{"id":"https://openalex.org/W2096215586","doi":null,"title":"Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.","display_name":"Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2096215586","mag":"2096215586","pmid":"https://pubmed.ncbi.nlm.nih.gov/7834618"},"language":"en","primary_location":{"id":"pmid:7834618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7834618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045419282","display_name":"Geoffrey Ira Shapiro","orcid":"https://orcid.org/0000-0002-3331-4095","observed_orcids":["https://orcid.org/0000-0002-3331-4095"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G I Shapiro","raw_affiliation_strings":["Department of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044113012","display_name":"Christian D. Edwards","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C D Edwards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052878737","display_name":"Lester Kobzik","orcid":"https://orcid.org/0000-0003-4328-937X","observed_orcids":["https://orcid.org/0000-0003-4328-937X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Kobzik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005646248","display_name":"John J. Godleski","orcid":"https://orcid.org/0000-0001-5550-6656","observed_orcids":["https://orcid.org/0000-0001-5550-6656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Godleski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036450155","display_name":"William G. Richards","orcid":"https://orcid.org/0000-0003-0990-8317","observed_orcids":["https://orcid.org/0000-0003-0990-8317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Richards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109939587","display_name":"David J. Sugarbaker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Sugarbaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060446154","display_name":"Barrett J. Rollins","orcid":"https://orcid.org/0000-0003-4450-7092","observed_orcids":["https://orcid.org/0000-0003-4450-7092"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B J Rollins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":18.9439,"has_fulltext":false,"cited_by_count":340,"citation_normalized_percentile":{"value":0.99531581,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"55","issue":"3","first_page":"505","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9769999980926514},{"id":"https://openalex.org/keywords/rb-inactivation","display_name":"Rb inactivation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/p16ink4","display_name":"p16INK4","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lung-cancer-cell-lines","display_name":"lung cancer cell lines","score":0.8100000023841858},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.7899136543273926},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.7453797459602356},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.7415544986724854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6989436149597168},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5173632502555847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5136958360671997},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4968576729297638},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4843348264694214},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.45646870136260986},{"id":"https://openalex.org/C2909444961","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small Cell Lung Carcinoma","level":4,"score":0.43967968225479126},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43232131004333496},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.42209097743034363},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39695316553115845},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.29836758971214294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27767878770828247},{"id":"https://openalex.org/C2779292878","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small-cell carcinoma","level":3,"score":0.13911503553390503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08888828754425049},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08878299593925476}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016161","descriptor_name":"Genes, Retinoblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7834618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7834618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.2764","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.2764","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/55/3/505.full.pdf","raw_type":"text"},{"id":"mag:2096215586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7834618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4433811956","display_name":"CLINICAL/EXPERIMENTAL PHARMACOLOGY OF RESPIRATORY CANCER","funder_award_id":"P01CA019589","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7901935614","display_name":"CANCER AND LEUKEMIA GROUP B","funder_award_id":"U10CA059594","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W81266651","https://openalex.org/W1501631032","https://openalex.org/W1983348452","https://openalex.org/W1994082723","https://openalex.org/W1997073961","https://openalex.org/W2012293213","https://openalex.org/W2046577405","https://openalex.org/W2066848701","https://openalex.org/W2085588237","https://openalex.org/W2117308812","https://openalex.org/W2136166173","https://openalex.org/W2137084288","https://openalex.org/W2156157871","https://openalex.org/W2157866949","https://openalex.org/W2171367003"],"related_works":["https://openalex.org/W2070207712","https://openalex.org/W1601604261","https://openalex.org/W143753117","https://openalex.org/W1996339349","https://openalex.org/W2382195322","https://openalex.org/W2161846667","https://openalex.org/W2045518196","https://openalex.org/W323845688","https://openalex.org/W2094284771","https://openalex.org/W2368081467"],"abstract_inverted_index":{"cdk4-mediated":[0],"phosphorylation":[1],"of":[2,74,92,100,111,119],"the":[3,126],"retinoblastoma":[4],"susceptibility":[5],"protein":[6],"(Rb)":[7],"is":[8,34,45],"stimulated":[9],"by":[10,17],"cyclin":[11,58,62],"D1,":[12],"an":[13,86],"oncogene,":[14],"and":[15,38,50,54,65,90,115,132,140,151],"inhibited":[16],"p16,":[18,84],"a":[19,136,146],"candidate":[20],"tumor":[21],"suppressor.":[22],"We":[23],"examined":[24],"these":[25],"proteins":[26],"in":[27,70,109,117,135],"non-small":[28],"cell":[29,40,55,78,95],"lung":[30,41],"cancer":[31,42],"(NSCLC),":[32],"which":[33,44],"predominantly":[35],"Rb":[36,46,66,130],"positive,":[37],"small":[39],"(SCLC),":[43],"negative.":[47],"Most":[48],"NSCLC":[49,77,88,113,150],"SCLC":[51,94,121],"resection":[52,104],"specimens":[53],"lines":[56,79,96],"overexpress":[57],"D1":[59,63],"(indicating":[60],"that":[61],"overexpression":[64],"inactivation":[67,131],"can":[68],"coexist":[69],"SCLC).":[71],"However,":[72],"9":[73,75],"Rb-positive":[76],"have":[80,97],"absent":[81],"or":[82],"low":[83],"while":[85],"Rb-negative":[87],"line":[89],"5":[91,93,120],"high":[98],"levels":[99],"p16.":[101],"In":[102],"primary":[103],"specimens,":[105],"p16":[106,133,143],"was":[107],"undetectable":[108],"18":[110],"27":[112],"samples":[114],"abundant":[116],"4":[118],"samples.":[122],"Our":[123],"data":[124],"confirm":[125],"predicted":[127],"reciprocity":[128],"between":[129,149],"expression":[134,144],"common":[137],"human":[138],"malignancy":[139],"define":[141],"differential":[142],"as":[145],"fundamental":[147],"distinction":[148],"SCLC.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
