{"id":"https://openalex.org/W2096747572","doi":null,"title":"Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders.","display_name":"Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders.","publication_year":2010,"publication_date":"2010-04-03","ids":{"openalex":"https://openalex.org/W2096747572","mag":"2096747572","pmid":"https://pubmed.ncbi.nlm.nih.gov/20376328","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2848919"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2848919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2848919","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2848919","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066474989","display_name":"John H. Fingert","orcid":"https://orcid.org/0000-0002-0377-0479","observed_orcids":["https://orcid.org/0000-0002-0377-0479"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H Fingert","raw_affiliation_strings":["Department of Ophthalmology & Visual Sciences, University of Iowa, Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology & Visual Sciences, University of Iowa, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006579982","display_name":"Wallace L.M. Alward","orcid":"https://orcid.org/0000-0001-6368-9018","observed_orcids":["https://orcid.org/0000-0001-6368-9018"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wallace L Alward","raw_affiliation_strings":["University of Iowa, "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, ","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Wang","raw_affiliation_strings":["University of Iowa, "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, ","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110155612","display_name":"Thomas Yorio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Yorio","raw_affiliation_strings":["Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089627519","display_name":"Abbot F. Clark","orcid":"https://orcid.org/0000-0003-3594-6560","observed_orcids":["https://orcid.org/0000-0003-3594-6560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abbot F Clark","raw_affiliation_strings":["Graduate School of Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1463,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90796881,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"596","last_page":"601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.906000018119812},{"id":"https://openalex.org/keywords/ocular-hypertension","display_name":"ocular hypertension","score":0.847000002861023},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sr-proteins","display_name":"SR proteins","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fkbp4","display_name":"FKBP4","score":0.9610000252723694},{"id":"https://openalex.org/keywords/fkbp5","display_name":"FKBP5","score":1.0},{"id":"https://openalex.org/keywords/nr3c1","display_name":"NR3C1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/trabecular-meshwork","display_name":"trabecular meshwork","score":0.6930000185966492},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6690000295639038},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8248499631881714},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.805519700050354},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5045431852340698},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4787561297416687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4566807150840759},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.44968974590301514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4417419135570526},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4276978373527527},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.382479727268219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3625091314315796},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.291607141494751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18451079726219177}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2848919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2848919","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:20376328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20376328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:2096747572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20376328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2848919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2848919","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3123031367","display_name":"Glucocorticoids, Ocular Hypertension, and