{"id":"https://openalex.org/W2096230282","doi":"https://doi.org/10.1186/1742-2094-8-167","title":"Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF","display_name":"Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF","publication_year":2011,"publication_date":"2011-11-30","ids":{"openalex":"https://openalex.org/W2096230282","doi":"https://doi.org/10.1186/1742-2094-8-167","mag":"2096230282","pmid":"https://pubmed.ncbi.nlm.nih.gov/22129063","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260201"},"language":"en","primary_location":{"id":"doi:10.1186/1742-2094-8-167","doi":"https://doi.org/10.1186/1742-2094-8-167","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-8-167","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-167","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-167","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026473199","display_name":"Shinya Dohgu","orcid":"https://orcid.org/0000-0002-8036-0510","observed_orcids":["https://orcid.org/0000-0002-8036-0510"]},"institutions":[{"id":"https://openalex.org/I31784960","display_name":"Fukuoka University","ror":"https://ror.org/04nt8b154","country_code":"JP","type":"education","lineage":["https://openalex.org/I31784960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Dohgu","raw_affiliation_strings":["Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan","institution_ids":["https://openalex.org/I31784960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089152362","display_name":"Melissa A. Fleegal","orcid":"https://orcid.org/0000-0002-7515-1060","observed_orcids":["https://orcid.org/0000-0002-7515-1060"]},"institutions":[{"id":"https://openalex.org/I128677303","display_name":"Clarke University","ror":"https://ror.org/03byx8t68","country_code":"US","type":"education","lineage":["https://openalex.org/I128677303"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A Fleegal-DeMotta","raw_affiliation_strings":["Biology Department, Clarke University, Dubuque, IA, USA","Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA","Geriatric Research Educational, and Clinical Center-St. Louis, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Clarke University, Dubuque, IA, USA","institution_ids":["https://openalex.org/I128677303"]},{"raw_affiliation_string":"Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Geriatric Research Educational, and Clinical Center-St. Louis, St. Louis, MO, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054959155","display_name":"William A. Banks","orcid":"https://orcid.org/0000-0002-0496-3619","observed_orcids":["https://orcid.org/0000-0002-0496-3619"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William A Banks","raw_affiliation_strings":["Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA","Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, University of Washington, Seattle, WA, USA","Geriatric Research Educational, and Clinical Center-St. Louis, St. Louis, MO, USA","Geriatric Research Educational, and Clinical Center-Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Geriatric Research Educational, and Clinical Center-St. Louis, St. Louis, MO, USA","institution_ids":[]},{"raw_affiliation_string":"Geriatric Research Educational, and Clinical Center-Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210094549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054959155"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210094549","https://openalex.org/I47838141"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":2.4713,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.87173397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"167","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transcellular-transport","display_name":"transcellular transport","score":0.7689999938011169},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9539999961853027},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.953000009059906},{"id":"https://openalex.org/keywords/p44-42-mapk","display_name":"p44/42 MAPK","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7139999866485596},{"id":"https://openalex.org/keywords/transendothelial-electrical-resistance","display_name":"transendothelial electrical resistance","score":0.7099999785423279},{"id":"https://openalex.org/keywords/paracellular-permeability","display_name":"paracellular permeability","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C176285220","wikidata":"https://www.wikidata.org/wiki/Q7833830","display_name":"Transcellular","level":2,"score":0.8417453765869141},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.8311018347740173},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.6419856548309326},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5919809937477112},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.578911304473877},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5688052773475647},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5669822692871094},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5046528577804565},{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.46778640151023865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.452892005443573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4310510754585266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37069135904312134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3504941165447235},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.33549922704696655},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.30405259132385254},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2667553722858429},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.2262953817844391},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.12963086366653442},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09459924697875977},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057167","descriptor_name":"Claudins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057900","descriptor_name":"Transcytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D062507","descriptor_name":"Claudin-5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062793","descriptor_name":"Occludin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1742-2094-8-167","doi":"https://doi.org/10.1186/1742-2094-8-167","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-8-167","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-167","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2267310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260201","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3260201","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260201","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neuroinflammation","raw_type":"Text"},{"id":"pmid:22129063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22129063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroinflammation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fcfa1be3f8b64b9c959506a28e14fd12","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fcfa1be3f8b64b9c959506a28e14fd12","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroinflammation, Vol 