{"id":"https://openalex.org/W2096458951","doi":"https://doi.org/10.1046/j.1529-8027.2001.01007-23.x","title":"\u03b1\u03b21 Integrins Are Required For Normal Peripheral Nerve Development","display_name":"\u03b1\u03b21 Integrins Are Required For Normal Peripheral Nerve Development","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2096458951","doi":"https://doi.org/10.1046/j.1529-8027.2001.01007-23.x","mag":"2096458951"},"language":"en","primary_location":{"id":"doi:10.1046/j.1529-8027.2001.01007-23.x","doi":"https://doi.org/10.1046/j.1529-8027.2001.01007-23.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1529-8027.2001.01007-23.x","pdf_url":null,"source":{"id":"https://openalex.org/S91695523","display_name":"Journal of the Peripheral Nervous System","issn_l":"1085-9489","issn":["1085-9489","1529-8027"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Peripheral Nervous System","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104350740","display_name":"ML Feltri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"ML Feltri","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024143813","display_name":"Angelo Quattrini","orcid":"https://orcid.org/0000-0002-8226-8320","observed_orcids":["https://orcid.org/0000-0002-8226-8320"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A Quattrini","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011852209","display_name":"Stefano Carlo Previtali","orcid":"https://orcid.org/0000-0003-2546-4357","observed_orcids":["https://orcid.org/0000-0003-2546-4357"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"S Previtali","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012200131","display_name":"Alessandro Nodari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A Nodari","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039153202","display_name":"Barbara Migliavacca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"B Migliavacca","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079659004","display_name":"Diana Graus-Porta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"D Graus\u2010Porta","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085446151","display_name":"Amanda J. Littlewood-Evans","orcid":"https://orcid.org/0000-0001-7760-6535","observed_orcids":["https://orcid.org/0000-0001-7760-6535"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A Littlewood\u2010Evans","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080356197","display_name":"Albee Messing","orcid":"https://orcid.org/0000-0001-6049-0521","observed_orcids":["https://orcid.org/0000-0001-6049-0521"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A Messing","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101732294","display_name":"Ulrich W. Mueller","orcid":"https://orcid.org/0000-0003-2736-6494","observed_orcids":["https://orcid.org/0000-0003-2736-6494"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"U Mueller","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057822205","display_name":"Lawrence G. Wrabetz","orcid":"https://orcid.org/0000-0003-3360-1032","observed_orcids":["https://orcid.org/0000-0003-3360-1032"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"L. Wrabetz","raw_affiliation_strings":["FMI, Basel, Switzerland","San Raffaele Scientific Institute, Milano, Italy","University of Wisconsin-Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMI, Basel, Switzerland","institution_ids":[]},{"raw_affiliation_string":"San Raffaele Scientific Institute, Milano, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"University of Wisconsin-Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17280937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"1","first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.28999999165534973,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.28999999165534973,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.20200000703334808,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.1273999959230423,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/peripheral-nervous-system-development","display_name":"peripheral nervous system development","score":0.8849999904632568},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.9760000109672546},{"id":"https://openalex.org/keywords/congenital-muscular-dystrophy","display_name":"congenital muscular dystrophy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/laminin-alpha2-chain","display_name":"laminin alpha2 chain","score":0.7419999837875366},{"id":"https://openalex.org/keywords/axon-sorting","display_name":"axon sorting","score":0.6320000290870667},{"id":"https://openalex.org/keywords/dystroglycan","display_name":"dystroglycan","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cre-loxp-conditional-knockout","display_name":"Cre-loxP conditional knockout","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.671881914138794},{"id":"https://openalex.org/C2777004073","wikidata":"https://www.wikidata.org/wiki/Q465621","display_name":"Schwann