{"id":"https://openalex.org/W2095934571","doi":"https://doi.org/10.1128/mcb.20.22.8602-8612.2000","title":"Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis","display_name":"Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W2095934571","doi":"https://doi.org/10.1128/mcb.20.22.8602-8612.2000","mag":"2095934571","pmid":"https://pubmed.ncbi.nlm.nih.gov/11046155","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/102165"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.20.22.8602-8612.2000","doi":"https://doi.org/10.1128/mcb.20.22.8602-8612.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.20.22.8602-8612.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2095934571"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC102165/pdf/mb008602.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046187780","display_name":"Juan M\u00e9ndez","orcid":"https://orcid.org/0000-0002-3235-2559","observed_orcids":["https://orcid.org/0000-0002-3235-2559"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan M\u00e9ndez","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071437258","display_name":"Bruce Stillman","orcid":"https://orcid.org/0000-0002-9453-4091","observed_orcids":["https://orcid.org/0000-0002-9453-4091"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Stillman","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724","institution_ids":["https://openalex.org/I2750212522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2750212522"],"apc_list":null,"apc_paid":null,"fwci":7.5645,"has_fulltext":true,"cited_by_count":934,"citation_normalized_percentile":{"value":0.98442362,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"20","issue":"22","first_page":"8602","last_page":"8612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.31619998812675476,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.31619998812675476,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.27950000762939453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.25850000977516174,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/origin-recognition-complex","display_name":"origin recognition complex","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cdc6","display_name":"CDC6","score":0.8190000057220459},{"id":"https://openalex.org/keywords/minichromosome-maintenance-proteins","display_name":"minichromosome maintenance proteins","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pre-replication-complex","display_name":"pre-replication complex","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dna-replication-initiation","display_name":"DNA replication initiation","score":0.953000009059906},{"id":"https://openalex.org/keywords/chromatin-association","display_name":"chromatin association","score":0.9240000247955322},{"id":"https://openalex.org/keywords/polyubiquitination","display_name":"polyubiquitination","score":0.7649999856948853},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cyclin-b","display_name":"cyclin B","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mitotic-kinases","display_name":"mitotic kinases","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8486084938049316},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7218630909919739},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7116358280181885},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6876965761184692},{"id":"https://openalex.org/C151158763","wikidata":"https://www.wikidata.org/wiki/Q1626856","display_name":"Origin recognition complex","level":5,"score":0.6666239500045776},{"id":"https://openalex.org/C175248279","wikidata":"https://www.wikidata.org/wiki/Q3858415","display_name":"Minichromosome maintenance","level":5,"score":0.5938246250152588},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.586228609085083},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.4213002324104309},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.41809865832328796},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.3967719078063965},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2435857057571411},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24160489439964294},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.15190911293029785}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007976","descriptor_name":"Leupeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029702","descriptor_name":"Schizosaccharomyces pombe Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051738","descriptor_name":"Origin Recognition Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064111","descriptor_name":"Minichromosome Maintenance Complex Component 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064126","descriptor_name":"Minichromosome Maintenance Complex Component 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064148","descriptor_name":"Minichromosome Maintenance Complex Component 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064151","descriptor_name":"Minichromosome Maintenance Complex Component 6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.20.22.8602-8612.2000","doi":"https://doi.org/10.1128/mcb.20.22.8602-8612.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.20.22.8602-8612.2000","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:102165","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/102165","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC102165/pdf/mb008602.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:1254554","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/102165","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:11046155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11046155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:repository.cshl.edu:25021","doi":null,"is_oa":false,"landing_page_url":"https://repository.cshl.edu/id/eprint/25021/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402288","display_name":"Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Paper"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:102165","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/102165","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC102165/pdf/mb008602.