{"id":"https://openalex.org/W2096480779","doi":null,"title":"Micro-SPET/CT and histology results of zoledronate treatment in a nude mouse lung adenocarcinoma skeletal metastases model: a pilot study.","display_name":"Micro-SPET/CT and histology results of zoledronate treatment in a nude mouse lung adenocarcinoma skeletal metastases model: a pilot study.","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2096480779","mag":"2096480779","pmid":"https://pubmed.ncbi.nlm.nih.gov/24520579"},"language":"en","primary_location":{"id":"pmid:24520579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24520579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hellenic journal of nuclear medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102942130","display_name":"Yiqiu Zhang","orcid":"https://orcid.org/0009-0006-3917-6005","observed_orcids":["https://orcid.org/0009-0006-3917-6005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiqiu Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035915328","display_name":"Dengfeng Cheng","orcid":"https://orcid.org/0000-0003-2886-3273","observed_orcids":["https://orcid.org/0000-0003-2886-3273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dengfeng Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112076489","display_name":"Hongcheng Shi","orcid":"https://orcid.org/0000-0001-7457-876X","observed_orcids":["https://orcid.org/0000-0001-7457-876X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongcheng Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034190584","display_name":"Hui Min Tan","orcid":"https://orcid.org/0000-0002-4833-7337","observed_orcids":["https://orcid.org/0000-0002-4833-7337"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083678838","display_name":"Bing Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102257509","display_name":"Yushen Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yushen Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000778989","display_name":"Beilei Li","orcid":"https://orcid.org/0000-0002-0932-5851","observed_orcids":["https://orcid.org/0000-0002-0932-5851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beilei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"3","first_page":"240","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spc-a-1-cells","display_name":"SPC-A1 cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/nude-mouse-model","display_name":"nude mouse model","score":0.7419999837875366},{"id":"https://openalex.org/keywords/histological-evaluation","display_name":"histological evaluation","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9322740435600281},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.7097294330596924},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6309343576431274},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.5694231390953064},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4953140318393707},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4684807062149048},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.45601513981819153},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.45491671562194824},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.40517979860305786},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3767397999763489},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3713567852973938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17526507377624512}],"mesh":[{"descriptor_ui":"D000077211","descriptor_name":"Zoledronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24520579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24520579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hellenic journal of nuclear medicine","raw_type":"Journal Article"},{"id":"mag:2096480779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24520579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W174268426","https://openalex.org/W1984900038","https://openalex.org/W2009437563","https://openalex.org/W2034663338","https://openalex.org/W2125698716","https://openalex.org/W2128778774","https://openalex.org/W2139705209","https://openalex.org/W2172011512"],"related_works":["https://openalex.org/W2373735662","https://openalex.org/W3041224157","https://openalex.org/W2013571231","https://openalex.org/W2033782429","https://openalex.org/W6338572","https://openalex.org/W2090532747","https://openalex.org/W2122748411","https://openalex.org/W2265072771","https://openalex.org/W7017508191","https://openalex.org/W2021505980"],"abstract_inverted_index":{"Some":[0],"studies":[1],"have":[2,31],"evaluated":[3],"the":[4,10,41,72,134],"efficacy":[5],"of":[6,12,43,76,101,115,137],"bisphospho":[7],"nates":[8],"for":[9,124],"prevention":[11],"bone":[13,35,91],"metastases":[14,36,59],"in":[15,24,37,133],"breast,":[16],"prostate,":[17],"and":[18,40,117],"lung":[19,38,56,65],"cancers,":[20],"as":[21,23],"well":[22],"multiple":[25],"myeloma":[26],"[1],":[27],"but":[28],"whether":[29],"bisphosphonates":[30],"anti-tumor":[32],"activity":[33],"against":[34],"cancer,":[39],"mechanism":[42],"this":[44,53,122],"possible":[45],"effect,":[46],"remain":[47],"to":[48,89,94,148],"be":[49],"elucidated":[50],"[2].":[51],"In":[52],"study,":[54],"a":[55],"cancer":[57],"skeletal":[58],"model":[60],"was":[61,87,110],"established":[62],"by":[63],"injecting":[64],"adenocarcinoma":[66,128],"cell":[67,129],"line":[68,130],"SPC-A-1":[69,131],"cells":[70,132],"into":[71],"left":[73],"proximal":[74],"tibias":[75],"4":[77],"nude":[78],"mice.":[79],"Microscopic":[80],"SPET":[81],"(microSPET)/spiral":[82],"computed":[83],"tomography":[84],"(CT)":[85],"imaging":[86,109],"used":[88],"characterize":[90],"tumors":[92],"prior":[93],"initiating":[95],"treatment":[96],"with":[97],"daily":[98],"subcutaneous":[99],"injections":[100],"either":[102],"zoledronate":[103],"or":[104],"saline":[105],"control.":[106],"Repeat":[107],"micro-SPET/CT":[108],"obtained":[111],"after":[112],"12":[113],"days":[114],"treatment,":[116],"animals":[118],"were":[119,139,146],"sacrificed":[120],"at":[121],"time":[123],"histologic":[125],"analysis.":[126],"Lung":[127],"exponential":[135],"phase":[136],"growth":[138],"cultured":[140],"using":[141],"serum-free":[142],"media.":[143],"Cell":[144],"concentrations":[145],"adjusted":[147],"10":[149],"7":[150]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
