{"id":"https://openalex.org/W2095869995","doi":"https://doi.org/10.1002/j.1460-2075.1995.tb07082.x","title":"Crystal structure of casein kinase\u20101, a phosphate\u2010directed protein kinase.","display_name":"Crystal structure of casein kinase\u20101, a phosphate\u2010directed protein kinase.","publication_year":1995,"publication_date":"1995-03-01","ids":{"openalex":"https://openalex.org/W2095869995","doi":"https://doi.org/10.1002/j.1460-2075.1995.tb07082.x","mag":"2095869995","pmid":"https://pubmed.ncbi.nlm.nih.gov/7889932","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/398173"},"language":"en","primary_location":{"id":"doi:10.1002/j.1460-2075.1995.tb07082.x","doi":"https://doi.org/10.1002/j.1460-2075.1995.tb07082.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1995.tb07082.x","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/398173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054158659","display_name":"Rui-Ming Xu","orcid":"https://orcid.org/0000-0002-5948-8579","observed_orcids":["https://orcid.org/0000-0002-5948-8579"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.M. Xu","raw_affiliation_strings":["W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000871276","display_name":"Gilles Carmel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Carmel","raw_affiliation_strings":["W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113512042","display_name":"R.M. Sweet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.M. Sweet","raw_affiliation_strings":["W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004840529","display_name":"Jeff Kuret","orcid":"https://orcid.org/0000-0002-8083-8406","observed_orcids":["https://orcid.org/0000-0002-8083-8406"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Kuret","raw_affiliation_strings":["W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028895511","display_name":"Xiaodong Cheng","orcid":"https://orcid.org/0000-0002-6967-6362","observed_orcids":["https://orcid.org/0000-0002-6967-6362","https://orcid.org/0000-0003-0702-8201"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Cheng","raw_affiliation_strings":["W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724","institution_ids":["https://openalex.org/I2750212522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2750212522"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":4.98,"has_fulltext":false,"cited_by_count":192,"citation_normalized_percentile":{"value":0.96603106,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"5","first_page":"1015","last_page":"1023"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.13210000097751617,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.08340000361204147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/casein-kinase-1","display_name":"casein kinase 1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/schizosaccharomyces-pombe","display_name":"Schizosaccharomyces pombe","score":0.9810000061988831},{"id":"https://openalex.org/keywords/atp-bound-conformation","display_name":"ATP-bound conformation","score":0.597000002861023},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.8679999709129333},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/peptide-binding-site","display_name":"peptide binding site","score":0.6899999976158142},{"id":"https://openalex.org/keywords/surface-loops","display_name":"surface loops","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C2778712887","wikidata":"https://www.wikidata.org/wiki/Q102836","display_name":"Spring (device)","level":2,"score":0.4376862049102783},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.4222258925437927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4165372848510742},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3573139011859894},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3136650621891022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1027311384677887},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08492165803909302},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012568","descriptor_name":"Schizosaccharomyces","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047388","descriptor_name":"Casein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/j.1460-2075.1995.tb07082.x","doi":"https://doi.org/10.1002/j.1460-2075.1995.tb07082.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1995.tb07082.x","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:398173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/398173","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:7889932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7889932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:398173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/398173","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2695800041","display_name":"ACS SYMPOSIUM OF 'FLUORESCENT CHEMOSENSORS'","funder_award_id":"R13GM048216","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3949215816","display_name":"3D STRUCTURE OF THE CYCLIC AMP DEPENDENT PROTEIN KINASE","funder_award_id":"R01GM044806","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W94095845","https://openalex.org/W207171227","https://openalex.org/W1486704577","https://openalex.org/W1532399000","https://openalex.org/W1542016002","https://openalex.org/W1544709959","https://openalex.org/W1557525759","https://openalex.org/W1561009476","https://openalex.org/W1583504083","https://openalex.org/W1588550310","https://openalex.org/W1594985705","https://openalex.org/W1656503843","https://openalex.org/W1866820856","https://openalex.org/W1942192923","https://openalex.org/W1942971202","https://openalex.org/W1974548484","https://openalex.org/W1978696795","https://openalex.org/W1988369394","https://openalex.org/W1990007361","https://openalex.org/W2003905487","https://openalex.org/W2008708467","https://openalex.org/W2012599652","https://openalex.org/W2013083986","https://openalex.org/W2013417617","https://openalex.org/W2015956088","https://openalex.org/W2020257412","https://openalex.org/W2033450518","https://openalex.org/W2037023383","https://openalex.org/W2049902088","https://openalex.org/W2052221882","https://openalex.org/W2064685101","https://openalex.org/W2067405360","https://openalex.org/W2072742856","https://openalex.org/W2077762082","https://openalex.org/W2083461276","https://openalex.org/W2088345550","https://openalex.org/W2091455173","https://openalex.org/W2095641089","https://openalex.org/W2097801967","https://openalex.org/W2106315897","https://openalex.org/W2107820133","https://openalex.org/W2120810427","https://openalex.org/W2148308294","https://openalex.org/W2283841520","https://openalex.org/W2423881708"],"related_works":["https://openalex.org/W2154143571","https://openalex.org/W2042314648","https://openalex.org/W1973847879","https://openalex.org/W1970153653","https://openalex.org/W2023196077","https://openalex.org/W2116595065","https://openalex.org/W2018355587","https://openalex.org/W1656503843","https://openalex.org/W2146593541","https://openalex.org/W2031247497"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}