{"id":"https://openalex.org/W2096246799","doi":"https://doi.org/10.1161/01.atv.16.3.455","title":"Factor VII Hyperactivity and Endothelial Cell Damage Are Found in Elderly Hypertensives Only When Concomitant With Microalbuminuria","display_name":"Factor VII Hyperactivity and Endothelial Cell Damage Are Found in Elderly Hypertensives Only When Concomitant With Microalbuminuria","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2096246799","doi":"https://doi.org/10.1161/01.atv.16.3.455","mag":"2096246799","pmid":"https://pubmed.ncbi.nlm.nih.gov/8630673"},"language":"en","primary_location":{"id":"doi:10.1161/01.atv.16.3.455","doi":"https://doi.org/10.1161/01.atv.16.3.455","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.16.3.455","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017863780","display_name":"Kazuomi Kario","orcid":"https://orcid.org/0000-0002-8251-4480","observed_orcids":["https://orcid.org/0000-0002-8251-4480"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuomi Kario","raw_affiliation_strings":["From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","Kazuomi Kario From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210097704"]},{"raw_affiliation_string":"Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Kazuomi Kario From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","institution_ids":[]},{"raw_affiliation_string":"the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110050446","display_name":"Takefumi Matsuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takefumi Matsuo","raw_affiliation_strings":["From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","Takefumi Matsuo From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210097704"]},{"raw_affiliation_string":"Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Takefumi Matsuo From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","institution_ids":[]},{"raw_affiliation_string":"the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103538412","display_name":"Hiroko Kobayashi","orcid":"https://orcid.org/0000-0002-1660-0575","observed_orcids":["https://orcid.org/0000-0002-1660-0575"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Kobayashi","raw_affiliation_strings":["From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","Hiroko Kobayashi From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210097704"]},{"raw_affiliation_string":"Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Hiroko Kobayashi From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","institution_ids":[]},{"raw_affiliation_string":"the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000871279","display_name":"Miyako Matsuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miyako Matsuo","raw_affiliation_strings":["From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","Miyako Matsuo From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210097704"]},{"raw_affiliation_string":"Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Miyako Matsuo From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","institution_ids":[]},{"raw_affiliation_string":"the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027218703","display_name":"Toshiyuki Sakata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Sakata","raw_affiliation_strings":["From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","Toshiyuki Sakata From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210097704"]},{"raw_affiliation_string":"Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Toshiyuki Sakata From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","institution_ids":[]},{"raw_affiliation_string":"the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015658424","display_name":"Toshiyuki Miyata","orcid":"https://orcid.org/0000-0001-7088-142X","observed_orcids":["https://orcid.org/0000-0001-7088-142X"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Miyata","raw_affiliation_strings":["From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","Toshiyuki Miyata From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210097704"]},{"raw_affiliation_string":"Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Toshiyuki Miyata From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","institution_ids":[]},{"raw_affiliation_string":"the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103137983","display_name":"Kazuyuki Shimada","orcid":"https://orcid.org/0000-0002-5383-2666","observed_orcids":["https://orcid.org/0000-0002-5383-2666"]},"institutions":[{"id":"https://openalex.org/I146500386","display_name":"Jichi Medical University","ror":"https://ror.org/010hz0g26","country_code":"JP","type":"education","lineage":["https://openalex.org/I146500386"]},{"id":"https://openalex.org/I4210097704","display_name":"Hyogo Prefectural Awaji Medical