{"id":"https://openalex.org/W2096773025","doi":"https://doi.org/10.1002/acr.22270","title":"Association Between Inflammatory Biomarkers and Bone Mineral Density in a Community\u2010Based Cohort of Men and Women","display_name":"Association Between Inflammatory Biomarkers and Bone Mineral Density in a Community\u2010Based Cohort of Men and Women","publication_year":2013,"publication_date":"2013-12-24","ids":{"openalex":"https://openalex.org/W2096773025","doi":"https://doi.org/10.1002/acr.22270","mag":"2096773025","pmid":"https://pubmed.ncbi.nlm.nih.gov/24375982","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4069198"},"language":"en","primary_location":{"id":"doi:10.1002/acr.22270","doi":"https://doi.org/10.1002/acr.22270","is_oa":false,"landing_page_url":"https://doi.org/10.1002/acr.22270","pdf_url":null,"source":{"id":"https://openalex.org/S13698240","display_name":"Arthritis Care & Research","issn_l":"0893-7524","issn":["0893-7524","1529-0123","2151-464X","2151-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Care &amp; Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4069198","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013148323","display_name":"Todd R. Sponholtz","orcid":"https://orcid.org/0000-0003-4647-5354","observed_orcids":["https://orcid.org/0000-0003-4647-5354"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd R. Sponholtz","raw_affiliation_strings":["Boston University, School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University, School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430543","display_name":"Xiaochun Zhang","orcid":"https://orcid.org/0000-0003-3297-2093","observed_orcids":["https://orcid.org/0000-0003-3297-2093"]},"institutions":[{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaochun Zhang","raw_affiliation_strings":["Hebrew SeniorLife Boston Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebrew SeniorLife Boston Massachusetts","institution_ids":["https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010336223","display_name":"Jo\u00e3o D. Fontes","orcid":"https://orcid.org/0000-0001-5011-0855","observed_orcids":["https://orcid.org/0000-0001-5011-0855"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joao D. T. Fontes","raw_affiliation_strings":["Framingham Heart Study, Framingham, and Boston University School of Medicine, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Framingham Heart Study, Framingham, and Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035126983","display_name":"James B. Meigs","orcid":"https://orcid.org/0000-0002-2439-2657","observed_orcids":["https://orcid.org/0000-0002-2439-2657"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Meigs","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059560495","display_name":"L. Adrienne Cupples","orcid":"https://orcid.org/0000-0003-0273-7965","observed_orcids":["https://orcid.org/0000-0003-0273-7965"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Adrienne Cupples","raw_affiliation_strings":["Boston University, School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University, School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011048149","display_name":"Douglas P. Kiel","orcid":"https://orcid.org/0000-0001-8474-0310","observed_orcids":["https://orcid.org/0000-0001-8474-0310"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas P. Kiel","raw_affiliation_strings":["Hebrew SeniorLife, Harvard Medical School, and Beth Israel Deaconess Medical Center; Boston Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebrew SeniorLife, Harvard Medical School, and Beth Israel Deaconess Medical Center; Boston Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071917872","display_name":"Marian T. Hannan","orcid":"https://orcid.org/0000-0002-9586-6928","observed_orcids":["https://orcid.org/0000-0002-9586-6928"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian T. Hannan","raw_affiliation_strings":["Hebrew SeniorLife, Harvard Medical School, and Beth Israel Deaconess Medical Center; Boston Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebrew SeniorLife, Harvard Medical School, and Beth Israel Deaconess Medical Center; Boston Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210123879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024388213","display_name":"Robert R. McLean","orcid":"https://orcid.org/0000-0001-5352-3794","observed_orcids":["https://orcid.org/0000-0001-5352-3794"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. McLean","raw_affiliation_strings":["Hebrew SeniorLife, Harvard Medical School, and Beth Israel Deaconess Medical Center; Boston Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebrew SeniorLife, Harvard Medical School, and Beth Israel Deaconess Medical