Glaucoma","funder_award_id":"R01EY016242","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1517035469","https://openalex.org/W1676993942","https://openalex.org/W1756012476","https://openalex.org/W1965038960","https://openalex.org/W1965205901","https://openalex.org/W1972726442","https://openalex.org/W1973503527","https://openalex.org/W1974791065","https://openalex.org/W1976850484","https://openalex.org/W1980991473","https://openalex.org/W1984633753","https://openalex.org/W1988506908","https://openalex.org/W1991241272","https://openalex.org/W2018412721","https://openalex.org/W2019416102","https://openalex.org/W2021045023","https://openalex.org/W2023513569","https://openalex.org/W2024843178","https://openalex.org/W2026080360","https://openalex.org/W2040481343","https://openalex.org/W2053119245","https://openalex.org/W2060764929","https://openalex.org/W2083477749","https://openalex.org/W2083621950","https://openalex.org/W2087851176","https://openalex.org/W2094610748","https://openalex.org/W2110897487","https://openalex.org/W2113784410","https://openalex.org/W2120711134","https://openalex.org/W2141969663","https://openalex.org/W2145192598","https://openalex.org/W2418506641","https://openalex.org/W2625521663"],"related_works":["https://openalex.org/W7100726150","https://openalex.org/W1802847801","https://openalex.org/W7047446353","https://openalex.org/W2028772682","https://openalex.org/W2057323820","https://openalex.org/W2060764929","https://openalex.org/W4387638483","https://openalex.org/W7101112025","https://openalex.org/W2120296632","https://openalex.org/W2282198899"],"abstract_inverted_index":{"PURPOSE:":[0],"While":[1],"chronic":[2],"glucocorticoid":[3,37],"(GC)":[4],"therapy":[5],"leads":[6],"to":[7,75,125,132,238,249],"ocular":[8,282,303],"hypertension":[9,304],"in":[10,46,67,86,141,187,219,224,241,277,293],"about":[11],"one":[12],"third":[13],"of":[14,35,58,89,120,181,280,301],"individuals,":[15],"almost":[16],"all":[17],"primary":[18],"open-angle":[19],"glaucoma":[20],"(POAG)":[21],"patients":[22],"show":[23],"this":[24,255],"response":[25],"and":[26,41,61,99,105,151,164,193,231],"are":[27,101,136,296],"called":[28],"\"steroid":[29],"responders.\"":[30],"Two":[31],"differentially":[32],"spliced":[33],"isoforms":[34],"the":[36,90,109,121,171,234,261,278,299],"receptor":[38],"(GR),":[39],"GRalpha":[40,104],"GRbeta,":[42],"regulate":[43],"GC":[44,59],"responsiveness":[45],"trabecular":[47],"meshwork":[48],"(TM)":[49],"cells.":[50],"GRbeta":[51,106],"acts":[52],"as":[53],"a":[54,200],"dominant":[55],"negative":[56],"regulator":[57],"activity":[60],"is":[62,112],"expressed":[63],"at":[64,197],"lower":[65],"levels":[66],"glaucomatous":[68],"TM":[69],"cells,":[70],"making":[71],"them":[72],"more":[73],"sensitive":[74],"GCs.":[76],"Several":[77],"arginine/serine-rich":[78],"splicing":[79,88],"factor":[80],"(SR)":[81],"proteins":[82],"have":[83,93],"been":[84],"implicated":[85],"alternative":[87],"GR.":[91],"We":[92],"previously":[94],"demonstrated":[95],"that":[96,288],"immunophilins":[97],"FKBP5":[98],"FKBP4":[100],"required":[102],"for":[103,114,184,226,266,298],"translocation":[107],"into":[108],"nucleus,":[110],"which":[111],"essential":[113],"their":[115],"biologic":[116],"activity.":[117],"The":[118],"purpose":[119],"present":[122],"study":[123],"was":[124,195,258],"use":[126],"single":[127],"nucleotide":[128],"polymorphism":[129],"(SNP)":[130],"genotyping":[131],"determine":[133],"whether":[134],"there":[135],"any":[137],"allele":[138,220],"frequency":[139],"differences":[140,218],"GR,":[142],"FKBP4/5,":[143],"or":[144,222,251,305],"SR":[145],"genes":[146,273,295],"between":[147,233],"normal":[148,160],"control,":[149],"POAG,":[150,163],"steroid":[152,166,252],"responder":[153],"populations.":[154],"METHODS:":[155],"Clinically":[156],"characterized":[157],"individuals":[158],"(400":[159],"controls,":[161],"197":[162],"107":[165],"responders)":[167],"were":[168,215,264],"recruited":[169],"from":[170],"U.":[172],"Iowa":[173],"Ophthalmology":[174],"Clinics":[175],"after":[176],"IRB":[177],"approved":[178],"consent.":[179],"Genotyping":[180],"DNA":[182],"samples":[183],"48":[185,207],"SNPs":[186,208,225,240],"SFRS3,":[188],"SFRS5,":[189,227],"SFRS9,":[190,228],"FKBP4,":[191,229],"FKBP5,":[192,230],"NR3C1":[194,232],"done":[196],"GeneSeek":[198],"using":[199],"mass":[201],"spectroscopy":[202],"based":[203],"system.":[204],"RESULTS:":[205],"All":[206],"displayed":[209],"high":[210],"call":[211],"rates":[212],"(99%).":[213],"There":[214],"no":[216],"significant":[217],"frequencies":[221],"genotypes":[223],"3":[235],"groups.":[236],"Up":[237],"three":[239],"SFRS3":[242],"had":[243],"p-values":[244],"<0.05":[245],"when":[246,260],"comparing":[247],"controls":[248],"POAG":[250],"responders,":[253],"but":[254],"statistical":[256],"significance":[257],"lost":[259],"p":[262],"values":[263],"adjusted":[265],"multiple":[267],"measures.":[268],"CONCLUSIONS:":[269],"Although":[270],"these":[271,294],"6":[272],"may":[274],"be":[275],"involved":[276],"pathogenesis":[279],"GC-induced":[281,302],"hypertension,":[283],"it":[284],"does":[285],"not":[286],"appear":[287],"major":[289],"heritable":[290],"risk":[291],"alleles":[292],"responsible":[297],"development":[300],"POAG.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
