{"id":"https://openalex.org/W2096903274","doi":"https://doi.org/10.1161/01.str.0000185669.60271.78","title":"Cerebral Blood Flow Thresholds for mRNA Synthesis After Focal Ischemia and the Effect of MK-801","display_name":"Cerebral Blood Flow Thresholds for mRNA Synthesis After Focal Ischemia and the Effect of MK-801","publication_year":2005,"publication_date":"2005-10-14","ids":{"openalex":"https://openalex.org/W2096903274","doi":"https://doi.org/10.1161/01.str.0000185669.60271.78","mag":"2096903274","pmid":"https://pubmed.ncbi.nlm.nih.gov/16224091"},"language":"en","primary_location":{"id":"doi:10.1161/01.str.0000185669.60271.78","doi":"https://doi.org/10.1161/01.str.0000185669.60271.78","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.0000185669.60271.78","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103487540","display_name":"Tatsushi Kamiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatsushi Kamiya","raw_affiliation_strings":["From the Department of Neurology, University of Tennessee Health Science Center, Memphis, Tenn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology, University of Tennessee Health Science Center, Memphis, Tenn","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024609150","display_name":"Michael Jacewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Jacewicz","raw_affiliation_strings":["From the Department of Neurology, University of Tennessee Health Science Center, Memphis, Tenn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology, University of Tennessee Health Science Center, Memphis, Tenn","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111645665","display_name":"Thaddeus S. Nowak","orcid":"https://orcid.org/0000-0002-8601-773X","observed_orcids":["https://orcid.org/0000-0002-8601-773X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thaddeus S. Nowak","raw_affiliation_strings":["From the Department of Neurology, University of Tennessee Health Science Center, Memphis, Tenn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology, University of Tennessee Health Science Center, Memphis, Tenn","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111456112","display_name":"William A. Pulsinelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Pulsinelli","raw_affiliation_strings":["From the Department of Neurology, University of Tennessee Health Science Center, Memphis, Tenn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology, University of Tennessee Health Science Center, Memphis, Tenn","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I160606119"],"apc_list":null,"apc_paid":null,"fwci":1.4336,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82610848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"36","issue":"11","first_page":"2463","last_page":"2467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.8460000157356262},{"id":"https://openalex.org/keywords/focal-cerebral-ischemia","display_name":"focal cerebral ischemia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ischemic-penumbra","display_name":"ischemic penumbra","score":0.7020000219345093},{"id":"https://openalex.org/keywords/immediate-early-gene-expression","display_name":"immediate early gene expression","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hsp72","display_name":"HSP72","score":0.9240000247955322},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8889999985694885},{"id":"https://openalex.org/keywords/stroke-neuroprotection","display_name":"stroke neuroprotection","score":0.718999981880188},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.5740000009536743},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cortical-activation","display_name":"cortical activation","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.742948055267334},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7048649191856384},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.6693044304847717},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.6563184261322021},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.596095860004425},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.5898688435554504},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.5495301485061646},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5099495649337769},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.506588339805603},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.492870569229126},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.46660324931144714},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.4211374819278717},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41253364086151123},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4120033085346222},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39518022537231445},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39362606406211853},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24149271845817566},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22251036763191223},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22246432304382324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19757413864135742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0871315598487854},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001776","descriptor_name":"Blood Circulation Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017781","descriptor_name":"Genes, Immediate-Early","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020768","descriptor_name":"Middle