{"id":"https://openalex.org/W2096490409","doi":"https://doi.org/10.1016/j.juro.2012.07.037","title":"Natural History of Biochemical Recurrence After Radical Prostatectomy with Adjuvant Radiation Therapy","display_name":"Natural History of Biochemical Recurrence After Radical Prostatectomy with Adjuvant Radiation Therapy","publication_year":2012,"publication_date":"2012-09-19","ids":{"openalex":"https://openalex.org/W2096490409","doi":"https://doi.org/10.1016/j.juro.2012.07.037","mag":"2096490409","pmid":"https://pubmed.ncbi.nlm.nih.gov/22998913"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2012.07.037","doi":"https://doi.org/10.1016/j.juro.2012.07.037","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2012.07.037","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077644150","display_name":"Stephen Anthony Boorjian","orcid":"https://orcid.org/0000-0002-8705-6650","observed_orcids":["https://orcid.org/0000-0002-8705-6650"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen A. Boorjian","raw_affiliation_strings":["Department of Urology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069162638","display_name":"Matthew K. Tollefson","orcid":"https://orcid.org/0000-0002-9960-4124","observed_orcids":["https://orcid.org/0000-0002-9960-4124"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K. Tollefson","raw_affiliation_strings":["Department of Urology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110460934","display_name":"Robert Houston Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Houston Thompson","raw_affiliation_strings":["Department of Urology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009364196","display_name":"Laureano J. Rangel","orcid":"https://orcid.org/0000-0002-6012-1088","observed_orcids":["https://orcid.org/0000-0002-6012-1088"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laureano J. Rangel","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109857175","display_name":"Eric J. Bergstralh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J. Bergstralh","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067282152","display_name":"Robert Jeffrey Karnes","orcid":"https://orcid.org/0000-0003-2339-5925","observed_orcids":["https://orcid.org/0000-0003-2339-5925"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Jeffrey Karnes","raw_affiliation_strings":["Department of Urology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":3.8623,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.93766549,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"188","issue":"5","first_page":"1761","last_page":"1766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.9309999942779541},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/systemic-progression","display_name":"systemic progression","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cancer-specific-survival","display_name":"cancer-specific survival","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pathological-gleason-score","display_name":"pathological Gleason score","score":0.9330000281333923},{"id":"https://openalex.org/keywords/psa-doubling-time","display_name":"PSA doubling time","score":0.902999997138977},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/time-to-recurrence","display_name":"time to recurrence","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9635974168777466},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.8531492948532104},{"id":"https://openalex.org/C163276114","wikidata":"https://www.wikidata.org/wiki/Q484591","display_name":"Natural history","level":2,"score":0.6701043844223022},{"id":"https://openalex.org/C2777008409","wikidata":"https://www.wikidata.org/wiki/Q4914714","display_name":"Biochemical recurrence","level":5,"score":0.6362361311912537},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5421373248100281},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.5046247243881226},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.49997687339782715},{"id":"https://openalex.org/C3018454096","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant