{"id":"https://openalex.org/W2096458557","doi":null,"title":"Pharmacokinetics and pharmacodynamics of prednisolone after intravenous and oral administration.","display_name":"Pharmacokinetics and pharmacodynamics of prednisolone after intravenous and oral administration.","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W2096458557","mag":"2096458557","pmid":"https://pubmed.ncbi.nlm.nih.gov/1428295"},"language":"en","primary_location":{"id":"pmid:1428295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1428295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology, therapy, and toxicology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033732811","display_name":"J\u00fcrgen Barth","orcid":"https://orcid.org/0000-0001-7096-7178","observed_orcids":["https://orcid.org/0000-0001-7096-7178"]},"institutions":[{"id":"https://openalex.org/I4210139845","display_name":"BG University Hospital Bergmannsheil Bochum","ror":"https://ror.org/04j9bvy88","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210139845"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Barth","raw_affiliation_strings":["Universit\u00e4tsklinik Bergmannsheil, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinik Bergmannsheil, Bochum, Germany","institution_ids":["https://openalex.org/I4210139845"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Damoiseaux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Damoiseaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078485413","display_name":"H M\u00f6llmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H M\u00f6llmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028864036","display_name":"Kerry Brandis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K H Brandis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033045204","display_name":"G\u00fcnther Hochhaus","orcid":"https://orcid.org/0000-0002-7406-5558","observed_orcids":["https://orcid.org/0000-0002-7406-5558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Hochhaus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078634243","display_name":"Hartmut Derendorf","orcid":"https://orcid.org/0000-0003-4016-1370","observed_orcids":["https://orcid.org/0000-0003-4016-1370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Derendorf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5292,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.64720263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"9","first_page":"317","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":1.0},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.7799999713897705},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.996999979019165},{"id":"https://openalex.org/keywords/time-dependent-pharmacokinetics","display_name":"time-dependent pharmacokinetics","score":0.7580000162124634},{"id":"https://openalex.org/keywords/circadian-variation","display_name":"circadian variation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.7519999742507935},{"id":"https://openalex.org/keywords/blood-cell-count","display_name":"blood cell count","score":0.8130000233650208},{"id":"https://openalex.org/keywords/corticosteroid-effects","display_name":"corticosteroid effects","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.9596965909004211},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8734791874885559},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.7684249877929688},{"id":"https://openalex.org/C2776476923","wikidata":"https://www.wikidata.org/wiki/Q7725","display_name":"Evening","level":2,"score":0.6588600277900696},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6511722803115845},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6347944736480713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5791867971420288},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.502255916595459},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4777618944644928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3312481939792633},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1428295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1428295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology, therapy, and toxicology","raw_type":"Journal Article"},{"id":"mag:2096458557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1428295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107392494","https://openalex.org/W1989107666","https://openalex.org/W2031051228","https://openalex.org/W1965319246","https://openalex.org/W2148770868","https://openalex.org/W1600397741","https://openalex.org/W52176933","https://openalex.org/W2377489426","https://openalex.org/W2922892982","https://openalex.org/W2304344236"],"abstract_inverted_index":{"The":[0,44,96,141],"pharmacokinetics":[1,101,127,161,227],"and":[2,16,31,61,76,107,117,132,202],"pharmacodynamics":[3,56],"of":[4,13,38,47,57,102,128,143,162,167,187,194,228,237],"prednisolone":[5,19,26,34,39,48,103,129,163],"were":[6,49,78,209],"investigated":[7],"according":[8],"to":[9,224,233],"four":[10,213],"different":[11,214],"routes":[12],"administration:":[14],"20":[15,24,115,144],"40":[17,32,118],"mg":[18,25,33,116,119,145],"orally":[20,27],"in":[21,28,36,41,111,147,155,177,181],"the":[22,29,42,55,82,84,87,93,100,126,148,151,156,160,172,178,182,185,188,192,212,225,238],"morning,":[23],"evening":[30,157],"intravenously":[35],"form":[37],"phosphate":[40],"morning.":[43],"plasma":[45,112],"levels":[46,60],"followed":[50],"using":[51],"HPLC.":[52],"To":[53,80],"study":[54,190],"prednisolone,":[58,229],"glucose":[59],"various":[62],"blood":[63,199,203],"cell":[64,200],"parameters":[65],"such":[66],"as":[67],"erythrocytes,":[68],"leukocytes,":[69],"segmented":[70],"neutrophilic":[71],"granulocytes,":[72],"eosinophils,":[73],"basophils,":[74],"monocytes":[75],"lymphocytes":[77],"followed.":[79],"summarize":[81],"data,":[83],"area":[85],"under":[86],"effect-time-curve":[88],"(AUCE)":[89],"was":[90],"calculated":[91],"by":[92],"trapezoidal":[94],"rule.":[95],"results":[97,186],"show":[98],"that":[99,125,159,222],"is":[104,231],"dose-dependent":[105,133],"(non-linear)":[106],"time-dependent.":[108],"Prednisolone":[109],"concentrations":[110,176],"after":[113,164],"a":[114,135],"dose":[120,153],"are":[121,130],"very":[122],"similar,":[123],"indicating":[124],"non-linear":[131],"with":[134,150,174],"higher":[136,139,175],"clearance":[137],"for":[138,211],"concentrations.":[140],"comparison":[142],"administered":[146],"morning":[149,179],"same":[152],"given":[154],"shows":[158],"oral":[165],"administration":[166],"equal":[168],"doses":[169],"changes":[170],"during":[171],"day":[173],"than":[180],"evening.":[183],"Furthermore,":[184],"present":[189],"confirm":[191],"presence":[193],"pharmacodynamic":[195],"corticosteroid":[196],"effects":[197],"on":[198],"count":[201],"glucose.":[204],"No":[205],"statistically":[206],"significant":[207],"differences":[208],"observed":[210],"treatments.":[215],"In":[216],"summary,":[217],"it":[218,230],"can":[219],"be":[220],"concluded":[221],"due":[223],"complex":[226],"difficult":[232],"make":[234],"accurate":[235],"predictions":[236],"expected":[239],"effect-time":[240],"relationships.":[241]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
