[111],"relative":[114],"yield":[115],"that":[121,140,238],"beta2-microglobulin":[124],"gene.":[125],"Endostatin":[126],"cancers":[131],"(median,":[132,149],"0.14;":[133],"range,":[134,151],"0.02-1.11)":[135],"significantly":[137,173,195,235],"higher":[138],"than":[139,227,237,247],"0.08;":[150],"0.03-0.26;":[152],"P":[153,251],"=":[154,164,170,252],"0.009).":[155],"International":[156],"Federation":[157],"Gynecology":[159],"Obstetrics":[161],"(P":[163,169],"0.009)":[165],"residual":[167],"tumor":[168],"0.005)":[171],"associated":[174,196],"expression;":[178],"however,":[179],"other":[180],"clinicopathological":[181],"features":[182],"(e.g.,":[183],"patient":[184],"age":[185],"at":[186],"diagnosis,":[187],"histological":[188,191],"subtype,":[189],"grade)":[192],"not":[194],"expression.":[200],"Survival":[201],"data":[202],"available":[204],"for":[205,291],"all":[206],"patients.":[207],"Univariate":[208],"Cox":[209],"regression":[210],"analysis":[211],"showed":[212],"prognosis":[214],"patients":[217,240],"high":[219],"[equal":[223],"greater":[226],"median":[229,249],"(>":[230],"=0.14)]":[232],"be":[234],"worse":[236],"[less":[246],"(<0.14);":[250],"0.044].":[253],"Our":[254],"results":[255],"endogenous":[264],"inhibitor":[265],"angiogenesis":[267],"present":[268],"new":[270,288],"insight":[271],"understand":[273],"biology":[275],"may":[281],"lead":[282],"therapeutic":[289],"strategy":[290],"cancer.":[294]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
