{"id":"https://openalex.org/W2096796935","doi":"https://doi.org/10.1186/1465-9921-12-129","title":"Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trial","display_name":"Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trial","publication_year":2011,"publication_date":"2011-09-28","ids":{"openalex":"https://openalex.org/W2096796935","doi":"https://doi.org/10.1186/1465-9921-12-129","mag":"2096796935","pmid":"https://pubmed.ncbi.nlm.nih.gov/21955733","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3190346"},"language":"en","primary_location":{"id":"doi:10.1186/1465-9921-12-129","doi":"https://doi.org/10.1186/1465-9921-12-129","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1465-9921-12-129","pdf_url":"https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/1465-9921-12-129","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/1465-9921-12-129","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090459826","display_name":"Steven Kesten","orcid":"https://orcid.org/0000-0002-5522-7910","observed_orcids":["https://orcid.org/0000-0002-5522-7910"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven Kesten","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA. skesten@uptakemedical.com","Boehringer Ingelheim Pharmaceuticals, Ridgefield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA. skesten@uptakemedical.com","institution_ids":["https://openalex.org/I4210160255"]},{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Ridgefield, USA","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008555938","display_name":"Bartolom\u00e9 R. Celli","orcid":"https://orcid.org/0000-0002-7266-8371","observed_orcids":["https://orcid.org/0000-0002-7266-8371"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bartolome Celli","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, Massachusetts, USA","Brigham and Women s Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Brigham and Women s Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113606853","display_name":"Marc Decramer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marc Decramer","raw_affiliation_strings":["University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101983701","display_name":"Dacheng Liu","orcid":"https://orcid.org/0000-0002-3732-555X","observed_orcids":["https://orcid.org/0000-0002-3732-555X"]},"institutions":[{"id":"https://openalex.org/I4210160255","display_name":"Boehringer Ingelheim (United States)","ror":"https://ror.org/05kffp613","country_code":"US","type":"company","lineage":["https://openalex.org/I1330995197","https://openalex.org/I4210160255"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dacheng Liu","raw_affiliation_strings":["Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA","Boehringer Ingelheim Pharmaceuticals, Ridgefield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA","institution_ids":["https://openalex.org/I4210160255"]},{"raw_affiliation_string":"Boehringer Ingelheim Pharmaceuticals, Ridgefield, USA","institution_ids":["https://openalex.org/I4210160255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062711392","display_name":"Donald P. Tashkin","orcid":"https://orcid.org/0000-0002-5607-4872","observed_orcids":["https://orcid.org/0000-0002-5607-4872"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Tashkin","raw_affiliation_strings":["David Geffen School of Medicine UCLA, Los Angeles, California, USA","David Geffen School of Medicine, UCLA, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Geffen School of Medicine UCLA, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"David Geffen School of Medicine, UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090459826"],"corresponding_institution_ids":["https://openalex.org/I4210160255"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":3.2631,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.91846822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"129","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tiotropium","display_name":"tiotropium","score":0.8230000138282776},{"id":"https://openalex.org/keywords/uplift-trial","display_name":"UPLIFT trial","score":0.9210000038146973},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6990000009536743},{"id":"https://openalex.org/keywords/st-george-s-respiratory-questionnaire","display_name":"St George's Respiratory Questionnaire","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lung-function-decline","display_name":"lung function decline","score":0.5960000157356262},{"id":"https://openalex.org/keywords/patient-subgroups","display_name":"patient subgroups","score":0.4819999933242798},{"id":"https://openalex.org/keywords/natural-history-of-copd","display_name":"natural history of COPD","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7010809183120728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6161308884620667},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5477055311203003},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3697025775909424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3567647933959961}],"mesh":[{"descriptor_ui":"D000069447","descriptor_name":"Tiotropium Bromide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012602","descriptor_name":"Scopolamine Derivatives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012602","descriptor_name":"Scopolamine Derivatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1465-9921-12-129","doi":"https://doi.org/10.1186/1465-9921-12-129","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1465-9921-12-129","pdf_url":"https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/1465-9921-12-129","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3190346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3190346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respir Res","raw_type":"Text"},{"id":"pmid:21955733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21955733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory research","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:adb03b64a4c3483e98a24d9fc5d58479","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/adb03b64a4c3483e98a24d9fc5d58479","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Respiratory Research, Vol 12, Iss 1, p 129 (2011)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt2646v2dq","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2646v2dq","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Respiratory Research, vol 12, iss 1","raw_type":"article"},{"id":"pmh:qt2646v2dq","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/2646v2dq","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kesten, Steven; Celli, Bartolome; Decramer, Marc; Liu, Dacheng; & Tashkin, Donald. (2011). Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trial. Respiratory Research, 12(1), 129. doi: http://dx.doi.org/10.1186/1465-9921-12-129. Retrieved from: http://www.escholarship.org/uc/item/2646v2dq","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1465-9921-12-129","doi":"https://doi.org/10.1186/1465-9921-12-129","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1465-9921-12-129","pdf_url":"https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/1465-9921-12-129","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096796935.pdf","grobid_xml":"https://content.openalex.org/works/W2096796935.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1920721512","https://openalex.org/W1999226863","https://openalex.org/W2011295420","https://openalex.org/W2027967146","https://openalex.org/W2032080378","https://openalex.org/W2045749557","https://openalex.org/W2045827836","https://openalex.org/W2052977441","https://openalex.org/W2083436606","https://openalex.org/W2103809903","https://openalex.org/W2112162293","https://openalex.org/W2117837864","https://openalex.org/W2122786331","https://openalex.org/W2124884121","https://openalex.org/W2127951128","https://openalex.org/W2132128923","https://openalex.org/W2132565543","https://openalex.org/W2133119676","https://openalex.org/W2139347600","https://openalex.org/W2140932829","https://openalex.org/W2141034778","https://openalex.org/W2142724633","https://openalex.org/W2158553376","https://openalex.org/W2172071634","https://openalex.org/W2268275976","https://openalex.org/W2310176410","https://openalex.org/W2322866941","https://openalex.org/W2604596332","https://openalex.org/W4232710408","https://openalex.org/W4236132672","https://openalex.org/W4285719527","https://openalex.org/W4320288047"],"related_works":["https://openalex.org/W6920784531","https://openalex.org/W4302116676","https://openalex.org/W2884679252","https://openalex.org/W7097578231","https://openalex.org/W2054649248","https://openalex.org/W2609815990","https://openalex.org/W2203407764","https://openalex.org/W2114656103","https://openalex.org/W2613694640","https://openalex.org/W7099117472"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,88,121,158,180,206,256],"rate":[2,81],"of":[3,15,19,30,33,41,49,64,82,177,182,209,245,278],"decline":[4,83,246],"in":[5,9,54,85,112,127,217,247,250],"forced":[6],"expiratory":[7],"volume":[8],"1":[10,186,213],"second":[11],"(FEV1)":[12],"is":[13],"representative":[14],"the":[16,25,28,80,113,162,193,196,259,263,276],"natural":[17],"history":[18],"COPD.":[20],"Sparse":[21],"information":[22],"exists":[23],"regarding":[24],"associations":[26],"between":[27],"magnitude":[29],"annualised":[31,125],"loss":[32],"FEV1":[34,65,110,128],"with":[35,68,161,184,203,211,241,258,275],"other":[36,122],"endpoints.":[37],"METHODS:":[38],"Retrospective":[39],"analysis":[40],"UPLIFT\u00ae":[42],"trial":[43,48],"(four-year,":[44],"randomized,":[45],"double-blind,":[46],"placebo-controlled":[47],"tiotropium":[50],"18":[51],"\u03bcg":[52],"daily":[53],"chronic":[55],"obstructive":[56],"pulmonary":[57],"disease":[58,169],"[COPD],":[59],"n":[60],"=":[61,133,137,142,220,226],"5993).":[62],"Decline":[63],"was":[66,216,239],"analysed":[67],"random":[69],"co-efficient":[70],"regression.":[71],"Patients":[72,267],"were":[73,99],"categorised":[74],"according":[75],"to":[76,195,233,253,289],"quartiles":[77,123,274],"based":[78],"on":[79],"(RoD)":[84],"post-bronchodilator":[86,109],"FEV1.":[87],"St":[89],"George's":[90],"Respiratory":[91],"Questionnaire":[92],"(SGRQ)":[93],"total":[94],"score,":[95],"exacerbations":[96],"and":[97,140,152,172,229,236],"mortality":[98],"assessed":[100],"within":[101],"each":[102,254],"quartile.":[103,255],"RESULTS:":[104],"Mean":[105],"(standard":[106],"error":[107],"[SE])":[108],"increased":[111,202,249],"first":[114,234],"quartile":[115],"(Q1)":[116],"by":[117],"37":[118],"(1)":[119,139],"mL/year.":[120],"showed":[124,188],"declines":[126],"(mL/year)":[129],"as":[130],"follows:":[131],"Q2":[132],"24":[134],"(1),":[135],"Q3":[136],"59":[138],"Q4":[141,218,225],"125":[143],"(2).":[144],"Age,":[145],"gender,":[146],"respiratory":[147],"medication":[148],"use":[149],"at":[150,170],"baseline":[151,171],"SGRQ":[153,248],"did":[154],"not":[155],"distinguish":[156],"groups.":[157],"patient":[159],"subgroup":[160],"largest":[163,197,260],"RoD":[164,261,273],"had":[165,262],"less":[166],"severe":[167],"lung":[168],"contained":[173],"a":[174,189],"higher":[175],"proportion":[176,208,252],"current":[178],"smokers.":[179],"percentage":[181],"patients":[183,210],"\u2265":[185,212],"exacerbation":[187,200,215,235,238],"minimal":[190],"difference":[191],"from":[192],"lowest":[194],"RoD,":[198],"but":[199],"rates":[201],"increasing":[204,242],"RoD.":[205,243],"highest":[207,264],"hospitalised":[214,237],"(Q1":[219],"19.5%":[221],"[tiotropium],":[222],"26%":[223],"[control];":[224],"33.8%":[227],"[tiotropium]":[228],"33.1%":[230],"[control]).":[231],"Time":[232],"shorter":[240],"Rate":[244],"direct":[251],"group":[257],"mortality.":[265],"CONCLUSION:":[266],"can":[268],"be":[269,292],"grouped":[270],"into":[271],"different":[272,279],"observation":[277],"clinical":[280],"outcomes":[281],"indicating":[282],"that":[283],"specific":[284],"(or":[285],"more":[286],"aggressive)":[287],"approaches":[288],"management":[290],"may":[291],"needed.":[293],"TRIAL":[294],"REGISTRATION:":[295],"ClinicalTrials.gov":[296],"number,":[297],"NCT00144339.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}