{"id":"https://openalex.org/W2096772012","doi":"https://doi.org/10.2337/diabetes.55.02.06.db05-1164","title":"Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice","display_name":"Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice","publication_year":2006,"publication_date":"2006-02-01","ids":{"openalex":"https://openalex.org/W2096772012","doi":"https://doi.org/10.2337/diabetes.55.02.06.db05-1164","mag":"2096772012","pmid":"https://pubmed.ncbi.nlm.nih.gov/16443782"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.55.02.06.db05-1164","doi":"https://doi.org/10.2337/diabetes.55.02.06.db05-1164","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.55.02.06.db05-1164","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003141541","display_name":"Ole-Jakob How","orcid":"https://orcid.org/0000-0003-1495-0413","observed_orcids":["https://orcid.org/0000-0003-1495-0413"]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ole-Jakob How","raw_affiliation_strings":["Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091348899","display_name":"Ellen Aasum","orcid":"https://orcid.org/0000-0002-5731-3273","observed_orcids":["https://orcid.org/0000-0002-5731-3273"]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ellen Aasum","raw_affiliation_strings":["Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111369897","display_name":"David L. Severson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David L. Severson","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W.Y. Anna Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"W.Y. Anna Chan","raw_affiliation_strings":["Hatter Institute for Cardiology Research, Faculty of Medicine, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hatter Institute for Cardiology Research, Faculty of Medicine, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040595417","display_name":"M. Faadiel Essop","orcid":"https://orcid.org/0000-0002-8434-4294","observed_orcids":["https://orcid.org/0000-0002-8434-4294"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"M. Faadiel Essop","raw_affiliation_strings":["Hatter Institute for Cardiology Research, Faculty of Medicine, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hatter Institute for Cardiology Research, Faculty of Medicine, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014232110","display_name":"Terje Steinar Larsen","orcid":"https://orcid.org/0000-0003-3314-4652","observed_orcids":["https://orcid.org/0000-0003-3314-4652"]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Terje S. Larsen","raw_affiliation_strings":["Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.9192,"has_fulltext":false,"cited_by_count":247,"citation_normalized_percentile":{"value":0.99025473,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"55","issue":"2","first_page":"466","last_page":"473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/myocardial-oxygen-consumption","display_name":"myocardial oxygen consumption","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cardiac-efficiency","display_name":"cardiac efficiency","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pressure-volume-area","display_name":"pressure-volume area","score":0.718999981880188},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7820000052452087},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/substrate-oxidation","display_name":"substrate oxidation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.984000027179718},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.7870000004768372},{"id":"https://openalex.org/keywords/myocardial-stiffness","display_name":"myocardial stiffness","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pressure-volume-relationship","display_name":"pressure-volume relationship","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7921029329299927},{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.6839827299118042},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6320909857749939},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5926854610443115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5861381888389587},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5784595608711243},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4710036814212799},{"id":"https://openalex.org/C48277249","wikidata":"https://www.wikidata.org/wiki/Q1406926","display_name":"Preload","level":3,"score":0.4667133688926697},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4586056172847748},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3661750555038452},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3209335207939148},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.31404048204421997},