{"id":"https://openalex.org/W2096064097","doi":"https://doi.org/10.1002/hep.24558","title":"Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: A 12-month randomized, prospective, open- label trial","display_name":"Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: A 12-month randomized, prospective, open- label trial","publication_year":2011,"publication_date":"2011-07-11","ids":{"openalex":"https://openalex.org/W2096064097","doi":"https://doi.org/10.1002/hep.24558","mag":"2096064097","pmid":"https://pubmed.ncbi.nlm.nih.gov/21748770"},"language":"en","primary_location":{"id":"doi:10.1002/hep.24558","doi":"https://doi.org/10.1002/hep.24558","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.24558","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24558","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24558","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065339607","display_name":"Dawn McDowell Torres","orcid":"https://orcid.org/0000-0002-8632-0931","observed_orcids":["https://orcid.org/0000-0002-8632-0931"]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn M. Torres","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA","Division of Gastroenterology, Department of Medicine, Walter Reed Army Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Walter Reed Army Medical Center, Washington, DC, USA","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Walter Reed Army Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2800363604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109208753","display_name":"Frances J. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799567722","display_name":"Wilford Hall Ambulatory Surgical Center","ror":"https://ror.org/025m0q735","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2799567722","https://openalex.org/I2802362820","https://openalex.org/I4210102105","https://openalex.org/I4210119345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances J. Jones","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Wilford Hall Medical Center, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Wilford Hall Medical Center, San Antonio, TX","institution_ids":["https://openalex.org/I2799567722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103580245","display_name":"Janet C. Shaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799567722","display_name":"Wilford Hall Ambulatory Surgical Center","ror":"https://ror.org/025m0q735","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2799567722","https://openalex.org/I2802362820","https://openalex.org/I4210102105","https://openalex.org/I4210119345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet C. Shaw","raw_affiliation_strings":["Department of Pathology, Wilford Hall Medical Center, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wilford Hall Medical Center, San Antonio, TX","institution_ids":["https://openalex.org/I2799567722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082589819","display_name":"Christopher David Williams","orcid":"https://orcid.org/0000-0003-0528-3436","observed_orcids":["https://orcid.org/0000-0003-0528-3436"]},"institutions":[{"id":"https://openalex.org/I2799567722","display_name":"Wilford Hall Ambulatory Surgical Center","ror":"https://ror.org/025m0q735","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2799567722","https://openalex.org/I2802362820","https://openalex.org/I4210102105","https://openalex.org/I4210119345"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Williams","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Wilford Hall Medical Center, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Wilford Hall Medical Center, San Antonio, TX","institution_ids":["https://openalex.org/I2799567722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106405926","display_name":"John A. Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289568071","display_name":"Brooke Army Medical Center","ror":"https://ror.org/00m1mwc36","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289568071","https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Ward","raw_affiliation_strings":["Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, TX","institution_ids":["https://openalex.org/I1289568071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091625375","display_name":"Stephen A. Harrison","orcid":"https://orcid.org/0000-0001-8285-2204","observed_orcids":["https://orcid.org/0000-0001-8285-2204","https://orcid.org/0000-0001-6399-5744"]},"institutions":[{"id":"https://openalex.org/I1289568071","display_name":"Brooke Army Medical Center","ror":"https://ror.org/00m1mwc36","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289568071","https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen A. Harrison","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX","fax: 210-916-3195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX","institution_ids":["https://openalex.org/I1289568071"]},{"raw_affiliation_string":"fax: 210-916-3195","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091625375"],"corresponding_institution_ids":["https://openalex.org/I1289568071"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":7.8163,"has_fulltext":true,"cited_by_count":186,"citation_normalized_percentile":{"value":0.98077707,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"54","issue":"5","first_page":"1631","last_page":"1639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.972000002861023},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ballooning-degeneration","display_name":"ballooning degeneration","score":0.8949999809265137},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.9279999732971191},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.7839999794960022},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2780152017","wikidata":"https://www.wikidata.org/wiki/Q424771","display_name":"Rosiglitazone","level":3,"score":0.9909743666648865},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.7754979133605957},{"id":"https://openalex.org/C3018708256","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic steatohepatitis","level":5,"score":0.765426754951477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7580801248550415},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.5587756633758545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5201735496520996},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5088313221931458},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.4873112142086029},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32403564453125},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.18712392449378967},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.17621374130249023},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.07890638709068298},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.06316512823104858},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05489504337310791},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.04414251446723938}],"mesh":[{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.24558","doi":"https://doi.org/10.1002/hep.24558","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.24558","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24558","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:21748770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21748770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1002/hep.24558","doi":"https://doi.org/10.1002/hep.24558","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.24558","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.24558","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096064097.pdf","grobid_xml":"https://content.openalex.org/works/W2096064097.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1034730247","https://openalex.org/W1830680247","https://openalex.org/W1968231063","https://openalex.org/W1968969864","https://openalex.org/W1979443397","https://openalex.org/W1990055069","https://openalex.org/W1994261934","https://openalex.org/W2001837599","https://openalex.org/W2004083442","https://openalex.org/W2009625685","https://openalex.org/W2014804838","https://openalex.org/W2017511982","https://openalex.org/W2025242285","https://openalex.org/W2025843189","https://openalex.org/W2027804378","https://openalex.org/W2034716567","https://openalex.org/W2039800528","https://openalex.org/W2046837981","https://openalex.org/W2054608703","https://openalex.org/W2056609391","https://openalex.org/W2059307783","https://openalex.org/W2062812115","https://openalex.org/W2067740038","https://openalex.org/W2099382390","https://openalex.org/W2100093159","https://openalex.org/W2103156933","https://openalex.org/W2111245313","https://openalex.org/W2120397203","https://openalex.org/W2125963555","https://openalex.org/W2151490108","https://openalex.org/W2157630219","https://openalex.org/W2316193238","https://openalex.org/W2318642323","https://openalex.org/W6793655344"],"related_works":["https://openalex.org/W1990055069","https://openalex.org/W2027353489","https://openalex.org/W3032399801","https://openalex.org/W2388090222","https://openalex.org/W2069412892","https://openalex.org/W4223941107","https://openalex.org/W2009859342","https://openalex.org/W2151490108","https://openalex.org/W1868475579","https://openalex.org/W1996306441"],"abstract_inverted_index":{"UNLABELLED:":[0],"Medication":[1],"combinations":[2],"that":[3],"improve":[4],"the":[5,33,144,155,168],"efficacy":[6,34],"of":[7,14,25,35,52,56,73,77,82,88,94,106,116,127,143,157,242],"thiazolidinediones":[8],"or":[9,85,249],"ameliorate":[10],"weight-gain":[11],"side":[12],"effects":[13],"therapy":[15,128,244],"represent":[16],"an":[17],"attractive":[18],"potential":[19],"treatment":[20,152,177],"for":[21,97,103,149],"(NASH).":[22],"The":[23,140],"aim":[24,142],"this":[26],"randomized,":[27],"open-label":[28],"trial":[29],"was":[30,122,146,206],"to":[31,46,67,147,262],"assess":[32,148],"rosiglitazone":[36,42,47,78,89,246,250,258],"and":[37,43,64,79,91,129,161,204,247,251],"metformin":[38,83,248],"in":[39,114,131,154,179,198,215],"combination":[40,243],"versus":[41],"losartan,":[44],"compared":[45],"alone,":[48],"after":[49,124],"48":[50,98,125],"weeks":[51,126,241],"therapy.":[53],"A":[54],"total":[55],"137":[57],"subjects":[58,166],"with":[59,245,260],"biopsy-proven":[60],"NASH":[61],"were":[62,101,213],"enrolled":[63],"randomly":[65],"assigned":[66],"receive":[68],"either":[69],"4":[70,75,86],"mg":[71,76,81,87,93],"twice-daily":[72,90],"rosiglitazone,":[74],"500":[80],"twice-daily,":[84],"50":[92],"losartan":[95,252],"once-daily":[96],"weeks.":[99],"Patients":[100],"screened":[102],"other":[104],"etiologies":[105],"chronic":[107],"liver":[108,120],"disease,":[109],"including":[110],"daily":[111],"alcohol":[112],"intake":[113],"excess":[115],"20":[117],"g.":[118],"Repeat":[119],"biopsy":[121],"performed":[123],"reviewed":[130],"a":[132,136],"blinded":[133],"fashion":[134],"by":[135],"single":[137],"expert":[138],"hepatopathologist.":[139],"primary":[141],"study":[145],"differences":[150],"between":[151,176,227],"groups":[153,178,218],"improvement":[156,197],"steatosis,":[158,199],"hepatocellular":[159,187,200],"inflammation,":[160,188,201],"fibrosis.":[162],"In":[163],"total,":[164],"108":[165],"completed":[167],"trial.":[169],"Primary":[170],"outcome":[171],"revealed":[172],"no":[173,254],"significant":[174],"difference":[175],"all":[180,216],"histologic":[181],"parameters":[182],"(steatosis,":[183],"P":[184,189,193,224],"=":[185,190,194,237],"0.137;":[186],"0.320;":[191],"fibrosis,":[192],"0.229).":[195],"Overall":[196],"ballooning":[202],"degeneration,":[203],"fibrosis":[205],"observed":[207],"(P":[208,219,236],"\u2264":[209],"0.001).":[210],"Serum":[211],"aminotransferases":[212],"reduced":[214],"three":[217],"<":[220],"0.001":[221],"within":[222],"treatment,":[223],">":[225],"0.05":[226],"groups).":[228],"Metformin":[229],"did":[230],"not":[231],"significantly":[232],"mitigate":[233],"weight":[234],"gain":[235],"0.051).":[238],"CONCLUSIONS:":[239],"Forty-eight":[240],"confers":[253],"greater":[255],"benefit":[256],"than":[257],"alone":[259],"respect":[261],"histopathology.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