Cerebral Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.str.0000185669.60271.78","doi":"https://doi.org/10.1161/01.str.0000185669.60271.78","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.0000185669.60271.78","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:16224091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16224091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6453667982","display_name":null,"funder_award_id":"NS42267","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8728008081","display_name":"Brain cooling and reperfusion injury in stroke","funder_award_id":"R01NS042267","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G938707742","display_name":null,"funder_award_id":"NS 03346","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1977024578","https://openalex.org/W1978404200","https://openalex.org/W1978428462","https://openalex.org/W1983476241","https://openalex.org/W1984677476","https://openalex.org/W1990614299","https://openalex.org/W1997118370","https://openalex.org/W1998969072","https://openalex.org/W1999465707","https://openalex.org/W2005030233","https://openalex.org/W2012555960","https://openalex.org/W2017053170","https://openalex.org/W2040113888","https://openalex.org/W2044080029","https://openalex.org/W2046938559","https://openalex.org/W2047480541","https://openalex.org/W2048533614","https://openalex.org/W2048890514","https://openalex.org/W2051967974","https://openalex.org/W2053200671","https://openalex.org/W2053768195","https://openalex.org/W2054892333","https://openalex.org/W2056097378","https://openalex.org/W2059024314","https://openalex.org/W2060645936","https://openalex.org/W2067609952","https://openalex.org/W2072168198","https://openalex.org/W2073383715","https://openalex.org/W2073521129","https://openalex.org/W2075065958","https://openalex.org/W2079609158","https://openalex.org/W2080849355","https://openalex.org/W2088023851","https://openalex.org/W2089637422","https://openalex.org/W2090496549","https://openalex.org/W2093404320","https://openalex.org/W2094691824","https://openalex.org/W2132486539","https://openalex.org/W2161103092"],"related_works":["https://openalex.org/W7100877135","https://openalex.org/W1983476241","https://openalex.org/W2094691824","https://openalex.org/W2379322576","https://openalex.org/W7096088844","https://openalex.org/W2044080029","https://openalex.org/W2044839361","https://openalex.org/W2147741867","https://openalex.org/W1976093159","https://openalex.org/W2041045821"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"MK-801":[3,25,67,109,178,199,237],"is":[4],"a":[5,125],"noncompetitive":[6],"antagonist":[7],"of":[8,24,50,74,87,97,132,140,192,215,227,244],"N-methyl-d-aspartate":[9],"subtype":[10],"glutamate":[11],"receptors":[12],"with":[13,64,85],"protective":[14],"efficacy":[15],"in":[16,93,112,129,169,183,210,247],"experimental":[17],"stroke.":[18],"This":[19],"study":[20],"examined":[21],"the":[22,51,104,130,150,170,184,189,213,232,239,254],"impact":[23],"on":[26],"cerebral":[27,53,256],"blood":[28],"flow":[29],"(CBF)":[30],"and":[31,55,83,103,123,180,186,224,249],"its":[32],"relationship":[33],"to":[34,47,117,136,143,159,174,231],"gene":[35,88,167,202],"expression":[36,89,168,203,243],"changes":[37,90],"during":[38],"focal":[39],"ischemia.":[40],"METHODS:":[41],"Spontaneously":[42],"hypertensive":[43],"rats":[44],"were":[45],"subjected":[46],"surgical":[48],"occlusion":[49],"middle":[52,255],"artery":[54,59,257],"ipsilateral":[56,135],"common":[57],"carotid":[58],"after":[60,177,195],"30":[61,160],"minutes":[62],"pretreatment":[63],"5":[65],"mg/kg":[66],"or":[68],"saline":[69],"vehicle.":[70],"After":[71],"2.5":[72],"hours":[73],"ischemia,":[75],"regional":[76],"CBF":[77,111,151,211],"was":[78],"evaluated":[79,91],"by":[80,92,204],"[14C]iodoantipyrine":[81],"autoradiography":[82],"compared":[84],"distributions":[86],"situ":[94],"hybridization":[95,181],"detection":[96],"mRNAs":[98,146],"encoding":[99],"several":[100],"immediate-early":[101,166,245],"genes":[102,229,246],"stress":[105],"protein,":[106],"hsp72.":[107],"RESULTS:":[108],"increased":[110],"contralateral":[113],"cortex":[114,134,141,216],"from":[115,253],"93+/-15":[116],"187+/-37":[118],"mL/100":[119,161],"g":[120,162],"per":[121,163],"minute":[122],"produced":[124],"significant":[126],"25%":[127],"reduction":[128],"volume":[131,214],"ischemic":[133,219,233],"occlusion.":[137],"The":[138],"extent":[139],"failing":[142],"express":[144],"inducible":[145,228],"correspondingly":[147],"decreased,":[148],"but":[149],"threshold":[152],"for":[153],"mRNA":[154],"synthesis":[155],"remained":[156],"unchanged":[157],"(25":[158],"minute).":[164],"Widespread":[165],"neocortex":[171],"became":[172],"restricted":[173],"periinfarct":[175],"regions":[176,251],"treatment,":[179],"patterns":[182],"striatum":[185],"hippocampus":[187],"reflected":[188],"altered":[190],"topography":[191],"cortical":[193,248],"activation":[194],"drug":[196],"treatment.":[197],"CONCLUSIONS:":[198],"alters":[200],"ischemia-induced":[201],"2":[205],"distinct":[206],"mechanisms.":[207],"Generalized":[208],"increases":[209],"reduce":[212],"falling":[217],"below":[218],"injury":[220],"thresholds,":[221],"protecting":[222],"tissue":[223],"facilitating":[225],"transcription":[226],"proximal":[230],"focus.":[234],"In":[235],"addition,":[236],"attenuates":[238],"signals":[240],"that":[241],"induce":[242],"subcortical":[250],"remote":[252],"territory.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}