{"id":"https://openalex.org/W2096280508","doi":null,"title":"Pharmacokinetic profile of bisphosphonates in the treatment of metabolic bone disorders.","display_name":"Pharmacokinetic profile of bisphosphonates in the treatment of metabolic bone disorders.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2096280508","mag":"2096280508","pmid":"https://pubmed.ncbi.nlm.nih.gov/22460750","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2781185"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2781185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2781185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Cases Miner Bone Metab","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2781185","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040882061","display_name":"LUIGI SINIGAGLIA","orcid":"https://orcid.org/0000-0002-5502-630X","observed_orcids":["https://orcid.org/0000-0002-5502-630X"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Sinigaglia","raw_affiliation_strings":["Chair and Department of Rheumatology Gaetano Pini Institute University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair and Department of Rheumatology Gaetano Pini Institute University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000845595","display_name":"MASSIMO VARENNA","orcid":"https://orcid.org/0000-0002-8644-0909","observed_orcids":["https://orcid.org/0000-0002-8644-0909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Varenna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082324320","display_name":"Silvia Casari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia Casari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1787,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.61376832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"4","issue":"1","first_page":"30","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.05420000106096268,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9919999837875366},{"id":"https://openalex.org/keywords/metabolic-bone-disease","display_name":"metabolic bone disease","score":0.8740000128746033},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.8169999718666077},{"id":"https://openalex.org/keywords/farnesyl-pyrophosphate-synthase","display_name":"farnesyl diphosphate synthase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hydroxyapatite-binding","display_name":"hydroxyapatite binding","score":0.8970000147819519},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8259999752044678},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nitrogen-containing-bisphosphonates","display_name":"nitrogen-containing bisphosphonates","score":0.8159999847412109},{"id":"https://openalex.org/keywords/dosing-interval","display_name":"dosing interval","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.7834500074386597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.721892774105072},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6684194207191467},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6423667669296265},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6383631229400635},{"id":"https://openalex.org/C2776990775","wikidata":"https://www.wikidata.org/wiki/Q2699676","display_name":"Farnesyl pyrophosphate","level":4,"score":0.5551517009735107},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5297946333885193},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5161982178688049},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45349064469337463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3858267664909363},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2781735062599182},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2533508539199829},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1718815565109253},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.17009779810905457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1310223937034607},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2781185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2781185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Cases Miner Bone Metab","raw_type":"Text"},{"id":"pmid:22460750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22460750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.bice.rm.cnr.it:4803","doi":null,"is_oa":true,"landing_page_url":"http://eprints.bice.rm.cnr.it/4803/1/portiere.php.pdf","pdf_url":"http://eprints.bice.rm.cnr.it/4803/1/portiere.php.pdf","source":{"id":"https://openalex.org/S4306402016","display_name":"CNR Solar (Scientific Open-access Literature Archive and Repository) (Consiglio Nazionale delle Ricerche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155236","host_organization_name":"National Research Council","host_organization_lineage":["https://openalex.org/I4210155236"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:2096280508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22460750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2781185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2781185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Cases Miner Bone Metab","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096280508.pdf","grobid_xml":"https://content.openalex.org/works/W2096280508.