{"id":"https://openalex.org/W2096199583","doi":"https://doi.org/10.4049/jimmunol.1202659","title":"TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment","display_name":"TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment","publication_year":2012,"publication_date":"2012-12-31","ids":{"openalex":"https://openalex.org/W2096199583","doi":"https://doi.org/10.4049/jimmunol.1202659","mag":"2096199583","pmid":"https://pubmed.ncbi.nlm.nih.gov/23277487","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3552130"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1202659","doi":"https://doi.org/10.4049/jimmunol.1202659","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1202659","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3552130","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100721796","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-2628-4027","observed_orcids":["https://orcid.org/0000-0002-2628-4027","https://orcid.org/0009-0002-8669-0016","https://orcid.org/0009-0007-7563-8673"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Basic Science Program, Science Applications International Corporation\u2013Frederick, National Cancer Institute\u2013Frederick , Frederick, MD 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Program, Science Applications International Corporation\u2013Frederick, National Cancer Institute\u2013Frederick , Frederick, MD 21702","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I880747138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101255095","display_name":"Xueqiang Wu","orcid":"https://orcid.org/0000-0003-0519-5962","observed_orcids":["https://orcid.org/0000-0003-0519-5962"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueqiang Wu","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick , Frederick, MD 21702","\u2020Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD 21702; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick , Frederick, MD 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"\u2020Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD 21702; and","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038446150","display_name":"Qiong Zhou","orcid":"https://orcid.org/0000-0002-3120-3017","observed_orcids":["https://orcid.org/0000-0002-3120-3017"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiong Zhou","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick , Frederick, MD 21702","\u2020Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD 21702; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick , Frederick, MD 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"\u2020Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD 21702; and","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067466991","display_name":"O. M. Zack Howard","orcid":"https://orcid.org/0000-0002-0505-7052","observed_orcids":["https://orcid.org/0000-0002-0505-7052"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O M Zack Howard","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick , Frederick, MD 21702","\u2020Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD 21702; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick , Frederick, MD 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"\u2020Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD 21702; and","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027955775","display_name":"Mihai Gheorghe Netea","orcid":"https://orcid.org/0000-0003-2421-6052","observed_orcids":["https://orcid.org/0000-0003-2421-6052"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mihai G Netea","raw_affiliation_strings":["Department of Medicine, Radboud University Nijmegen Medical Center , 6500 HB Nijmegen,","\u2021Department of Medicine, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Radboud University Nijmegen Medical Center , 6500 HB Nijmegen,","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]},{"raw_affiliation_string":"\u2021Department of Medicine, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042240287","display_name":"Joost J. Oppenheim","orcid":"https://orcid.org/0000-0003-0271-7921","observed_orcids":["https://orcid.org/0000-0003-0271-7921"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joost J Oppenheim","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick , Frederick, MD 21702","\u2020Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD 21702; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick , Frederick, MD 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"\u2020Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute\u2013Frederick, Frederick, MD 21702; and","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100721796"],"corresponding_institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I880747138"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":6.126,"has_fulltext":false,"cited_by_count":296,"citation_normalized_percentile":{"value":0.97172602,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"190","issue":"3","first_page":"1076","last_page":"1084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnfr2","display_name":"TNFR2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/foxp3-expression","display_name":"Foxp3 expression","score":0.8349999785423279},{"id":"https://openalex.org/keywords/treg-stability","display_name":"Treg stability","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tnf-receptor-signaling","display_name":"TNF receptor signaling","score":0.5649999976158142},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.6489999890327454},{"id":"https://openalex.org/keywords/inflammatory-environment","display_name":"inflammatory environment","score":0.7509999871253967},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/t-cell-receptor-activation","display_name":"T cell receptor