{"id":"https://openalex.org/W2096719075","doi":"https://doi.org/10.1128/jvi.01007-10","title":"Activation of Plasmacytoid Dendritic Cells by Kaposi's Sarcoma-Associated Herpesvirus","display_name":"Activation of Plasmacytoid Dendritic Cells by Kaposi's Sarcoma-Associated Herpesvirus","publication_year":2010,"publication_date":"2010-10-28","ids":{"openalex":"https://openalex.org/W2096719075","doi":"https://doi.org/10.1128/jvi.01007-10","mag":"2096719075","pmid":"https://pubmed.ncbi.nlm.nih.gov/20980519","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3020034"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01007-10","doi":"https://doi.org/10.1128/jvi.01007-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01007-10","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3020034","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"John A. West","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. West","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091307664","display_name":"Sean M. Gregory","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean M. Gregory","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045541405","display_name":"Vijay Sivaraman","orcid":"https://orcid.org/0000-0001-9848-6640","observed_orcids":["https://orcid.org/0000-0001-9848-6640"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay Sivaraman","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091229755","display_name":"Lishan Su","orcid":"https://orcid.org/0000-0002-0350-5560","observed_orcids":["https://orcid.org/0000-0002-0350-5560"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lishan Su","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021245679","display_name":"Blossom Damania","orcid":"https://orcid.org/0000-0002-9205-1774","observed_orcids":["https://orcid.org/0000-0002-9205-1774"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Blossom Damania","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021245679"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"],"apc_list":null,"apc_paid":null,"fwci":3.2742,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.92620977,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"85","issue":"2","first_page":"895","last_page":"904"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.210099995136261,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.13109999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kaposi-s-sarcoma-associated-herpesvirus","display_name":"Kaposi's sarcoma-associated herpesvirus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8379999995231628},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tlr9-signaling","display_name":"TLR9 signaling","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.8569999933242798},{"id":"https://openalex.org/keywords/viral-infection-of-dendritic-cells","display_name":"viral infection of dendritic cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/cd83","display_name":"CD83","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9990000128746033},{"id":"https://openalex.org/keywords/viral-latency","display_name":"viral latency","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8362681865692139},{"id":"https://openalex.org/C2779594685","wikidata":"https://www.wikidata.org/wiki/Q3832899","display_name":"Primary effusion lymphoma","level":3,"score":0.82614666223526},{"id":"https://openalex.org/C2780797929","wikidata":"https://www.wikidata.org/wiki/Q983850","display_name":"Kaposi's sarcoma-associated herpesvirus","level":5,"score":0.7703728675842285},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.7024886012077332},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.6629234552383423},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.608821451663971},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6073709726333618},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5766411423683167},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5289095640182495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5288898348808289},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4922446310520172},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.4721762537956238},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.46589362621307373},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.4386858642101288},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4074844717979431},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.34403786063194275},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.22482803463935852},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.1492781937122345},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07783186435699463},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.06961479783058167},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.068179190158844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097802","descriptor_name":"CD83 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019288","descriptor_name":"Herpesvirus 8, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/jvi.01007-10","doi":"https://doi.org/10.1128/jvi.01007-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01007-10","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3020034","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3020034","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:20980519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20980519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:sq87c235f","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/axpj-ew69","pdf_url":"https://cdr.lib.unc.edu/downloads/t148fq727","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virology, 