Center; Boston Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210123879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":1.5675,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.81634398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"66","issue":"8","first_page":"1233","last_page":"1240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.8809999823570251},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.6539999842643738},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.925000011920929},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9380000233650208},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.9229999780654907},{"id":"https://openalex.org/keywords/osteoporosis-risk","display_name":"osteoporosis risk","score":0.6859999895095825},{"id":"https://openalex.org/keywords/framingham-offspring-study","display_name":"Framingham Offspring Study","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8847755789756775},{"id":"https://openalex.org/C2775854910","wikidata":"https://www.wikidata.org/wiki/Q4844892","display_name":"Femoral neck","level":3,"score":0.8132964968681335},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.7769439220428467},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6036295294761658},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5835925340652466},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5717287659645081},{"id":"https://openalex.org/C2776548296","wikidata":"https://www.wikidata.org/wiki/Q2351537","display_name":"Trochanter","level":4,"score":0.5333162546157837},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4239095449447632},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.42336955666542053},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3880256712436676}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013131","descriptor_name":"Spine","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/acr.22270","doi":"https://doi.org/10.1002/acr.22270","is_oa":false,"landing_page_url":"https://doi.org/10.1002/acr.22270","pdf_url":null,"source":{"id":"https://openalex.org/S13698240","display_name":"Arthritis Care & Research","issn_l":"0893-7524","issn":["0893-7524","1529-0123","2151-464X","2151-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Care &amp; Research","raw_type":"journal-article"},{"id":"pmid:24375982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24375982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis care & research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4069198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4069198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arthritis Care Res (Hoboken)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4069198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4069198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arthritis Care Res (Hoboken)","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1772595025","display_name":null,"funder_award_id":"R01-AR/AG041398","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G250621538","display_name":null,"funder_award_id":"N01\u2010HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4551567088","display_name":"Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study","funder_award_id":"R01AG028321","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5164707915","display_name":null,"funder_award_id":"N01-HC-025195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5312414234","display_name":"INFLAMMATION:  CORRELATES AND PROGNOSIS IN FRAMINGHAM","funder_award_id":"R01HL064753","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5572931172","display_name":"Epidemiology of Precursors to Type 2 Diabetes","funder_award_id":"K24DK080140","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5746560196","display_name":"Harvard Translational Research in Aging Training Program","funder_award_id":"T32AG023480","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6151559349","display_name":"Framingham: Inflammation, Genes & Cardiovascular Disease","funder_award_id":"R01HL076784","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880538","display_name":"Novel Molecular Biomarkers of Bone Microarchitecture","funder_award_id":"R01AR041398","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000887157","display_name":"IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL","funder_award_id":"R01HL092577","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306222","display_name":"American College of Rheumatology Research and Education