{"id":"https://openalex.org/W2096866437","doi":"https://doi.org/10.1128/jvi.70.9.5852-5859.1996","title":"The CR1 and CR3 domains of the adenovirus type 5 E1A proteins can independently mediate activation of ATF-2","display_name":"The CR1 and CR3 domains of the adenovirus type 5 E1A proteins can independently mediate activation of ATF-2","publication_year":1996,"publication_date":"1996-09-01","ids":{"openalex":"https://openalex.org/W2096866437","doi":"https://doi.org/10.1128/jvi.70.9.5852-5859.1996","mag":"2096866437","pmid":"https://pubmed.ncbi.nlm.nih.gov/8709204","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/190602"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.70.9.5852-5859.1996","doi":"https://doi.org/10.1128/jvi.70.9.5852-5859.1996","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.70.9.5852-5859.1996","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC190602","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048751991","display_name":"Monique C.A. Duyndam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M C Duyndam","raw_affiliation_strings":["Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015796005","display_name":"Hans van Dam","orcid":"https://orcid.org/0000-0002-8307-4325","observed_orcids":["https://orcid.org/0000-0002-8307-4325"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H van Dam","raw_affiliation_strings":["Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109891856","display_name":"A.J. van der Eb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A J van der Eb","raw_affiliation_strings":["Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061373439","display_name":"Alt ZANTEMA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A Zantema","raw_affiliation_strings":["Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden University, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I121797337"],"apc_list":null,"apc_paid":null,"fwci":0.6365,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.61917094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"70","issue":"9","first_page":"5852","last_page":"5859"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.3490999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.3490999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.23280000686645508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.05339999869465828,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-type-5","display_name":"adenovirus type 5","score":0.9049999713897705},{"id":"https://openalex.org/keywords/e1a-protein","display_name":"E1A protein","score":0.890999972820282},{"id":"https://openalex.org/keywords/atf2","display_name":"ATF2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.7009999752044678},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/c-jun-promoter","display_name":"c-jun promoter","score":0.699999988079071},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/threonine-phosphorylation","display_name":"threonine phosphorylation","score":0.824999988079071},{"id":"https://openalex.org/keywords/cell-type-dependence","display_name":"cell type dependence","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6768045425415039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5734789371490479},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.4672785997390747},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44854962825775146},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43744632601737976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1851481795310974},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1736137568950653}],"mesh":[{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000260","descriptor_name":"Adenoviruses, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016350","descriptor_name":"Leucine Zippers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016758","descriptor_name":"Genes, jun","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017500","descriptor_name":"Adenovirus E1A Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017500","descriptor_name":"Adenovirus E1A Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051698","descriptor_name":"Activating Transcription Factor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/jvi.70.9.5852-5859.1996","doi":"https://doi.org/10.1128/jvi.70.9.5852-5859.1996","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.70.9.5852-5859.1996","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:236766","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC190602","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:8709204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8709204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:190602","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC190602/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.984.8589","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.984.8589","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/70/9/5852.