85(2)","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.885.2047","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.885.2047","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Lishan_Su/publication/47566511_Activation_of_plasmacytoid_dendritic_cells_by_Kaposi%27s_sarcoma-associated_herpesvirus/links/53fb4f7a0cf2e3cbf5662685.pdf","raw_type":"text"},{"id":"doi:10.17615/axpj-ew69","doi":"https://doi.org/10.17615/axpj-ew69","is_oa":true,"landing_page_url":"https://doi.org/10.17615/axpj-ew69","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3020034","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3020034","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1646449232","display_name":null,"funder_award_id":"F32-AI078735","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3000799958","display_name":"Treg in HIV-1 Replication and Pathogenesis","funder_award_id":"R01AI077454","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3414236437","display_name":"HIV-1 Replication and Pathogenesis in vivo","funder_award_id":"R01AI080432","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4248371752","display_name":"Innate Immunity and KSHV","funder_award_id":"R01DE018281","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4726127990","display_name":"KSHV Modulation of the Host Innate Immune System","funder_award_id":"1f32ai078735-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6938168791","display_name":"Role of KSHV Viral Proteins in Signaling and Pathogenesis","funder_award_id":"R01CA096500","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G773184794","display_name":"Science in a Culture of Mentoring","funder_award_id":"P20RR015577","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000880610","display_name":"Molecular Biology of Viral Diseases Predoctoral Training Grant","funder_award_id":"T32AI007419","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000896675","display_name":"ART Modulation of Viral Pathogenesis","funder_award_id":"R01DE018304","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096719075.pdf","grobid_xml":"https://content.openalex.org/works/W2096719075.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1514540900","https://openalex.org/W1517310071","https://openalex.org/W1534687842","https://openalex.org/W1534879090","https://openalex.org/W1579891230","https://openalex.org/W1940100272","https://openalex.org/W1981746803","https://openalex.org/W2004465286","https://openalex.org/W2007430725","https://openalex.org/W2010800481","https://openalex.org/W2020555122","https://openalex.org/W2022273444","https://openalex.org/W2022399382","https://openalex.org/W2027587005","https://openalex.org/W2032438721","https://openalex.org/W2045384882","https://openalex.org/W2046204077","https://openalex.org/W2067444184","https://openalex.org/W2069981713","https://openalex.org/W2081651119","https://openalex.org/W2093807372","https://openalex.org/W2098751820","https://openalex.org/W2104340222","https://openalex.org/W2104904748","https://openalex.org/W2118537722","https://openalex.org/W2122782505","https://openalex.org/W2137594178","https://openalex.org/W2145295873","https://openalex.org/W2148178789","https://openalex.org/W2153364522","https://openalex.org/W2157898241","https://openalex.org/W2159402147","https://openalex.org/W2159499388","https://openalex.org/W2161162286","https://openalex.org/W2161964978","https://openalex.org/W2166411505","https://openalex.org/W2167969276","https://openalex.org/W2336241188"],"related_works":["https://openalex.org/W2460526970","https://openalex.org/W2007430725","https://openalex.org/W2148178789","https://openalex.org/W2030428409","https://openalex.org/W8069308","https://openalex.org/W7099844272","https://openalex.org/W7097822974","https://openalex.org/W2162998319","https://openalex.org/W1967562647","https://openalex.org/W2010800481"],"abstract_inverted_index":{"Kaposi's":[0,11],"sarcoma-associated":[1],"herpesvirus":[2],"(KSHV)":[3],"is":[4,90,100,106,111],"associated":[5],"with":[6],"multiple":[7],"human":[8,134],"malignancies,":[9],"including":[10],"sarcoma,":[12],"primary":[13,21],"effusion":[14],"lymphoma,":[15],"and":[16,69,86,88,115,136,150,152,169,177],"multicentric":[17],"Castleman's":[18],"disease.":[19],"Following":[20],"infection,":[22,143],"KSHV":[23,110,124,131,142],"typically":[24],"goes":[25],"through":[26,91,164],"a":[27,171],"brief":[28],"period":[29],"of":[30,37,47,64,118,148,161,166,179],"lytic":[31],"replication":[32],"prior":[33],"to":[34,55,123],"the":[35,44,65,78,95,175],"establishment":[36],"latency.":[38],"Plasmacytoid":[39],"dendritic":[40],"cells":[41],"(pDCs)":[42],"are":[43,61,139],"major":[45],"producers":[46],"type":[48,96],"1":[49,97],"interferon":[50,98],"(IFN),":[51],"primarily":[52],"in":[53,102,121],"response":[54,99,122],"virus":[56],"infection.":[57,125],"Toll-like":[58],"receptors":[59,75],"(TLRs)":[60],"key":[62],"components":[63],"innate":[66],"immune":[67],"system,":[68],"they":[70],"serve":[71],"as":[72,144],"pathogen":[73],"recognition":[74],"that":[76,94,130,137,159,170],"stimulate":[77],"host":[79],"antiviral":[80],"response.":[81],"pDCs":[82,114,119,135,138],"express":[83],"exclusively":[84],"TLR7":[85],"TLR9,":[87],"it":[89,105],"these":[92],"TLRs":[93],"activated":[101,140],"pDCs.":[103,183],"Currently,":[104],"not":[107],"known":[108],"whether":[109,116],"recognized":[112],"by":[113,146,153,181],"activation":[117,165],"occurs":[120,163],"We":[126,156],"now":[127],"report":[128],"evidence":[129],"can":[132],"infect":[133],"upon":[141],"measured":[145],"upregulation":[147],"CD83":[149],"CD86":[151],"IFN-\u03b1":[154,162,180],"secretion.":[155],"further":[157],"show":[158],"induction":[160],"TLR9":[167,172],"signaling":[168],"inhibitor":[173],"diminishes":[174],"production":[176],"secretion":[178],"KSHV-infected":[182]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}