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.26494744420051575}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diabetes.55.02.06.db05-1164","doi":"https://doi.org/10.2337/diabetes.55.02.06.db05-1164","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.55.02.06.db05-1164","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:16443782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16443782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:bibmed.ucla.edu.ve:T070000063313/22","doi":null,"is_oa":false,"landing_page_url":"http://bibmed.ucla.edu.ve/cgi-win/be_alex.exe?Acceso=T070000063313/22&Nombrebd=bmucla","pdf_url":null,"source":{"id":"https://openalex.org/S7407064131","display_name":"UCLA - Biblioteca de Ciencias de la Salud","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I19325673","host_organization_name":"Universidad Centroccidental Lisandro Alvarado","host_organization_lineage":["https://openalex.org/I19325673"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W177640679","https://openalex.org/W1570914098","https://openalex.org/W1775749144","https://openalex.org/W1994889733","https://openalex.org/W2001913231","https://openalex.org/W2003068122","https://openalex.org/W2005197044","https://openalex.org/W2007857289","https://openalex.org/W2018510874","https://openalex.org/W2019454427","https://openalex.org/W2058536977","https://openalex.org/W2059736719","https://openalex.org/W2069689528","https://openalex.org/W2097364562","https://openalex.org/W2098612318","https://openalex.org/W2114215010","https://openalex.org/W2128140020","https://openalex.org/W2144766505","https://openalex.org/W2149657149","https://openalex.org/W2150336836","https://openalex.org/W2155351425","https://openalex.org/W2161390320","https://openalex.org/W2165425998","https://openalex.org/W2182206101","https://openalex.org/W2215667781","https://openalex.org/W2256077311","https://openalex.org/W2468296158"],"related_works":["https://openalex.org/W2169640781","https://openalex.org/W2001913231","https://openalex.org/W2103793956","https://openalex.org/W7095872250","https://openalex.org/W2101006001","https://openalex.org/W2134641588","https://openalex.org/W2293298341","https://openalex.org/W2290448798","https://openalex.org/W2523538607","https://openalex.org/W2075791946"],"abstract_inverted_index":{"Altered":[0],"cardiac":[1,15,20,98,145,186],"metabolism":[2],"and":[3,25,48,58,72,86,104,112,149],"function":[4,60],"(diabetic":[5],"cardiomyopathy)":[6],"has":[7],"been":[8],"observed":[9],"in":[10,32,91,107,110,144,153,188],"diabetes.":[11],"We":[12],"hypothesize":[13],"that":[14,134],"efficiency,":[16,99],"the":[17,119,141,159,181],"ratio":[18],"of":[19,82,118,130,175],"work":[21],"(pressure-volume":[22],"area":[23],"[PVA])":[24],"myocardial":[26,170],"oxygen":[27,193],"consumption":[28],"(MVo(2)),":[29],"is":[30],"reduced":[31],"diabetic":[33,189],"hearts.":[34],"Experiments":[35],"used":[36],"ex":[37],"vivo":[38],"working":[39],"hearts":[40,95,127,155,190],"from":[41],"control":[42],"db/+,":[43],"db/db":[44,111,126,154],"(type":[45],"2":[46],"diabetes),":[47],"db/+":[49],"mice":[50],"given":[51],"streptozotocin":[52],"(STZ;":[53],"type":[54],"1":[55],"diabetes).":[56],"PVA":[57],"ventricular":[59,167],"were":[61,89,156],"assessed":[62],"with":[63,79,161],"a":[64],"1.4-F":[65],"pressure-volume":[66,151,176],"catheter":[67],"at":[68],"low":[69],"(0.3":[70],"mmol/l)":[71,75],"high":[73],"(1.4":[74],"fatty":[76,131],"acid":[77],"concentrations":[78],"simultaneous":[80],"measurements":[81],"MVo(2).":[83],"Substrate":[84],"oxidation":[85],"mitochondrial":[87],"respiration":[88],"measured":[90],"separate":[92],"experiments.":[93],"Diabetic":[94],"showed":[96],"decreased":[97,185],"revealed":[100],"as":[101],"an":[102],"86":[103],"57%":[105],"increase":[106],"unloaded":[108],"MVo(2)":[109],"STZ-administered":[113],"hearts,":[114],"respectively.":[115],"The":[116,147],"slope":[117],"PVA-MVo(2)":[120],"regression":[121],"line":[122],"was":[123],"increased":[124],"for":[125,180,195],"after":[128],"elevation":[129],"acids,":[132],"suggesting":[133,165],"contractile":[135],"inefficiency":[136],"could":[137],"also":[138],"contribute":[139],"to":[140,158],"overall":[142],"reduction":[143],"efficiency.":[146],"end-diastolic":[148,163],"end-systolic":[150],"relationships":[152],"shifted":[157],"left":[160,166],"elevated":[162],"pressure,":[164],"remodeling":[168],"and/or":[169],"stiffness.":[171],"Thus,":[172],"by":[173,192],"means":[174],"technology,":[177],"we":[178],"have":[179],"first":[182],"time":[183],"documented":[184],"efficiency":[187],"caused":[191],"waste":[194],"noncontractile":[196],"purposes.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}