Center","ror":"https://ror.org/00w1fsg08","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210097704"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyuki Shimada","raw_affiliation_strings":["From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","Kazuyuki Shimada From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo; the Department of Internal Medicine (K.K., T. Matsuo) and Central Laboratory (H.K., M.M.), Hyogo Prefectural Awaji Hospital, Sumoto; Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka; and the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386","https://openalex.org/I4210097704"]},{"raw_affiliation_string":"Clinical Laboratory (T.S.) and Research Institute (T. Miyata), National Cardiovascular Center, Suita, Osaka","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Kazuyuki Shimada From the Department of Internal Medicine (K.K.), Awaji-Hokudan Public Clinic, Hokudan, Hyogo","institution_ids":[]},{"raw_affiliation_string":"the Department of Cardiology (K.S.), Jichi Medical School, Tochigi, Japan","institution_ids":["https://openalex.org/I146500386"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8678,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.84579535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"3","first_page":"455","last_page":"461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.18960000574588776,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.8790000081062317},{"id":"https://openalex.org/keywords/microalbuminuria","display_name":"microalbuminuria","score":0.9459999799728394},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8169999718666077},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8339999914169312},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6069999933242798},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":1.0},{"id":"https://openalex.org/keywords/white-coat-hypertension","display_name":"white coat hypertension","score":0.8650000095367432},{"id":"https://openalex.org/keywords/sustained-hypertension","display_name":"sustained hypertension","score":0.9559999704360962},{"id":"https://openalex.org/keywords/coagulation-activation","display_name":"coagulation activation","score":0.5720000267028809},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.6320000290870667},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure-monitoring","display_name":"ambulatory blood pressure monitoring","score":0.7089999914169312},{"id":"https://openalex.org/keywords/urinary-albumin-excretion-rate","display_name":"urinary albumin excretion rate","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2781203188","wikidata":"https://www.wikidata.org/wiki/Q1676817","display_name":"Microalbuminuria","level":3,"score":0.8878023624420166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7366158366203308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6670176386833191},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.6511659622192383},{"id":"https://openalex.org/C201267052","wikidata":"https://www.wikidata.org/wiki/Q414446","display_name":"Thrombomodulin","level":4,"score":0.5995446443557739},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.5781583786010742},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5371385812759399},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.513787567615509},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.44448941946029663},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4152843654155731},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.17185384035110474},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.07348287105560303}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000419","descriptor_name":"Albuminuria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005167","descriptor_name":"Factor VII","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018180","descriptor_name":"Thrombomodulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.atv.16.3.455","doi":"https://doi.org/10.1161/01.atv.16.3.455","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.atv.16.3.455","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},{"id":"pmid:8630673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8630673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, thrombosis, and vascular biology","raw_type":"Journal Article"},{"id":"mag:2887348009","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/atvb.16.3.455?cited-by=yesl16%2F3%2F455","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Arteriosclerosis Thrombosis and Vascular Biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W110290653","https://openalex.org/W117253928","https://openalex.org/W128594463","https://openalex.org/W167520159","https://openalex.org/W1503653645","https://openalex.org/W1519050139","https://openalex.org/W1562310675","https://openalex.org/W1983595521","https://openalex.org/W2002125546","https://openalex.org/W2008994051","https://openalex.org/W2011277038","https://openalex.org/W2013230314","https://openalex.org/W2025866227","https://openalex.org/W2037742336","https://openalex.org/W2043951336","https://openalex.org/W2046809996","https://openalex.org/W2049860020","https://openalex.org/W2057233709","https://openalex.org/W2062429189","https://openalex.org/W2066001927","https://openalex.org/W2079116408","https://openalex.org/W2082141756","https://openalex.org/W2084124265","https://openalex.org/W2098646235","https://openalex.org/W2102199589","https://openalex.org/W2103382606","https://openalex.org/W2109788829","https://openalex.org/W2116627666","https://openalex.org/W2118461623","https://openalex.org/W2122934303","https://openalex.org/W2123159073","https://openalex.org/W2246663507","https://openalex.org/W2255950219","https://openalex.org/W2396823375","https://openalex.org/W2407067283","https://openalex.org/W2418876388","https://openalex.org/W2469365318","https://openalex.org/W3144919213","https://openalex.org/W4233069367"],"related_works":["https://openalex.org/W2381247470","https://openalex.org/W2061786432","https://openalex.org/W2050203735","https://openalex.org/W2103382606","https://openalex.org/W2384748540","https://openalex.org/W2321845163","https://openalex.org/W3163945188","https://openalex.org/W2382923968","https://openalex.org/W2370565359","https://openalex.org/W2098646235"],"abstract_inverted_index":{"We":[0,71],"studied":[1],"the":[2,99,111,121,126,140,144,163,185,221,233,286],"relationship":[3],"among":[4,241],"albuminuria,":[5],"factor":[6,34],"VII":[7],"(FVII)":[8],"hyperactivity,":[9],"and":[10,36,44,48,83,92,104,115,201,253,262,277],"endothelial":[11,45,254,280],"cell":[12,46,255,281],"damage":[13,282],"in":[14,78,220,232,292],"6":[15],"elderly":[16,242],"hypertensive":[17,81,123,223],"subjects.":[18],"The":[19],"plasma":[20],"levels":[21,100,219,273],"of":[22,101,146,168,170,187,217,250,274,279,289],"activated":[23],"FVII":[24,26,29,42,171,251,275],"(FVIIa),":[25],"coagulant":[27],"activity,":[28],"antigen":[30],"(FVIIag),":[31],"von":[32],"Willebrand":[33],"(vWF),":[35],"thrombomodulin":[37,202],"were":[38,107],"measured":[39],"to":[40,61,131,154,159,173,177,182,191,197,205,210],"assess":[41],"hyperactivity":[43],"damage,":[47,256],"urinary":[49],"albumin":[50],"excretion":[51],"rate":[52],"(UAE)":[53],"was":[54],"calculated":[55],"using":[56],"12-hour":[57],"nighttime":[58],"(7":[59],"pm":[60],"7":[62],"am)":[63],"urine":[64],"collection":[65],"(mean":[66,148],"for":[67,143,285],"2":[68],"consecutive":[69],"nights).":[70],"performed":[72],"24-hour":[73],"ambulatory":[74],"blood":[75],"pressure":[76],"monitoring":[77],"all":[79],"61":[80],"patients":[82,258],"classified":[84],"them":[85],"into":[86],"a":[87,93],"white-coat":[88,112,260],"hypertension":[89,95,113,261,294],"group":[90,96,114,142,224],"(n=12)":[91],"sustained":[94,122],"(n=49).":[97],"For":[98],"FVII,":[102],"vWF,":[103],"thrombomodulin,":[105],"there":[106],"no":[108],"differences":[109],"between":[110],"normotensive":[116,141,234],"control":[117,235],"subjects":[118],"(n=25).":[119],"In":[120,214],"group,":[124],"only":[125,244],"microalbuminuric":[127],"subgroup":[128],"(UAE,":[129],"15":[130],"300":[132],"microgram/min:":[133],"n=30)":[134],"showed":[135],"significant":[136],"elevation":[137],"compared":[138],"with":[139,246,259,295],"level":[145,186],"FVIIa":[147],"[95%":[149],"confidence":[150],"interval]:":[151],"4.0":[152],"[3.6":[153],"4.4]":[155],"versus":[156,179,194,207],"3.0":[157],"[2.6":[158],"3.3]":[160],"ng/mL,":[161,212],"P<.001),":[162],"FVIIa/FVIIag":[164],"ratio":[165],"(an":[166],"indicator":[167],"activation":[169,252],"zymogen":[172],"FVIIa)":[174],"(1.33":[175],"[1.19":[176],"1.50]":[178],"1.04":[180],"[0.92":[181],"1.19],":[183],"P<.01),":[184,200],"vWF":[188],"(188":[189],"[165":[190],"214]":[192],"%":[193],"144":[195],"[129":[196],"160]":[198],"%,":[199],"(11.7":[203],"[10.3":[204],"13.3]":[206],"9.3":[208],"[8.5":[209],"10.3]":[211],"P<.01).":[213],"contrast,":[215],"none":[216],"these":[218,268],"normoalbuminuric":[222,263],"(UAE":[225],"<15":[226],"microgram/min,":[227],"n=19)":[228],"differed":[229],"from":[230],"that":[231,240],"group.":[236],"These":[237],"results":[238],"suggest":[239],"hypertensives,":[243],"those":[245],"microalbuminuria":[247],"show":[248,267],"enhancement":[249],"while":[257],"hypertensives":[264],"do":[265],"not":[266],"accompanying":[269],"abnormalities.":[270],"Thus,":[271],"increased":[272],"activity":[276],"markers":[278],"might":[283],"account":[284],"higher":[287],"risk":[288],"cardiovascular":[290],"events":[291],"essential":[293],"microalbuminuria.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
