{"id":"https://openalex.org/W2096861468","doi":"https://doi.org/10.1074/mcp.m500236-mcp200","title":"Regulation of Co-repressive Activity of and HDAC Recruitment to RIP140 by Site-specific Phosphorylation","display_name":"Regulation of Co-repressive Activity of and HDAC Recruitment to RIP140 by Site-specific Phosphorylation","publication_year":2005,"publication_date":"2005-08-10","ids":{"openalex":"https://openalex.org/W2096861468","doi":"https://doi.org/10.1074/mcp.m500236-mcp200","mag":"2096861468","pmid":"https://pubmed.ncbi.nlm.nih.gov/16093479"},"language":"en","primary_location":{"id":"doi:10.1074/mcp.m500236-mcp200","doi":"https://doi.org/10.1074/mcp.m500236-mcp200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m500236-mcp200","pdf_url":null,"source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/mcp.m500236-mcp200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064792308","display_name":"Pawan Kumar Gupta","orcid":"https://orcid.org/0000-0001-6692-7237","observed_orcids":["https://orcid.org/0000-0001-6692-7237"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pawan Gupta","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA","Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109996636","display_name":"M. D. Mostaqul Huq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. D. Mostaqul Huq","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071597606","display_name":"Shaukat Ali Khan","orcid":"https://orcid.org/0000-0001-7689-1258","observed_orcids":["https://orcid.org/0000-0001-7689-1258"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaukat Ali Khan","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024957372","display_name":"Nien\u2010Pei Tsai","orcid":"https://orcid.org/0000-0003-1032-0107","observed_orcids":["https://orcid.org/0000-0003-1032-0107"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nien-Pei Tsai","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034365665","display_name":"Li\u2010Na Wei","orcid":"https://orcid.org/0000-0002-6376-8506","observed_orcids":["https://orcid.org/0000-0002-6376-8506"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li-Na Wei","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034365665"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.1681,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.87300657,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"4","issue":"11","first_page":"1776","last_page":"1784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.6029999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.3244999945163727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rip140","display_name":"RIP140","score":0.9959999918937683},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.8809999823570251},{"id":"https://openalex.org/keywords/site-specific-phosphorylation","display_name":"site-specific phosphorylation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.5070000290870667},{"id":"https://openalex.org/keywords/protein-dephosphorylation","display_name":"protein dephosphorylation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/cofactor-recruitment","display_name":"cofactor recruitment","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7337720394134521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5920597910881042},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5286567211151123},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3296504616737366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2368474006652832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20094022154808044}],"mesh":[{"descriptor_ui":"D000078723","descriptor_name":"Nuclear Receptor Interacting Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/mcp.m500236-mcp200","doi":"https://doi.org/10.1074/mcp.m500236-mcp200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m500236-mcp200","pdf_url":null,"source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},{"id":"pmid:16093479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16093479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & cellular proteomics : MCP","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.319.3741","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.319.3741","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mcponline.org/content/4/11/1776.