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W56539144","https://openalex.org/W83222219","https://openalex.org/W107357288","https://openalex.org/W1595083713","https://openalex.org/W1897499866","https://openalex.org/W1965065271","https://openalex.org/W1965511198","https://openalex.org/W1966722256","https://openalex.org/W1967461726","https://openalex.org/W1968557485","https://openalex.org/W1970155252","https://openalex.org/W1970623841","https://openalex.org/W1971712306","https://openalex.org/W1973947102","https://openalex.org/W1974903174","https://openalex.org/W1975107690","https://openalex.org/W1975805439","https://openalex.org/W1976991071","https://openalex.org/W1978228601","https://openalex.org/W1979193732","https://openalex.org/W1989637027","https://openalex.org/W1994414479","https://openalex.org/W1995181451","https://openalex.org/W1997073483","https://openalex.org/W2001013535","https://openalex.org/W2002074462","https://openalex.org/W2004135633","https://openalex.org/W2006951696","https://openalex.org/W2008985536","https://openalex.org/W2009678900","https://openalex.org/W2012181214","https://openalex.org/W2014634439","https://openalex.org/W2017654113","https://openalex.org/W2019731805","https://openalex.org/W2019964791","https://openalex.org/W2021563247","https://openalex.org/W2024098071","https://openalex.org/W2024887507","https://openalex.org/W2027248329","https://openalex.org/W2030472387","https://openalex.org/W2030989965","https://openalex.org/W2031851347","https://openalex.org/W2033586513","https://openalex.org/W2035373485","https://openalex.org/W2037935981","https://openalex.org/W2038321403","https://openalex.org/W2039223695","https://openalex.org/W2039669790","https://openalex.org/W2040874414","https://openalex.org/W2043494467","https://openalex.org/W2049405916","https://openalex.org/W2053201692","https://openalex.org/W2054616090","https://openalex.org/W2057332307","https://openalex.org/W2058788578","https://openalex.org/W2059180322","https://openalex.org/W2061235833","https://openalex.org/W2063068824","https://openalex.org/W2072268794","https://openalex.org/W2072797307","https://openalex.org/W2075774801","https://openalex.org/W2075929809","https://openalex.org/W2076107807","https://openalex.org/W2076769374","https://openalex.org/W2081588688","https://openalex.org/W2081887629","https://openalex.org/W2090642025","https://openalex.org/W2093164779","https://openalex.org/W2099054178","https://openalex.org/W2102050391","https://openalex.org/W2104298626","https://openalex.org/W2106142458","https://openalex.org/W2115809051","https://openalex.org/W2116751183","https://openalex.org/W2118190246","https://openalex.org/W2124646087","https://openalex.org/W2128778774","https://openalex.org/W2136023404","https://openalex.org/W2145741990","https://openalex.org/W2152063648","https://openalex.org/W2153265866","https://openalex.org/W2160032820","https://openalex.org/W2161962336","https://openalex.org/W2162067646","https://openalex.org/W2164933519","https://openalex.org/W2167260952","https://openalex.org/W2168222534","https://openalex.org/W2340568734","https://openalex.org/W2341257405","https://openalex.org/W2408306201","https://openalex.org/W2412267698","https://openalex.org/W2600169644","https://openalex.org/W4242400697"],"related_works":["https://openalex.org/W7005148712","https://openalex.org/W2006825597","https://openalex.org/W2172170054","https://openalex.org/W2045929587","https://openalex.org/W2134304734","https://openalex.org/W1965795911","https://openalex.org/W7073917805","https://openalex.org/W2103545729","https://openalex.org/W2029620076","https://openalex.org/W2127493057"],"abstract_inverted_index":{"The":[0],"pharmacokinetic":[1],"profile":[2],"of":[3,29,48,64,80,82,119,145],"bisphosphonates":[4,36,71,100],"is":[5,73],"complex":[6],"and":[7,20,89,114,129,138,147,151,166],"depends":[8],"on":[9,21,43,98,112,124],"their":[10,17,90,106,140],"potency":[11,79,92],"in":[12,67,77,93,102,143],"inhibiting":[13],"bone":[14,33,136,163],"resorption":[15],"through":[16,109],"cellular":[18,41],"effects":[19,97,111],"the":[22,27,46,49,62],"physicochemical":[23],"action":[24,142],"related":[25],"to":[26,121,176],"interaction":[28],"these":[30,96,133],"compounds":[31,55],"with":[32,158,172],"matrix.":[34],"Amino-substituted":[35],"exert":[37,56,139],"a":[38,57,74,83],"more":[39],"potent":[40],"effect":[42,59],"osteoclast":[44],"via":[45],"inhibition":[47,81],"mevalonate":[50],"pathway,":[51],"whereas":[52],"non-nitrogen":[53],"containing":[54],"weaker":[58],"deriving":[60],"from":[61],"induction":[63],"intracellular":[65],"metabolites":[66],"osteoclasts.":[68],"For":[69],"nitrogen-containing":[70],"there":[72],"correlation":[75],"between":[76],"vitro":[78],"specific":[84],"enzyme,":[85],"farnesyl":[86],"pyrophosphate":[87],"synthase,":[88],"antiresorptive":[91],"vivo.":[94],"Besides":[95],"osteoclasts,":[99],"may":[101,130],"part":[103],"mediate":[104],"indirectly":[105],"antiresoprtive":[107],"activity":[108],"several":[110],"osteoblasts":[113],"osteocytes.":[115],"Different":[116],"binding":[117,164],"affinities":[118],"bisphopshonates":[120],"hydroxyapatite":[122],"depend":[123],"both":[125],"side":[126],"chains":[127],"structures":[128],"explain":[131],"how":[132],"drugs":[134],"reach":[135],"cells":[137],"prolonged":[141],"terms":[144],"adsorption":[146],"desorption":[148],"processes.":[149],"Clinical":[150],"animal-models":[152],"derived":[153],"data":[154],"indicate":[155],"that":[156],"agents":[157],"high":[159],"anti-resorptive":[160],"potency,":[161],"favourable":[162],"characteristics":[165],"good":[167],"tolerability":[168],"can":[169],"be":[170],"used":[171],"long":[173],"between-dose":[174],"intervals":[175],"optimize":[177],"therapeutic":[178],"outcomes.":[179]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