radiotherapy","level":3,"score":0.4884561598300934},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.480645090341568},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3813410699367523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3346315026283264},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.3138759732246399},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11933737993240356}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011468","descriptor_name":"Prostatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.juro.2012.07.037","doi":"https://doi.org/10.1016/j.juro.2012.07.037","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2012.07.037","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:22998913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22998913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1803311049","https://openalex.org/W1975131758","https://openalex.org/W1975323370","https://openalex.org/W1979048558","https://openalex.org/W1990294418","https://openalex.org/W2007644327","https://openalex.org/W2018998854","https://openalex.org/W2023475404","https://openalex.org/W2038981426","https://openalex.org/W2039536878","https://openalex.org/W2040659915","https://openalex.org/W2043353211","https://openalex.org/W2054739860","https://openalex.org/W2061332484","https://openalex.org/W2066558203","https://openalex.org/W2071879495","https://openalex.org/W2077219580","https://openalex.org/W2078098429","https://openalex.org/W2101889062","https://openalex.org/W2103003357","https://openalex.org/W2104870101","https://openalex.org/W2109199549","https://openalex.org/W2120859422","https://openalex.org/W2140754632","https://openalex.org/W2142391938","https://openalex.org/W2144312415","https://openalex.org/W2151114651","https://openalex.org/W2152715017","https://openalex.org/W2154974136","https://openalex.org/W2156306108","https://openalex.org/W2156776019","https://openalex.org/W3023689102","https://openalex.org/W4239319701","https://openalex.org/W4249663626","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2109199549","https://openalex.org/W2317630542","https://openalex.org/W2154647137","https://openalex.org/W2004521947","https://openalex.org/W3023689102","https://openalex.org/W7097011938","https://openalex.org/W1588432179","https://openalex.org/W1175312092","https://openalex.org/W2238979065","https://openalex.org/W2127168222"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1,30],"evaluated":[2],"the":[3,59,191,238,256],"long-term":[4],"outcome":[5],"of":[6,21,98,114,193,200,216,240,260],"patients":[7,83,137,235],"with":[8,14,34,74,85,190,212],"biochemical":[9,35,54,78,86,117,140,201],"recurrence":[10,36,55,87,124,141,202],"following":[11,37],"radical":[12,38,149,204],"prostatectomy":[13,39,122,150,205],"adjuvant":[15,41,207],"radiation":[16,42,208],"therapy":[17,43,209],"and":[18,91,104,143,152,171,222,248,258],"determined":[19],"predictors":[20],"systemic":[22,75,89,102,194,220],"progression":[23,76,90,221],"in":[24,233],"these":[25,217],"men.":[26],"MATERIALS":[27],"AND":[28],"METHODS:":[29],"identified":[31],"134":[32],"men":[33,218],"plus":[40,206],"for":[44,136],"pT(any)N0M0":[45],"disease.":[46],"Median":[47,101,119],"followup":[48,115],"was":[49,56,125,132],"13.1":[50],"years.":[51,127],"Survival":[52],"after":[53,77,116,148,203],"estimated":[57],"using":[58],"Kaplan-Meier":[60],"method.":[61],"Cox":[62],"proportional":[63],"hazard":[64],"regression":[65],"models":[66],"were":[67,108,187],"used":[68],"to":[69,123,229],"analyze":[70],"clinicopathological":[71],"variables":[72],"associated":[73,189],"recurrence.":[79,118],"RESULTS:":[80],"Overall,":[81],"41":[82],"(31.5%)":[84],"experienced":[88,139],"57":[92],"(42.5%)":[93],"died,":[94],"including":[95],"19":[96],"(14.2%)":[97],"prostate":[99,173,225,250],"cancer.":[100,226],"progression-free":[103],"cancer":[105,129],"specific":[106,130,174,251],"survival":[107,131],"not":[109,133],"attained":[110],"at":[111],"15":[112],"years":[113,147],"time":[120,177,182],"from":[121,224],"3.3":[126,146],"Ten-year":[128],"significantly":[134,188],"different":[135],"who":[138],"less":[142],"greater":[144],"than":[145,179],"(83%":[151],"83%,":[153],"respectively,":[154],"p":[155,168,185],"=":[156,169],"0.39).":[157],"Moreover,":[158],"on":[159,244],"multivariate":[160],"analysis":[161],"increased":[162],"pathological":[163,245],"Gleason":[164,246],"score":[165,247],"(HR":[166],"1.78,":[167],"0.02)":[170],"rapid":[172],"antigen":[175,252],"doubling":[176,181,253],"(less":[178],"6-month":[180],"HR":[183],"11.39,":[184],"<0.0001)":[186],"risk":[192,239],"progression.":[195],"CONCLUSIONS:":[196],"The":[197,227],"natural":[198],"history":[199],"is":[210],"heterogeneous":[211],"only":[213],"a":[214],"minority":[215],"experiencing":[219],"death":[223],"decision":[228],"begin":[230],"additional":[231],"therapies":[232],"such":[234],"must":[236],"balance":[237],"disease":[241],"progression,":[242],"based":[243],"postoperative":[249],"time,":[254],"against":[255],"cost":[257],"morbidity":[259],"treatment.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
