{"id":"https://openalex.org/W2096614115","doi":null,"title":"Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid.","display_name":"Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid.","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2096614115","mag":"2096614115","pmid":"https://pubmed.ncbi.nlm.nih.gov/11325828"},"language":"en","primary_location":{"id":"pmid:11325828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11325828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069704079","display_name":"Alison Whitehouse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A S Whitehouse","raw_affiliation_strings":["Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, United Kingdom","institution_ids":["https://openalex.org/I169199633"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H J Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031013910","display_name":"J L Drake","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Drake","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113615765","display_name":"Michael John Tisdale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Tisdale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3284,"has_fulltext":false,"cited_by_count":225,"citation_normalized_percentile":{"value":0.95849342,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"61","issue":"9","first_page":"3604","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.2653999924659729,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":1.0},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.9559999704360962},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.8230000138282776},{"id":"https://openalex.org/keywords/atp-dependent-proteolysis","display_name":"ATP-dependent proteolysis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8040000200271606},{"id":"https://openalex.org/keywords/myosin-expression","display_name":"myosin expression","score":0.8119999766349792},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.8159999847412109},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.9290000200271606},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.7369334101676941},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.6752572655677795},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6116114854812622},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5856693983078003},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5685479640960693},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.5388379693031311},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.509823739528656},{"id":"https://openalex.org/C197683979","wikidata":"https://www.wikidata.org/wiki/Q14876077","display_name":"Protein catabolism","level":3,"score":0.503271758556366},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.4799635410308838},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.4758034646511078},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.46080756187438965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4352642595767975},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.4229111969470978},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37147659063339233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35872089862823486},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2776409089565277},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.21819007396697998},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1696600317955017},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.149946391582489},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.11149850487709045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08473795652389526}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015118","descriptor_name":"Eicosapentaenoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:11325828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11325828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.1030","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.1030","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/61/9/3604.full.pdf","raw_type":"text"},{"id":"pmh:oai:publications.aston.ac.uk:5209","doi":null,"is_oa":false,"landing_page_url":"http://publications.aston.ac.uk/5209/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2096614115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11325828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W5484105","https://openalex.org/W72602357","https://openalex.org/W72643866","https://openalex.org/W1022317132","https://openalex.org/W1513460209","https://openalex.org/W1535606501","https://openalex.org/W1576342515","https://openalex.org/W1729354010","https://openalex.org/W1767790527","https://openalex.org/W1812339273","https://openalex.org/W1880398352","https://openalex.org/W1967950617","https://openalex.org/W1974389218","https://openalex.org/W1984111867","https://openalex.org/W1989010989","https://openalex.org/W1993049203","https://openalex.org/W1999506801","https://openalex.org/W2001481759","https://openalex.org/W2002768000","https://openalex.org/W2012587880","https://openalex.org/W2041301317","https://openalex.org/W2052121973","https://openalex.org/W2063637086","https://openalex.org/W2065918344","https://openalex.org/W2067623537","https://openalex.org/W2069229044","https://openalex.org/W2071472677","https://openalex.org/W2090188603","https://openalex.org/W2102314850","https://openalex.org/W2102589258","https://openalex.org/W2106867463","https://openalex.org/W2113617434","https://openalex.org/W2134032880","https://openalex.org/W2134488331","https://openalex.org/W2138077682","https://openalex.org/W2141377922","https://openalex.org/W2143157313","https://openalex.org/W2144567506","https://openalex.org/W2156523912","https://openalex.org/W2177302713","https://openalex.org/W2274283551"],"related_works":["https://openalex.org/W1597944380","https://openalex.org/W1998245074","https://openalex.org/W2088477747","https://openalex.org/W820170832","https://openalex.org/W2028710934","https://openalex.org/W1568022496","https://openalex.org/W2041902534","https://openalex.org/W2004830125","https://openalex.org/W1205975583","https://openalex.org/W2065918344"],"abstract_inverted_index":{"Cancer":[0],"cachexia":[1,265],"is":[2,103],"characterized":[3],"by":[4,30,121,266],"selective":[5],"depletion":[6],"of":[7,64,80,94,131,160,163,179,192,195,213,220,233,236,251,259,268,280],"skeletal":[8,260],"muscle":[9,111,130,261],"protein":[10,24,61,86],"reserves.":[11],"Soleus":[12],"muscles":[13,36,90],"from":[14,37],"mice":[15,65,132],"bearing":[16,66,133,143],"a":[17,107,225],"cachexia-inducing":[18],"tumor":[19,69,136,146,223,242,252,281],"(MAC16)":[20],"showed":[21],"an":[22,92,95,190,206],"increased":[23],"degradation":[25],"in":[26,88,110,113,128,198,208,224,241,263],"vitro,":[27],"as":[28,119,137],"measured":[29],"tyrosine":[31],"release,":[32],"when":[33],"compared":[34],"with":[35,70,149,158,205,231],"nontumor-bearing":[38],"animals.":[39],"After":[40],"incubation":[41],"under":[42],"conditions":[43],"that":[44,187,245],"modify":[45],"different":[46],"proteolytic":[47,97,101],"systems,":[48],"lysosomal,":[49],"calcium-dependent,":[50],"and":[51,83,115,167,201,228,271],"ATP-dependent":[52,96],"proteolysis":[53],"were":[54,147],"found":[55],"to":[56,58,105],"contribute":[57],"the":[59,67,71,134,144,161,168,177,180,193,221,234,237,249,276],"elevated":[60,127],"catabolism.":[62],"Treatment":[63],"MAC16":[68,135,145,222],"polyunsaturated":[72],"fatty":[73],"acid,":[74],"eicosapentaenoic":[75],"acid":[76],"(EPA),":[77],"attenuated":[78],"loss":[79,139,258],"body":[81],"weight":[82,138],"significantly":[84,126],"suppressed":[85],"catabolism":[87,112],"soleus":[89],"through":[91],"inhibition":[93,279],"pathway.":[98],"The":[99],"ATP-ubiquitin-dependent":[100],"pathway":[102],"considered":[104],"play":[106],"major":[108],"role":[109],"cachexia,":[114],"functional":[116,151],"proteasome":[117,152,165,196,239,269],"activity,":[118,124],"determined":[120],"\"chymotrypsin-like\"":[122],"enzyme":[123,182],"was":[125,154,173,203],"gastrocnemius":[129],"progressed.":[140],"When":[141],"animals":[142],"treated":[148],"EPA,":[150],"activity":[153],"completely":[155],"suppressed,":[156],"together":[157],"attenuation":[159,191],"expression":[162,178,197,235],"20S":[164,238],"alpha-subunits":[166,240],"p42":[169],"regulator,":[170],"whereas":[171],"there":[172],"no":[174],"effect":[175],"on":[176],"ubiquitin-conjugating":[181],"(E2(14k)).":[183],"These":[184],"results":[185],"suggest":[186],"EPA":[188,216,256],"induces":[189],"up-regulation":[194],"cachectic":[199],"mice,":[200],"this":[202,229,246,272],"correlated":[204,230],"increase":[207],"myosin":[209],"expression,":[210,270],"confirming":[211],"retention":[212],"contractile":[214],"proteins.":[215],"also":[217,274],"inhibited":[218],"growth":[219,253],"dose-dependent":[226],"manner,":[227],"suppression":[232],"cells,":[243],"suggesting":[244],"may":[247,273],"be":[248,275],"mechanism":[250,277],"inhibition.":[254],"Thus":[255],"antagonizes":[257],"proteins":[262],"cancer":[264],"down-regulation":[267],"for":[278],"growth.":[282]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