Foundation","ror":"https://ror.org/05pjxvx20"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1568175712","https://openalex.org/W1948268265","https://openalex.org/W1964188104","https://openalex.org/W1976077702","https://openalex.org/W1980179699","https://openalex.org/W1981384212","https://openalex.org/W1982156095","https://openalex.org/W1986448933","https://openalex.org/W1987150557","https://openalex.org/W1989755849","https://openalex.org/W1991888400","https://openalex.org/W1996163526","https://openalex.org/W1999703499","https://openalex.org/W2002699743","https://openalex.org/W2004996094","https://openalex.org/W2010136315","https://openalex.org/W2010138979","https://openalex.org/W2011410834","https://openalex.org/W2012942026","https://openalex.org/W2013724724","https://openalex.org/W2018376606","https://openalex.org/W2032314634","https://openalex.org/W2032695379","https://openalex.org/W2040553528","https://openalex.org/W2048431634","https://openalex.org/W2055277406","https://openalex.org/W2057018521","https://openalex.org/W2066385294","https://openalex.org/W2078552483","https://openalex.org/W2079037416","https://openalex.org/W2080783947","https://openalex.org/W2082687548","https://openalex.org/W2087636919","https://openalex.org/W2095218368","https://openalex.org/W2096754770","https://openalex.org/W2099795752","https://openalex.org/W2100325831","https://openalex.org/W2109348687","https://openalex.org/W2110388554","https://openalex.org/W2110833991","https://openalex.org/W2110993073","https://openalex.org/W2114344041","https://openalex.org/W2115133477","https://openalex.org/W2117637609","https://openalex.org/W2130451642","https://openalex.org/W2142820105","https://openalex.org/W2144729682","https://openalex.org/W2147945158","https://openalex.org/W2148876140","https://openalex.org/W2160287478","https://openalex.org/W2163092745","https://openalex.org/W2164019859","https://openalex.org/W2166508623","https://openalex.org/W2170257664","https://openalex.org/W2211287272","https://openalex.org/W2316821288","https://openalex.org/W2472111703"],"related_works":["https://openalex.org/W3171980181","https://openalex.org/W2902881339","https://openalex.org/W1983075114","https://openalex.org/W3176348139","https://openalex.org/W4382795595","https://openalex.org/W1999703499","https://openalex.org/W3092977983","https://openalex.org/W4414894116","https://openalex.org/W2960413439","https://openalex.org/W2553044549"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Based":[1],"upon":[2],"evidence":[3],"in":[4,7,45,94,113,124,168,259],"animal":[5],"and":[6,23,29,51,75,77,87,131,151,182,191,194,203],"vitro":[8],"studies,":[9],"we":[10],"tested":[11],"the":[12,19,30,54,81,98,110],"hypothesis":[13],"that":[14,263],"higher":[15],"serum":[16,70,126],"concentrations":[17,71,127,266],"of":[18,49,72,97,128,257,267],"cytokines":[20],"interleukin-6":[21],"(IL-6)":[22],"tumor":[24],"necrosis":[25],"factor":[26,275],"\u03b1":[27],"(TNF\u03b1)":[28],"inflammatory":[31,268],"marker":[32],"C-reactive":[33],"protein":[34],"(CRP)":[35],"would":[36],"be":[37,272],"inversely":[38],"associated":[39,119,165,215,233],"with":[40,53,120,166,216,234],"bone":[41,117],"mineral":[42],"density":[43],"(BMD)":[44],"a":[46,121,273],"community-based":[47],"cohort":[48],"men":[50,135],"women,":[52,172],"strongest":[55],"associations":[56,179,247],"among":[57,248],"postmenopausal":[58,144,152,226,249],"women":[59,140,145,153,227,250],"not":[60,154,164,251,271],"receiving":[61,146,155,228,252],"menopause":[62],"hormonal":[63],"therapy":[64],"(MHT).":[65],"METHODS:":[66],"We":[67,103],"ascertained":[68],"fasting":[69],"IL-6,":[73,129],"TNF\u03b1,":[74,130],"CRP":[76,132,193,230],"measured":[78],"BMD":[79,114,167,184,205,218,237],"at":[80,115],"femoral":[82,195,235],"neck,":[83],"trochanter,":[84],"total":[85],"femur,":[86],"spine":[88,217],"(L2-L4)":[89],"using":[90],"dual":[91],"x-ray":[92],"absorptiometry":[93],"2,915":[95],"members":[96],"Framingham":[99],"Offspring":[100],"Study":[101],"(1996-2001).":[102],"used":[104],"multivariable":[105],"linear":[106],"regression":[107],"to":[108],"estimate":[109],"difference":[111],"(\u03b2)":[112],"each":[116],"site":[118],"1-unit":[122],"increase":[123],"log-transformed":[125],"separately":[133],"for":[134,276],"(n":[136,141,148,157],"=":[137,142,149,158,186,198,201,207,210,220,223,239,242],"1,293),":[138],"premenopausal":[139,171],"231),":[143],"MHT":[147,156],"498),":[150],"893).":[159],"RESULTS:":[160],"Inflammatory":[161],"biomarkers":[162,269],"were":[163,174,245],"men.":[169],"Among":[170],"there":[173],"statistically":[175],"significant,":[176],"modest":[177],"inverse":[178],"between":[180,192],"IL-6":[181],"trochanter":[183,204],"(\u03b2":[185,197,206,219,238],"-0.030,":[187],"P":[188,200,209,222,241],"<":[189],"0.01)":[190],"neck":[196,236],"-0.015,":[199],"0.05)":[202],"-0.014,":[208],"0.04).":[211,243],"TNF\u03b1":[212],"was":[213,231],"positively":[214,232],"0.043,":[221],"0.01).":[224],"In":[225],"MHT,":[229],"0.011,":[240],"There":[244],"no":[246],"MHT.":[253],"CONCLUSION:":[254],"The":[255],"lack":[256],"consistency":[258],"our":[260],"results":[261],"suggests":[262],"elevated":[264],"circulating":[265],"may":[270],"risk":[274],"low":[277],"BMD.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}