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:236766","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC190602","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W49383898","https://openalex.org/W161079426","https://openalex.org/W292063008","https://openalex.org/W1542161618","https://openalex.org/W1555489233","https://openalex.org/W1580129093","https://openalex.org/W1604033113","https://openalex.org/W1692197226","https://openalex.org/W1747895236","https://openalex.org/W1749711544","https://openalex.org/W1762351857","https://openalex.org/W1768364897","https://openalex.org/W1792129397","https://openalex.org/W1843163606","https://openalex.org/W1964337986","https://openalex.org/W1966063731","https://openalex.org/W1982284863","https://openalex.org/W1984665850","https://openalex.org/W1984903682","https://openalex.org/W1989969910","https://openalex.org/W2003962192","https://openalex.org/W2003969944","https://openalex.org/W2007754578","https://openalex.org/W2010605653","https://openalex.org/W2014222675","https://openalex.org/W2023593713","https://openalex.org/W2026951979","https://openalex.org/W2027874507","https://openalex.org/W2033529039","https://openalex.org/W2035762638","https://openalex.org/W2037777120","https://openalex.org/W2055162988","https://openalex.org/W2055490337","https://openalex.org/W2057058623","https://openalex.org/W2068446924","https://openalex.org/W2077880395","https://openalex.org/W2083522684","https://openalex.org/W2094807913","https://openalex.org/W2106977971","https://openalex.org/W2125535264","https://openalex.org/W2126726971","https://openalex.org/W2127199932","https://openalex.org/W2137059153","https://openalex.org/W2140147801","https://openalex.org/W2269410728","https://openalex.org/W2333540356","https://openalex.org/W2406805804","https://openalex.org/W2417585883","https://openalex.org/W2432170829"],"related_works":["https://openalex.org/W109375810","https://openalex.org/W2948237174","https://openalex.org/W2048888448","https://openalex.org/W2094807913","https://openalex.org/W1749711544","https://openalex.org/W1692197226","https://openalex.org/W2411457167","https://openalex.org/W2124528320","https://openalex.org/W1747895236","https://openalex.org/W2127835664"],"abstract_inverted_index":{"The":[0,20],"adenovirus":[1],"12S":[2,54,56,96,208],"E1A":[3,57,97,108,209],"protein":[4,170],"can":[5,58,113],"stimulate":[6],"the":[7,10,42,46,50,60,64,77,81,91,103,106,127,150,158],"activity":[8,62,79,192],"of":[9,45,63,67,80,90,105,118,134,141,152,161,183,205,214],"c-jun":[11],"promoter":[12],"through":[13],"a":[14,72],"conserved":[15],"region":[16],"1":[17],"(CR1)-dependent":[18],"mechanism.":[19],"effect":[21],"is":[22,49,85,98],"mediated":[23],"by":[24,95,136,168,207,219],"two":[25],"AP-1/ATF-like":[26],"elements,":[27],"jun1":[28],"and":[29,111,120,155,186,217],"jun2,":[30],"that":[31,41,202],"preferentially":[32],"bind":[33],"c-Jun-ATF-2":[34,47],"heterodimers.":[35],"In":[36,102,130,173],"this":[37,176],"study,":[38],"we":[39,178],"show":[40],"ATF-2":[43,68,92,135,142,206],"component":[44],"heterodimer":[48],"primary":[51],"target":[52],"for":[53,166],"E1A:":[55],"enhance":[59],"transactivating":[61,78],"N":[65,83,93,159],"terminus":[66,84,94,160],"when":[69],"fused":[70],"to":[71,116,132,146],"heterologous":[73],"DNA-binding":[74],"domain,":[75],"whereas":[76],"c-Jun":[82],"not":[86,145,180,211],"significantly":[87],"affected.":[88],"Activation":[89],"dependent":[99,125],"on":[100,126,149],"CR1.":[101],"context":[104],"13S":[107],"protein,":[109],"CR1":[110],"CR3":[112],"both":[114],"contribute":[115],"activation":[117,133,140,204],"ATF-2,":[119,162],"their":[121],"relative":[122],"contributions":[123],"are":[124,164],"cell":[128,197],"type.":[129],"contrast":[131],"stress-inducing":[137],"agents,":[138],"CR1-dependent":[139,203],"was":[143],"found":[144],"depend":[147],"strictly":[148],"presence":[151],"threonines":[153,184,215],"69":[154,185,216],"71":[156,187,218],"in":[157,193],"which":[163],"targets":[165],"phosphorylation":[167,182,213],"stress-activated":[169],"kinases":[171],"(SAPKs).":[172],"agreement":[174],"with":[175],"observation,":[177],"did":[179],"observe":[181],"or":[188],"constitutively":[189],"enhanced":[190],"SAPK":[191],"E1A-":[194],"plus":[195],"E1B-transformed":[196],"lines.":[198],"These":[199],"data":[200],"suggest":[201],"does":[210],"require":[212],"SAPK.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
