{"id":"https://openalex.org/W2096593752","doi":"https://doi.org/10.1016/s0955-0674(03)00072-3","title":"Modulation of developmental signals by endocytosis: different means and many ends","display_name":"Modulation of developmental signals by endocytosis: different means and many ends","publication_year":2003,"publication_date":"2003-07-07","ids":{"openalex":"https://openalex.org/W2096593752","doi":"https://doi.org/10.1016/s0955-0674(03)00072-3","mag":"2096593752","pmid":"https://pubmed.ncbi.nlm.nih.gov/12892789"},"language":"en","primary_location":{"id":"doi:10.1016/s0955-0674(03)00072-3","doi":"https://doi.org/10.1016/s0955-0674(03)00072-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0955-0674(03)00072-3","pdf_url":null,"source":{"id":"https://openalex.org/S103771297","display_name":"Current Opinion in Cell Biology","issn_l":"0955-0674","issn":["0955-0674","1879-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058437026","display_name":"Eugenia Piddini","orcid":"https://orcid.org/0000-0003-3901-076X","observed_orcids":["https://orcid.org/0000-0003-3901-076X"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eugenia Piddini","raw_affiliation_strings":["National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047765555","display_name":"Jean\u2010Paul Vincent","orcid":"https://orcid.org/0000-0003-2305-5744","observed_orcids":["https://orcid.org/0000-0003-2305-5744"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jean-Paul Vincent","raw_affiliation_strings":["National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK","institution_ids":["https://openalex.org/I4405285715"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047765555"],"corresponding_institution_ids":["https://openalex.org/I4405285715"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.4636,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.42114094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"15","issue":"4","first_page":"474","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/developmental-signalling","display_name":"developmental signalling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/delta-ligand","display_name":"Delta ligand","score":0.6320000290870667},{"id":"https://openalex.org/keywords/patched-receptor","display_name":"Patched receptor","score":0.8410000205039978},{"id":"https://openalex.org/keywords/smoothened","display_name":"Smoothened","score":0.9229999780654907},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.6150000095367432},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta-signalling","display_name":"transforming growth factor-beta signalling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/morphogen-transport","display_name":"morphogen transport","score":0.968999981880188},{"id":"https://openalex.org/keywords/lysosome-trafficking","display_name":"lysosomal trafficking","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.9366848468780518},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.9119976758956909},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8262016177177429},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7880347967147827},{"id":"https://openalex.org/C145837895","wikidata":"https://www.wikidata.org/wiki/Q18031607","display_name":"Smoothened","level":4,"score":0.7821224927902222},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7809047698974609},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.6628414392471313},{"id":"https://openalex.org/C191597335","wikidata":"https://www.wikidata.org/wiki/Q4996475","display_name":"Bulk endocytosis","level":5,"score":0.6222898960113525},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.49137750267982483},{"id":"https://openalex.org/C2777994357","wikidata":"https://www.wikidata.org/wiki/Q24781250","display_name":"Patched","level":4,"score":0.4865323603153229},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.47202152013778687},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.4431294798851013},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3371432423591614},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3123386800289154},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.12381124496459961},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.080555260181427}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0955-0674(03)00072-3","doi":"https://doi.org/10.1016/s0955-0674(03)00072-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0955-0674(03)00072-3","pdf_url":null,"source":{"id":"https://openalex.org/S103771297","display_name":"Current Opinion in Cell Biology","issn_l":"0955-0674","issn":["0955-0674","1879-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cell Biology","raw_type":"journal-article"},{"id":"pmid:12892789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12892789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1660631781","https://openalex.org/W1873165927","https://openalex.org/W1968263279","https://openalex.org/W1972875076","https://openalex.org/W1974096298","https://openalex.org/W1974955986","https://openalex.org/W1979825058","https://openalex.org/W1982513471","https://openalex.org/W1993416164","https://openalex.org/W1993484166","https://openalex.org/W1995924696","https://openalex.org/W2000550532","https://openalex.org/W2005434843","https://openalex.org/W2007086703","https://openalex.org/W2028480293","https://openalex.org/W2028497134","https://openalex.org/W2030924655","https://openalex.org/W2033712349","https://openalex.org/W2037103320","https://openalex.org/W2042808830","https://openalex.org/W2044643509","https://openalex.org/W2046970439","https://openalex.org/W2050956563","https://openalex.org/W2051944835","https://openalex.org/W2062023115","https://openalex.org/W2065510014","https://openalex.org/W2067005574","https://openalex.org/W2067761409","https://openalex.org/W2070268999","https://openalex.org/W2075947758","https://openalex.org/W2089421579","https://openalex.org/W2093262727","https://openalex.org/W2098503611","https://openalex.org/W2108707301","https://openalex.org/W2113695281","https://openalex.org/W2116813067","https://openalex.org/W2118252860","https://openalex.org/W2122598160","https://openalex.org/W2124354752","https://openalex.org/W2128584428","https://openalex.org/W2139406254","https://openalex.org/W2144599584","https://openalex.org/W2150091300","https://openalex.org/W2153371646","https://openalex.org/W2159418321","https://openalex.org/W2161924138"],"related_works":["https://openalex.org/W2058693333","https://openalex.org/W34315733","https://openalex.org/W2080186105","https://openalex.org/W2022798729","https://openalex.org/W2028500434","https://openalex.org/W2140344684","https://openalex.org/W2094481526","https://openalex.org/W2168259679","https://openalex.org/W2045165927","https://openalex.org/W7096612434"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}