stimulation","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.9275538325309753},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.5536122918128967},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5166497826576233},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5117528438568115},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.507166862487793},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.4941864311695099},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4670169949531555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45354995131492615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40238112211227417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.367819607257843},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.31417402625083923},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3039684295654297}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008231","descriptor_name":"Lymphopenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008231","descriptor_name":"Lymphopenia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008231","descriptor_name":"Lymphopenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020296","descriptor_name":"Animals, Congenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047889","descriptor_name":"Receptors, Tumor Necrosis Factor, Type II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.4049/jimmunol.1202659","doi":"https://doi.org/10.4049/jimmunol.1202659","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1202659","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:23277487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23277487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2891890","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3552130","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3552130","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3552130","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/117724","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/117724","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/117724","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/117724","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Immunology, 190, 1076 - 84","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2891890","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3552130","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2755035673","display_name":null,"funder_award_id":"Y99 CA999999","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6374948078","display_name":null,"funder_award_id":"Z99 CA999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1486722793","https://openalex.org/W1499979791","https://openalex.org/W1508779235","https://openalex.org/W1509596990","https://openalex.org/W1557037837","https://openalex.org/W1575585006","https://openalex.org/W1594748719","https://openalex.org/W1599910722","https://openalex.org/W1690266756","https://openalex.org/W1885103044","https://openalex.org/W1968295892","https://openalex.org/W1974430505","https://openalex.org/W1979966334","https://openalex.org/W1984113136","https://openalex.org/W1986266083","https://openalex.org/W1995346461","https://openalex.org/W2002344508","https://openalex.org/W2004014851","https://openalex.org/W2010156984","https://openalex.org/W2025761406","https://openalex.org/W2036383793","https://openalex.org/W2043776488","https://openalex.org/W2045343528","https://openalex.org/W2048659881","https://openalex.org/W2051360755","https://openalex.org/W2061915520","https://openalex.org/W2062522397","https://openalex.org/W2068639447","https://openalex.org/W2069569049","https://openalex.org/W2069571875","https://openalex.org/W2084007358","https://openalex.org/W2086595653","https://openalex.org/W2094835614","https://openalex.org/W2097811455","https://openalex.org/W2103180268","https://openalex.org/W2109057661","https://openalex.org/W2110264653","https://openalex.org/W2117989916","https://openalex.org/W2120010406","https://openalex.org/W2123166427","https://openalex.org/W2133247246","https://openalex.org/W2156290301","https://openalex.org/W2159568446","https://openalex.org/W2162124617","https://openalex.org/W2167297937","https://openalex.org/W2168707849","https://openalex.org/W2737785069"],"related_works":["https://openalex.org/W1519228642","https://openalex.org/W2283959831","https://openalex.org/W1511781669","https://openalex.org/W7025122060","https://openalex.org/W3128167313","https://openalex.org/W2980274925","https://openalex.org/W1508779235","https://openalex.org/W2515734925","https://openalex.org/W1510444590","https://openalex.org/W2470430235"],"abstract_inverted_index":{"Several":[0],"lines":[1],"of":[2,7,18,22,32,56,63,96,105,137,151,158,166,181,202,210,221],"evidence":[3],"indicate":[4],"the":[5,20,30,46,60,144,163,167,197,205],"instability":[6],"CD4(+)Foxp3(+)":[8],"regulatory":[9],"T":[10],"cells":[11,140],"(Tregs).":[12],"We":[13,65],"have":[14],"therefore":[15],"investigated":[16],"means":[17],"promoting":[19,59],"stability":[21,201],"Tregs.":[23,128,160],"In":[24,129,176],"this":[25,94],"study,":[26],"we":[27],"found":[28],"that":[29,67,192],"proportion":[31],"Tregs":[33,86,172,183,203],"in":[34,38,45,58,69,162,204],"mouse":[35,85,131],"strains":[36],"deficient":[37],"TNFR2":[39,57,193],"or":[40],"its":[41],"ligands":[42],"was":[43,87,107,119],"reduced":[44],"thymus":[47],"and":[48,76,99,199,223],"peripheral":[49],"lymphoid":[50],"tissues,":[51],"suggesting":[52],"a":[53,130],"potential":[54],"role":[55],"sustained":[61],"expression":[62,81,125],"Foxp3.":[64],"observed":[66],"upon":[68],"vitro":[70],"activation":[71],"with":[72],"plate-bound":[73],"anti-CD3":[74],"Ab":[75],"soluble":[77],"anti-CD28":[78],"Ab,":[79,111],"Foxp3":[80,101,124,174,185],"by":[82,109,114,126,135,149,156,226],"highly":[83],"purified":[84],"markedly":[88],"downregulated.":[89],"Importantly,":[90],"TNF":[91,106,118,211,228],"partially":[92],"abrogated":[93],"effect":[95,104,209],"TCR":[97],"stimulation":[98],"stabilized":[100],"expression.":[102,175,186],"This":[103,208],"blocked":[108],"anti-TNFR2":[110],"but":[112,154],"not":[113,120,155],"anti-TNFR1":[115],"Ab.":[116],"Furthermore,":[117,161],"able":[121],"to":[122],"maintain":[123],"TNFR2-deficient":[127,159,182],"colitis":[132,168],"model":[133],"induced":[134],"transfer":[136],"naive":[138],"CD4":[139],"into":[141,215],"Rag1(-/-)":[142],"mice,":[143],"disease":[145,225],"could":[146],"be":[147,213],"inhibited":[148],"cotransfer":[150,157],"wild-type":[152,171],"Tregs,":[153],"lamina":[164],"propria":[165],"model,":[169],"most":[170],"maintained":[173],"contrast,":[177],"an":[178],"increased":[179],"number":[180],"lost":[184],"Thus,":[187],"our":[188],"data":[189],"clearly":[190],"show":[191],"is":[194],"critical":[195],"for":[196],"phenotypic":[198],"functional":[200],"inflammatory":[206],"environment.":[207],"should":[212],"taken":[214],"account":[216],"when":[217],"designing":[218],"future":[219],"therapy":[220],"autoimmunity":[222],"graft-versus-host":[224],"using":[227],"inhibitors.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}