{"id":"https://openalex.org/W2096064481","doi":"https://doi.org/10.1074/jbc.m700651200","title":"Disruption of the Insulin-like Growth Factor Type 1 Receptor in Osteoblasts Enhances Insulin Signaling and Action","display_name":"Disruption of the Insulin-like Growth Factor Type 1 Receptor in Osteoblasts Enhances Insulin Signaling and Action","publication_year":2007,"publication_date":"2007-06-07","ids":{"openalex":"https://openalex.org/W2096064481","doi":"https://doi.org/10.1074/jbc.m700651200","mag":"2096064481","pmid":"https://pubmed.ncbi.nlm.nih.gov/17553792"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m700651200","doi":"https://doi.org/10.1074/jbc.m700651200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m700651200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m700651200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056622307","display_name":"Keertik S. Fulzele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keertik Fulzele","raw_affiliation_strings":["Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA","Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016202341","display_name":"Douglas J. DiGirolamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas J. DiGirolamo","raw_affiliation_strings":["Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101918196","display_name":"Zhongyu Liu","orcid":"https://orcid.org/0000-0002-2016-2424","observed_orcids":["https://orcid.org/0000-0002-2016-2424"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongyu Liu","raw_affiliation_strings":["Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001749038","display_name":"Jie Hua Xu","orcid":"https://orcid.org/0000-0003-1957-8438","observed_orcids":["https://orcid.org/0000-0003-1957-8438"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Xu","raw_affiliation_strings":["Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027152326","display_name":"Joseph L. Messina","orcid":"https://orcid.org/0000-0003-0759-3745","observed_orcids":["https://orcid.org/0000-0003-0759-3745"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph L. Messina","raw_affiliation_strings":["Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","Veterans Administration Medical Center, Birmingham, Alabama 35233"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Veterans Administration Medical Center, Birmingham, Alabama 35233","institution_ids":["https://openalex.org/I4210115616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108588602","display_name":"Thomas L. Clemens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas L. Clemens","raw_affiliation_strings":["Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","Veterans Administration Medical Center, Birmingham, Alabama 35233"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Veterans Administration Medical Center, Birmingham, Alabama 35233","institution_ids":["https://openalex.org/I4210115616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108588602"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4210115616"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.9709,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.94821668,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"282","issue":"35","first_page":"25649","last_page":"25658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.19519999623298645,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-type-1-receptor","display_name":"insulin-like growth factor type 1 receptor","score":0.9649999737739563},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7820000052452087},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9760000109672546},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.8970000147819519},{"id":"https://openalex.org/keywords/akt-erk-signaling","display_name":"AKT/ERK signaling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.6190000176429749},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.9829999804496765},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7276820540428162},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.689699649810791},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.678322970867157},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.6598134636878967},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.6524431705474854},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5947707891464233},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5256530046463013},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4801896810531616},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.47231101989746094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4633503556251526},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.455971360206604},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.43862831592559814},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4049922525882721},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40214449167251587},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.390461802482605},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.13228604197502136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12038850784301758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07770493626594543},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000963","descriptor_name":"Antimetabolites","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m700651200","doi":"https