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000856157","display_name":"Targeting Transcription and Splicing in Cancer","funder_award_id":"P01CA013106","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2095934571.pdf","grobid_xml":"https://content.openalex.org/works/W2095934571.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W29290466","https://openalex.org/W560616259","https://openalex.org/W1519389973","https://openalex.org/W1547945395","https://openalex.org/W1576181724","https://openalex.org/W1579608990","https://openalex.org/W1596546557","https://openalex.org/W1601514415","https://openalex.org/W1607626977","https://openalex.org/W1875835053","https://openalex.org/W1928704095","https://openalex.org/W1964429281","https://openalex.org/W1968074226","https://openalex.org/W1968863900","https://openalex.org/W1971017541","https://openalex.org/W1977290507","https://openalex.org/W1983127612","https://openalex.org/W1990520992","https://openalex.org/W1996726991","https://openalex.org/W2001479945","https://openalex.org/W2002223631","https://openalex.org/W2002372083","https://openalex.org/W2008060693","https://openalex.org/W2008136020","https://openalex.org/W2016406045","https://openalex.org/W2017816163","https://openalex.org/W2018782003","https://openalex.org/W2026160273","https://openalex.org/W2029654284","https://openalex.org/W2032141702","https://openalex.org/W2034434494","https://openalex.org/W2035637115","https://openalex.org/W2040778486","https://openalex.org/W2050796617","https://openalex.org/W2052381578","https://openalex.org/W2052566931","https://openalex.org/W2056205588","https://openalex.org/W2056590571","https://openalex.org/W2057051052","https://openalex.org/W2057594508","https://openalex.org/W2059208699","https://openalex.org/W2059594509","https://openalex.org/W2066677001","https://openalex.org/W2068392601","https://openalex.org/W2069607114","https://openalex.org/W2072472133","https://openalex.org/W2080835326","https://openalex.org/W2084189799","https://openalex.org/W2086487735","https://openalex.org/W2088612272","https://openalex.org/W2090985010","https://openalex.org/W2093268779","https://openalex.org/W2093703127","https://openalex.org/W2094178377","https://openalex.org/W2103697688","https://openalex.org/W2105022572","https://openalex.org/W2125905076","https://openalex.org/W2127359546","https://openalex.org/W2128276755","https://openalex.org/W2129781454","https://openalex.org/W2130258750","https://openalex.org/W2134927450","https://openalex.org/W2134954412","https://openalex.org/W2143955948","https://openalex.org/W2147891889","https://openalex.org/W2152053389","https://openalex.org/W2157545784","https://openalex.org/W2170085122","https://openalex.org/W2170326957","https://openalex.org/W2188497916"],"related_works":["https://openalex.org/W2087013595","https://openalex.org/W2116515750","https://openalex.org/W2065703412","https://openalex.org/W1979415657","https://openalex.org/W2039576441","https://openalex.org/W1971017541","https://openalex.org/W2134954412","https://openalex.org/W2049302610","https://openalex.org/W2531518342","https://openalex.org/W3126212514"],"abstract_inverted_index":{"Evidence":[0],"obtained":[1],"from":[2],"studies":[3],"with":[4,160],"yeast":[5],"and":[6,25,47,84,102,114,146],"Xenopus":[7],"indicate":[8],"that":[9,79,167],"the":[10,42,48,90,123,137,161,168],"initiation":[11,38],"of":[12,44,54,57,63,72,130,150,163],"DNA":[13],"replication":[14,59],"is":[15,39,116,132],"a":[16,127],"multistep":[17],"process.":[18],"The":[19,52],"origin":[20],"recognition":[21],"complex":[22,174],"(ORC),":[23],"Cdc6p,":[24],"minichromosome":[26],"maintenance":[27],"(MCM)":[28],"proteins":[29,60,86,142,152],"are":[30,87],"required":[31],"for":[32,125],"establishing":[33],"prereplication":[34,173],"complexes,":[35],"upon":[36],"which":[37],"triggered":[40],"by":[41,118],"activation":[43],"cyclin-dependent":[45],"kinases":[46],"Dbf4p-dependent":[49],"kinase":[50,170],"Cdc7p.":[51],"identification":[53],"human":[55,74,81,177],"homologues":[56],"these":[58],"allows":[61],"investigation":[62],"S-phase":[64],"regulation":[65],"in":[66,99,112,156,176],"mammalian":[67],"cells.":[68,178],"Using":[69],"centrifugal":[70],"elutriation":[71],"several":[73],"cell":[75,91,138],"lines,":[76],"we":[77],"demonstrate":[78],"whereas":[80,140],"Orc2":[82],"(hOrc2p)":[83],"hMcm":[85,141,151],"present":[88,133],"throughout":[89,136],"cycle,":[92,139],"hCdc6p":[93,108,131],"levels":[94],"vary,":[95],"being":[96],"very":[97],"low":[98],"early":[100],"G(1)":[101],"accumulating":[103],"until":[104],"cells":[105],"enter":[106],"mitosis.":[107],"can":[109],"be":[110],"polyubiquitinated":[111],"vivo,":[113],"it":[115],"stabilized":[117],"proteasome":[119],"inhibitors.":[120],"Similar":[121],"to":[122],"case":[124],"hOrc2p,":[126],"significant":[128],"fraction":[129],"on":[134],"chromatin":[135,154],"alternate":[143],"between":[144],"soluble":[145],"chromatin-bound":[147],"forms.":[148],"Loading":[149],"onto":[153],"occurs":[155],"late":[157],"mitosis":[158],"concomitant":[159],"destruction":[162],"cyclin":[164],"B,":[165],"indicating":[166],"mitotic":[169],"activity":[171],"inhibits":[172],"formation":[175]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":36},{"year":2018,"cited_by_count":38},{"year":2017,"cited_by_count":36},{"year":2016,"cited_by_count":47},{"year":2015,"cited_by_count":42},{"year":2014,"cited_by_count":58},{"year":2013,"cited_by_count":49},{"year":2012,"cited_by_count":48}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}