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/mcp.m500236-mcp200","doi":"https://doi.org/10.1074/mcp.m500236-mcp200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m500236-mcp200","pdf_url":null,"source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1122316658","display_name":"Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathways","funder_award_id":"R01DK060521","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3039475230","display_name":"Basic Research Center on Molecular and Cell Biology of Drug Abuse","funder_award_id":"P50DA011806","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7528625023","display_name":"Studies of Mouse Kappa Opioid Receptor Gene Regulation","funder_award_id":"R01DA011190","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8191673356","display_name":"TR2 nuclear receptor in vitamin A signaling","funder_award_id":"R01DK054733","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G901866320","display_name":"Studies of the Mouse Kappa Opioid Receptor Gene","funder_award_id":"K02DA013926","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1551142193","https://openalex.org/W1602722523","https://openalex.org/W1850214287","https://openalex.org/W1864394606","https://openalex.org/W1969973975","https://openalex.org/W1972172786","https://openalex.org/W1972732345","https://openalex.org/W1973120988","https://openalex.org/W1980870391","https://openalex.org/W1982186905","https://openalex.org/W1997835441","https://openalex.org/W2002120202","https://openalex.org/W2013232618","https://openalex.org/W2020808779","https://openalex.org/W2033366396","https://openalex.org/W2042629507","https://openalex.org/W2043957477","https://openalex.org/W2045663280","https://openalex.org/W2051152566","https://openalex.org/W2079003739","https://openalex.org/W2085677500","https://openalex.org/W2087236819","https://openalex.org/W2095561162","https://openalex.org/W2097490095","https://openalex.org/W2099246814","https://openalex.org/W2101073935","https://openalex.org/W2101298061","https://openalex.org/W2120853124","https://openalex.org/W2126975683","https://openalex.org/W2138778824","https://openalex.org/W2148720103","https://openalex.org/W2159044548","https://openalex.org/W2160894282","https://openalex.org/W2163188040","https://openalex.org/W2165923048"],"related_works":["https://openalex.org/W7096628308","https://openalex.org/W2126975683","https://openalex.org/W7096362738","https://openalex.org/W7097406469","https://openalex.org/W2045663280","https://openalex.org/W2013232618","https://openalex.org/W1973120988","https://openalex.org/W1963917140","https://openalex.org/W2054674119","https://openalex.org/W2101073935"],"abstract_inverted_index":{"Receptor":[0],"interacting":[1,182],"protein":[2,97],"140":[3],"(RIP140)":[4],"is":[5,157,190],"a":[6,27,77,152,161,222],"versatile":[7],"transcriptional":[8],"co-repressor":[9],"that":[10,227],"contains":[11],"several":[12],"autonomous":[13],"repressive":[14,102,120,137,179],"domains":[15],"(RDs).":[16],"The":[17,59,89,185,210],"N-terminal":[18,50,90],"RD":[19,51,91],"acts":[20],"by":[21,33,94],"recruiting":[22],"histone":[23],"deacetylases":[24],"(HDACs).":[25],"In":[26],"comprehensive":[28],"proteomic":[29],"analysis":[30],"of":[31,38,61,63,107,187,207,217,233],"RIP140":[32,39,64,150,177,208,218,234],"MS,":[34],"11":[35],"phosphorylation":[36,62,84,143,169,229],"sites":[37,45],"are":[40,46,74,87],"identified;":[41],"among":[42],"them":[43],"five":[44],"located":[47],"in":[48,65,163,204],"the":[49,71,95,136,164,193,215],"including":[52],"Ser104,":[53],"Thr202,":[54],"Thr207,":[55],"Ser358,":[56],"and":[57,70,122,135,173,180,202,236],"Ser380.":[58],"role":[60,199],"regulating":[66],"its":[67,101,119,132,238],"biological":[68,219],"activity":[69,103,121,186,220],"underlying":[72],"mechanism":[73],"examined":[75],"using":[76],"site-directed":[78],"mutagenesis":[79],"approach.":[80],"Mutations":[81,109],"mimicking":[82,110,141],"constitutive":[83,111,142,168],"or":[85,115,147],"dephosphorylation":[86,112],"introduced.":[88],"phosphorylation,":[92],"mediated":[93],"mitogen-activated":[96],"kinase":[98],"(MAPK),":[99],"enhances":[100],"through":[104,221],"increased":[105],"recruitment":[106,134],"HDAC.":[108,184],"at":[113,127,144,170,230],"Thr202":[114,146,172,201],"Thr207":[116,148,174,203],"significantly":[117],"impair":[118],"HDAC":[123,133],"recruitment,":[124],"whereas":[125],"mutation":[126],"Ser358":[128],"only":[129],"slightly":[130],"affects":[131],"activity.":[138],"Consistently,":[139],"mutations":[140],"either":[145],"convert":[149],"into":[151,214],"more":[153],"potent":[154],"repressor,":[155],"which":[156],"less":[158],"responsive":[159],"to":[160,192],"disturbance":[162],"MAPK":[165,194],"system.":[166],"Furthermore,":[167],"both":[171],"residues":[175,232],"renders":[176],"fully":[178],"strongly":[181],"with":[183],"this":[188],"mutant":[189],"resistant":[191],"inhibitor,":[195],"indicating":[196],"an":[197],"essential":[198],"for":[200],"MAPK-mediated":[205],"modulation":[206,216],"function.":[209],"study":[211],"provides":[212],"insights":[213],"specific":[223,231],"cellular":[224],"signaling":[225],"pathway":[226],"augments":[228],"molecule":[235],"alters":[237],"cofactor":[239],"recruitment.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}