8, Iss 1, p 167 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1742-2094-8-167","doi":"https://doi.org/10.1186/1742-2094-8-167","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-8-167","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-167","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1356092923","display_name":null,"funder_award_id":"N01CO12400","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G174812244","display_name":"DCTD Computer Support","funder_award_id":"n01co12400-79-0-22","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1775848016","display_name":"Prion Transport Across the Blood-Brain Barrier","funder_award_id":"R01NS050547","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3218122094","display_name":"Oxidative Dysfunction of LRP at the Blood-brain Barrier in Alzheimer's Disease","funder_award_id":"R01AG029839","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3277247684","display_name":null,"funder_award_id":"N01-CO-12400","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320321793","display_name":"Beijing Municipal Education Commission","ror":"https://ror.org/04bpn6s66"},{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096230282.pdf","grobid_xml":"https://content.openalex.org/works/W2096230282.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W136462","https://openalex.org/W198813657","https://openalex.org/W249118332","https://openalex.org/W1613383360","https://openalex.org/W1902114397","https://openalex.org/W1961642276","https://openalex.org/W1965396662","https://openalex.org/W1967081185","https://openalex.org/W1969773497","https://openalex.org/W1970730429","https://openalex.org/W1973010584","https://openalex.org/W1982730947","https://openalex.org/W1987206979","https://openalex.org/W2000980663","https://openalex.org/W2002885540","https://openalex.org/W2009905886","https://openalex.org/W2014712282","https://openalex.org/W2023834531","https://openalex.org/W2024442062","https://openalex.org/W2033259268","https://openalex.org/W2040854989","https://openalex.org/W2043482309","https://openalex.org/W2043747048","https://openalex.org/W2045074773","https://openalex.org/W2046468113","https://openalex.org/W2062470194","https://openalex.org/W2063452612","https://openalex.org/W2066517837","https://openalex.org/W2077193261","https://openalex.org/W2080467344","https://openalex.org/W2083034526","https://openalex.org/W2086840459","https://openalex.org/W2087423729","https://openalex.org/W2090737417","https://openalex.org/W2092380790","https://openalex.org/W2092793916","https://openalex.org/W2095963083","https://openalex.org/W2097074610","https://openalex.org/W2098804965","https://openalex.org/W2099850307","https://openalex.org/W2103097492","https://openalex.org/W2105301861","https://openalex.org/W2120653113","https://openalex.org/W2122483069","https://openalex.org/W2122496291","https://openalex.org/W2142102457","https://openalex.org/W2152322676","https://openalex.org/W2154322652","https://openalex.org/W2158969445","https://openalex.org/W2165697317","https://openalex.org/W2166046051","https://openalex.org/W2232289451","https://openalex.org/W2304131176","https://openalex.org/W2341962341","https://openalex.org/W2414975677","https://openalex.org/W2494310079","https://openalex.org/W4320578718"],"related_works":["https://openalex.org/W2092380790","https://openalex.org/W2147555925","https://openalex.org/W7096504547","https://openalex.org/W2043747048","https://openalex.org/W2097477483","https://openalex.org/W3111006786","https://openalex.org/W7046099684","https://openalex.org/W2030496942","https://openalex.org/W1995440985","https://openalex.org/W2103097492"],"abstract_inverted_index":{"Elevated":[0],"levels":[1],"of":[2,8,27,34,44,80,138,156,169,177,180],"cytokines/chemokines":[3],"contribute":[4],"to":[5,98,172],"increased":[6,67,121],"neuroinvasion":[7],"human":[9],"immunodeficiency":[10],"virus":[11],"type":[12],"1":[13],"(HIV-1).":[14],"Previous":[15],"work":[16],"showed":[17],"that":[18,60,145],"lipopolysaccharide":[19],"(LPS),":[20],"which":[21],"is":[22],"present":[23],"in":[24,51,162],"the":[25,37,42,135,153,166,170,174],"plasma":[26],"patients":[28],"with":[29,91,95],"HIV-1,":[30],"enhanced":[31],"transcellular":[32,175],"transport":[33,82,176],"HIV-1":[35,81,122,178],"across":[36],"blood-brain":[38],"barrier":[39],"(BBB)":[40],"through":[41],"activation":[43],"p38":[45,148],"mitogen-activated":[46],"protein":[47],"kinase":[48,126],"(MAPK)":[49],"signaling":[50,150],"brain":[52],"microvascular":[53],"endothelial":[54],"cells":[55],"(BMECs).":[56],"Here,":[57],"we":[58],"found":[59],"LPS":[61,86],"(100":[62],"\u03bcg/mL,":[63],"4":[64],"hr)":[65],"selectively":[66],"interleukin":[68],"(IL)-6":[69],"and":[70,100,129,140,147,158],"granulocyte-macrophage":[71],"colony-stimulating":[72],"factor":[73],"(GM-CSF)":[74],"release":[75,137,155],"from":[76],"BMECs.":[77],"The":[78],"enhancement":[79],"induced":[83],"by":[84,89,108],"luminal":[85,167],"was":[87],"neutralized":[88],"treatment":[90],"luminal,":[92],"but":[93,114],"not":[94,115],"abluminal,":[96,116],"antibodies":[97],"IL-6":[99,117,139,157],"GM-CSF":[101,119],"without":[102],"affecting":[103],"paracellular":[104,183],"permeability":[105],"as":[106],"measured":[107],"transendothelial":[109],"electrical":[110],"resistance":[111],"(TEER).":[112],"Luminal,":[113],"or":[118],"also":[120],"transport.":[123],"U0126":[124],"(MAPK":[125],"(MEK)1/2":[127],"inhibitor)":[128,133],"SB203580":[130],"(p38":[131],"MAPK":[132,149],"decreased":[134],"LPS-enhanced":[136,154],"GM-CSF.":[141,159],"These":[142,160],"results":[143],"show":[144],"p44/42":[146],"pathways":[151],"mediate":[152],"cytokines,":[161],"turn,":[163],"act":[164],"at":[165],"surface":[168],"BMEC":[171],"enhance":[173],"independently":[179],"actions":[181],"on":[182],"permeability.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}