://doi.org/10.1074/jbc.m700651200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m700651200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17553792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17553792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m700651200","doi":"https://doi.org/10.1074/jbc.m700651200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m700651200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1506695253","https://openalex.org/W1547049402","https://openalex.org/W1585635925","https://openalex.org/W1807852583","https://openalex.org/W1919421236","https://openalex.org/W1965056888","https://openalex.org/W1965110077","https://openalex.org/W1970285990","https://openalex.org/W1978329718","https://openalex.org/W1985807246","https://openalex.org/W1992326265","https://openalex.org/W1998493448","https://openalex.org/W1998761507","https://openalex.org/W2002398354","https://openalex.org/W2011829510","https://openalex.org/W2015651900","https://openalex.org/W2018735721","https://openalex.org/W2019759067","https://openalex.org/W2021942056","https://openalex.org/W2027795688","https://openalex.org/W2033629466","https://openalex.org/W2033815178","https://openalex.org/W2040214384","https://openalex.org/W2051006916","https://openalex.org/W2058096227","https://openalex.org/W2062340542","https://openalex.org/W2067971349","https://openalex.org/W2070624893","https://openalex.org/W2082735845","https://openalex.org/W2085548266","https://openalex.org/W2094542138","https://openalex.org/W2101800552","https://openalex.org/W2108001469","https://openalex.org/W2113777483","https://openalex.org/W2116288435","https://openalex.org/W2120668586","https://openalex.org/W2122393978","https://openalex.org/W2122901687","https://openalex.org/W2123672254","https://openalex.org/W2125688767","https://openalex.org/W2128921346","https://openalex.org/W2131866220","https://openalex.org/W2148258829","https://openalex.org/W2152794772","https://openalex.org/W2155907836","https://openalex.org/W2157209565","https://openalex.org/W2157254321","https://openalex.org/W2164300791","https://openalex.org/W2167561720","https://openalex.org/W2327640792","https://openalex.org/W2526622467","https://openalex.org/W4211075026"],"related_works":["https://openalex.org/W1906021965","https://openalex.org/W2357702515","https://openalex.org/W2068766186","https://openalex.org/W2117517020","https://openalex.org/W2080908190","https://openalex.org/W2350115548","https://openalex.org/W2155907836","https://openalex.org/W4236005383","https://openalex.org/W2104601536","https://openalex.org/W2178944064"],"abstract_inverted_index":{"Defective":[0],"bone":[1],"formation":[2],"is":[3,228],"common":[4],"in":[5,16,34,48,60,151,198,213],"patients":[6],"with":[7,82,167,232],"diabetes,":[8],"suggesting":[9,190],"that":[10,191,207,222],"insulin":[11,20,47,56,106,120,131,168,179,208],"normally":[12],"exerts":[13,209],"anabolic":[14,211],"actions":[15,45,212],"bone.":[17],"However,":[18],"because":[19],"can":[21,194],"cross-activate":[22],"the":[23,42,68,86,182,223,233],"insulin-like":[24],"growth":[25],"factor":[26],"type":[27],"1":[28],"receptor":[29,70,107,132,220],"(IGF-1R),":[30],"which":[31],"also":[32],"functions":[33],"bone,":[35],"it":[36],"has":[37],"been":[38],"difficult":[39],"to":[40,155],"establish":[41],"direct":[43,210],"(IGF-1-independent)":[44],"of":[46,67,98,130,141,158,165,187,202,217,225],"osteoblasts.":[49],"To":[50],"overcome":[51],"this":[52],"problem,":[53],"we":[54],"examined":[55],"signaling":[57,121,193],"and":[58,110,113,135,162,175,185,221],"action":[59],"primary":[61],"osteoblasts":[62,73,147,166,214],"engineered":[63],"for":[64,200],"conditional":[65],"disruption":[66],"IGF-1":[69],"(DeltaIGF-1R).":[71],"Calvarial":[72],"from":[74,144],"mice":[75],"carrying":[76],"floxed":[77],"IGF-1R":[78,99,103,203],"alleles":[79],"were":[80],"infected":[81],"adenoviral":[83],"vectors":[84],"expressing":[85],"Cre":[87],"recombinase":[88],"(Ad-Cre)":[89],"or":[90],"green":[91],"fluorescent":[92],"protein":[93,111],"(Ad-GFP)":[94],"as":[95,125],"control.":[96],"Disruption":[97],"mRNA":[100,109],"(>90%)":[101],"eliminated":[102,114],"without":[104],"affecting":[105],"(IR)":[108],"expression":[112],"IGF-1R/IR":[115],"hybrids.":[116],"In":[117],"DeltaIGF-1R":[118,146,188],"osteoblasts,":[119,189],"was":[122],"markedly":[123],"increased":[124,128,172],"evidenced":[126],"by":[127,215],"phosphorylation":[129],"substrate":[133],"1/2":[134],"enhanced":[136,176],"ERK/Akt":[137],"activation.":[138],"Microarray":[139],"analysis":[140],"RNA":[142],"samples":[143],"insulin-treated,":[145],"revealed":[148],"striking":[149],"changes":[150],"several":[152],"genes":[153],"known":[154],"be":[156],"downstream":[157],"ERK":[159],"including":[160],"Glut-1":[161,170],"c-fos.":[163],"Treatment":[164],"induced":[169],"mRNA,":[171],"2-[1,2-(3)H]-deoxy-d-glucose":[173],"uptake,":[174],"proliferation.":[177],"Moreover,":[178],"treatment":[180],"rescued":[181],"defective":[183],"differentiation":[184],"mineralization":[186],"IR":[192],"compensate,":[195],"at":[196],"least":[197],"part,":[199],"loss":[201],"signaling.":[204],"We":[205],"conclude":[206],"activation":[216],"its":[218],"cognate":[219],"strength":[224],"insulin-generated":[226],"signals":[227],"tempered":[229],"through":[230],"interactions":[231],"IGF-1R.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
