{"id":"https://openalex.org/W2096504095","doi":"https://doi.org/10.1111/j.0013-9580.2005.t01-3-64204_6.x","title":"Response: Pathogenesis of Epilepsy after Exposure to Severe Falciparum Malaria","display_name":"Response: Pathogenesis of Epilepsy after Exposure to Severe Falciparum Malaria","publication_year":2005,"publication_date":"2005-03-29","ids":{"openalex":"https://openalex.org/W2096504095","doi":"https://doi.org/10.1111/j.0013-9580.2005.t01-3-64204_6.x","mag":"2096504095"},"language":"en","primary_location":{"id":"doi:10.1111/j.0013-9580.2005.t01-3-64204_6.x","doi":"https://doi.org/10.1111/j.0013-9580.2005.t01-3-64204_6.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.0013-9580.2005.t01-3-64204_6.x","pdf_url":null,"source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035619291","display_name":"Julie A. Carter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Carter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112354901","display_name":"Brian G.R. Neville","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Neville","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014291864","display_name":"Charles R. J. C. Newton","orcid":"https://orcid.org/0000-0002-6999-5507","observed_orcids":["https://orcid.org/0000-0002-6999-5507"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Newton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":0.3708,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.72196088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"4","first_page":"601","last_page":"602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.2224999964237213,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/falciparum-malaria","display_name":"falciparum malaria","score":0.9129999876022339},{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.796999990940094},{"id":"https://openalex.org/keywords/cerebral-malaria","display_name":"cerebral malaria","score":0.8650000095367432},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.796999990940094},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5210000276565552},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.6399999856948853},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6480000019073486},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.8790380954742432},{"id":"https://openalex.org/C2908793570","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Cerebral Malaria","level":4,"score":0.8499538898468018},{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.804498016834259},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.7678818106651306},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6861047148704529},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.6724106669425964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6220228672027588},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.45600828528404236},{"id":"https://openalex.org/C2778734009","wikidata":"https://www.wikidata.org/wiki/Q55785625","display_name":"Epilepsy syndromes","level":3,"score":0.41387709975242615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4087362587451935},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3448641300201416},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.27126339077949524},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24067282676696777},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19521784782409668}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/j.0013-9580.2005.t01-3-64204_6.x","doi":"https://doi.org/10.1111/j.0013-9580.2005.t01-3-64204_6.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.0013-9580.2005.t01-3-64204_6.x","pdf_url":null,"source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:183829","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/183829/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Epilepsia , 46 (4) pp. 601-602. (2005)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1973046591","https://openalex.org/W1979051462","https://openalex.org/W2001698428","https://openalex.org/W2092945775","https://openalex.org/W2098573207","https://openalex.org/W2132764522","https://openalex.org/W2138253818","https://openalex.org/W4211134699"],"related_works":["https://openalex.org/W2006695441","https://openalex.org/W1979051462","https://openalex.org/W174020035","https://openalex.org/W1973046591","https://openalex.org/W2410329922","https://openalex.org/W7097243992","https://openalex.org/W1997970430","https://openalex.org/W2315181037","https://openalex.org/W2081002621","https://openalex.org/W1521892271"],"abstract_inverted_index":{"To":[0],"the":[1,134,146,162,168,183],"Editor:":[2],"The":[3,81,102],"causes":[4],"of":[5,9,23,39,53,67,69,74,83,136,154,165,170,182],"an":[6,29,50],"increased":[7,51],"rate":[8],"epilepsy":[10,35,54,75],"in":[11,58,76,89,115,177],"children":[12,59,78,178],"who":[13],"have":[14,112,149],"had":[15],"severe":[16,84,118],"falciparum":[17,32,40,85],"malaria":[18,33,42,44,86,119],"are":[19,105,159],"currently":[20],"a":[21,72],"matter":[22],"speculation.":[24],"Our":[25],"study":[26],"strongly":[27],"supports":[28],"association":[30],"between":[31],"and":[34,43,124,179],"(1).":[36],"Two":[37],"complications":[38],"malaria\u2014cerebral":[41],"with":[45,49,56,117,161],"complicated":[46,142,155],"seizures\u2014were":[47],"associated":[48,160],"prevalence":[52],"compared":[55],"that":[57,95],"unexposed":[60],"to":[61,152],"these":[62,77],"conditions.":[63],"Dr.":[64],"Aleem's":[65],"suggestion":[66],"granulomas":[68],"Durck":[70],"being":[71],"cause":[73],"is":[79,87],"possible.":[80],"neuropathology":[82],"discussed":[88],"several":[90,96],"studies":[91,176],"(2,3),":[92],"which":[93,158],"suggest":[94],"pathogenic":[97],"processes":[98],"could":[99],"be":[100],"involved.":[101],"most":[103],"likely":[104],"vascular/ischemic":[106],"mechanisms":[107,138,185],"(2),":[108],"because":[109],"ischemic":[110],"lesions":[111],"been":[113],"detected":[114],"adults":[116],"(4,5);":[120],"neurotoxic":[121],"effects":[122],"(6);":[123],"antibodies":[125],"against":[126],"voltage-gated":[127],"channels":[128],"(7).":[129],"We":[130],"would":[131],"also":[132],"raise":[133],"possibility":[135],"genetic":[137],"(8).":[139],"In":[140],"addition,":[141],"seizures":[143],"occurring":[144],"during":[145],"acute":[147],"episode":[148],"features":[150],"similar":[151],"those":[153],"febrile":[156],"seizures,":[157],"subsequent":[163],"development":[164],"epilepsy.":[166],"Elucidating":[167],"mechanism":[169],"epileptogenesis":[171],"will":[172],"require":[173],"magnetic":[174],"resonance":[175],"further":[180],"investigation":[181],"putative":[184],"mentioned":[186],"earlier.":[187]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2016-06-24T00:00:00"}