cell","level":2,"score":0.6494898200035095},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.6008833646774292},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5535611510276794},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.5279247760772705},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5202630758285522},{"id":"https://openalex.org/C2778384963","wikidata":"https://www.wikidata.org/wiki/Q5319588","display_name":"Dystroglycan","level":4,"score":0.5113791823387146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4729984402656555},{"id":"https://openalex.org/C2779333224","wikidata":"https://www.wikidata.org/wiki/Q809756","display_name":"Basal lamina","level":3,"score":0.4452612102031708},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.41153115034103394},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37477171421051025},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3443793058395386},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3375943601131439},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17975106835365295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1760329008102417},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16434034705162048},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1302087903022766},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.10612651705741882},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1046/j.1529-8027.2001.01007-23.x","doi":"https://doi.org/10.1046/j.1529-8027.2001.01007-23.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1529-8027.2001.01007-23.x","pdf_url":null,"source":{"id":"https://openalex.org/S91695523","display_name":"Journal of the Peripheral Nervous System","issn_l":"1085-9489","issn":["1085-9489","1529-8027"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Peripheral Nervous System","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116758711","https://openalex.org/W2128436211","https://openalex.org/W7098141542","https://openalex.org/W2135983283","https://openalex.org/W2130618942","https://openalex.org/W1974987292","https://openalex.org/W2061151520","https://openalex.org/W2157419186","https://openalex.org/W2062352406","https://openalex.org/W2157355817"],"abstract_inverted_index":{"Adhesion":[0],"to":[1,10,73,123,229,235,243,291],"basal":[2],"lamina":[3],"is":[4,52,65,108],"required":[5],"for":[6,57,135,275,282],"Schwann":[7,215,277],"cells":[8,216],"(SC)":[9],"form":[11],"normal":[12,276],"myelin":[13],"in":[14,24,46,61,67,117,120,126,138,150,169,171,199,210,226,241,258,308],"peripheral":[15,32,81,207,311],"nerves.":[16,312],"In":[17,79,248],"human":[18],"Congenital":[19],"Muscular":[20],"Dystrophy":[21],"(CMD),":[22],"mutations":[23],"laminin":[25,48,100],"2":[26],"(\u03b12":[27],"chain)":[28],"cause":[29],"a":[30,44,133,136,184,204],"dysmyelinating":[31,206],"neuropathy":[33],"with":[34,173,181],"slow":[35],"nerve":[36,68,212,250],"conduction":[37],"velocities.":[38],"The":[39,59,286],"dy2J/dy2J":[40,63,294],"mouse":[41,64,295],"also":[42],"carries":[43],"mutation":[45],"the":[47,62,98,145,161,218,255,259,303],"\u03b12":[49],"chain,":[50],"and":[51,90,141,223,245,264],"considered":[53],"an":[54],"animal":[55],"model":[56],"CMD.":[58],"dysmyelination":[60],"dramatic":[66],"roots,":[69],"where":[70],"SC":[71,99,151,170,252],"fail":[72],"sort":[74,244],"bundles":[75,237],"of":[76,92,97,113,167,190,220,238,261,288,293,302,305],"naked":[77,239],"axons.":[78],"distal":[80],"nerves,":[82,222,231],"myelination":[83,283],"can":[84,253],"proceed,":[85],"even":[86,257],"if":[87],"axon/SC":[88,139],"interactions":[89],"nodes":[91],"Ranvier":[93],"are":[94,224,233,273],"abnormal.":[95],"Which":[96],"receptors,":[101],"integrins":[102,272,299],"or":[103],"dystroglycan":[104],"mediate":[105,300],"these":[106],"functions":[107],"unclear":[109],"because":[110],"targeted":[111],"inactivation":[112],"those":[114],"genes":[115,168],"results":[116],"embryonic":[118,211],"death":[119],"mice":[121,156,180,182,194,202],"prior":[122],"myelination.":[124,142],"Several":[125],"vitro":[127],"studies":[128],"suggest":[129],"\u03b21":[130,146,196,262],"integrin":[131,147,197],"as":[132],"candidate":[134],"role":[137],"interaction":[140],"To":[143],"inactivate":[144],"gene":[148],"(mIntb1)":[149],"only,":[152],"we":[153,192],"produced":[154,193],"transgenic":[155],"expressing":[157],"Cre":[158],"recombinase":[159],"using":[160],"vector":[162],"mP0TOT,":[163],"that":[164,270,292,297],"activates":[165],"expression":[166],"parallel":[172],"P0":[174],"during":[175],"development.":[176,213],"By":[177],"crossing":[178],"mP0TOT(Cre)":[179],"carrying":[183],"mIntb1":[185],"flanked":[186],"by":[187],"loxP":[188],"sites":[189],"recombination,":[191],"lacking":[195],"specifically":[198],"SC.":[200],"These":[201,267],"have":[203],"severe":[205],"neuropathy,":[208],"originating":[209],"Although":[214],"populate":[217],"length":[219],"forming":[221],"present":[225],"numbers":[227],"comparable":[228],"wildtype":[230],"they":[232],"unable":[234],"penetrate":[236],"axons":[240],"order":[242],"ensheath":[246],"them.":[247],"some":[249,301],"fascicles,":[251],"bypass":[254],"block,":[256],"absence":[260],"integrin,":[263],"myelinate":[265],"normally.":[266],"data":[268],"show":[269],"\u03b1\u03b21":[271,298],"necessary":[274],"cell\u2010axon":[278],"interactions,":[279],"but":[280],"not":[281],"per":[284],"se.":[285],"similarity":[287],"this":[289],"phenotype":[290],"suggests":[296],"effects":[304],"altered":[306],"laminin\u20102":[307],"impaired":[309],"CMD":[310]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}