{"id":"https://openalex.org/W2095847653","doi":"https://doi.org/10.1016/0165-0327(88)90075-4","title":"Predictors of therapeutic benefit from amitriptyline in mild depression: a general practice placebo-controlled trial","display_name":"Predictors of therapeutic benefit from amitriptyline in mild depression: a general practice placebo-controlled trial","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2095847653","doi":"https://doi.org/10.1016/0165-0327(88)90075-4","mag":"2095847653","pmid":"https://pubmed.ncbi.nlm.nih.gov/2963054"},"language":"en","primary_location":{"id":"doi:10.1016/0165-0327(88)90075-4","doi":"https://doi.org/10.1016/0165-0327(88)90075-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-0327(88)90075-4","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040129792","display_name":"Eugene S. Paykel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"E.S. Paykel","raw_affiliation_strings":["Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, U.K","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108211231","display_name":"J. A. Hollyman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.A. Hollyman","raw_affiliation_strings":["University of Cambridge and St. George's Hospital Medical School, London, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge and St. George's Hospital Medical School, London, U.K","institution_ids":["https://openalex.org/I165862685","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084928129","display_name":"PAUL FREELING","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Freeling","raw_affiliation_strings":["University of Cambridge and St. George's Hospital Medical School, London, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge and St. George's Hospital Medical School, London, U.K","institution_ids":["https://openalex.org/I165862685","https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002849548","display_name":"Philip Martin Sedgwick","orcid":"https://orcid.org/0000-0001-8859-2175","observed_orcids":["https://orcid.org/0000-0001-8859-2175"]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Sedgwick","raw_affiliation_strings":["University of Cambridge and St. George's Hospital Medical School, London, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge and St. George's Hospital Medical School, London, U.K","institution_ids":["https://openalex.org/I165862685","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040129792"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":9.0747,"has_fulltext":false,"cited_by_count":271,"citation_normalized_percentile":{"value":0.98474314,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"1","first_page":"83","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10272","display_name":"Mental Health Treatment and Access","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":1.0},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mild-depression","display_name":"mild depression","score":0.9900000095367432},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.722000002861023},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.75},{"id":"https://openalex.org/keywords/melancholic-depression","display_name":"endogenous depression","score":0.8659999966621399},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.4830000102519989},{"id":"https://openalex.org/keywords/minor-depression","display_name":"minor depression","score":0.5799999833106995},{"id":"https://openalex.org/keywords/general-practice-patients","display_name":"general practice patients","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.9528588056564331},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8946242332458496},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7177366018295288},{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.6396986842155457},{"id":"https://openalex.org/C2993089816","wikidata":"https://www.wikidata.org/wiki/Q385555","display_name":"Hamilton depression scale","level":4,"score":0.556681752204895},{"id":"https://openalex.org/C49467328","wikidata":"https://www.wikidata.org/wiki/Q5376333","display_name":"Endogenous depression","level":3,"score":0.555698037147522},{"id":"https://openalex.org/C2992459003","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo response","level":4,"score":0.5391542911529541},{"id":"https://openalex.org/C2780783166","wikidata":"https://www.wikidata.org/wiki/Q192077","display_name":"Melancholia","level":3,"score":0.4666006565093994},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46481141448020935},{"id":"https://openalex.org/C2779657639","wikidata":"https://www.wikidata.org/wiki/Q908843","display_name":"Tricyclic antidepressant","level":4,"score":0.46437397599220276},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4434799253940582},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.4382197856903076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39333269000053406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3829731345176697},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.333344042301178},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11061152815818787},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.1079883873462677},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.0577796995639801},{"id":"https://openalex.org/C2777198177","wikidata":"https://www.wikidata.org/wiki/Q3765927","display_name":"Hamd","level":3,"score":0.0550977885723114},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000639","descriptor_name":"Amitriptyline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011581","descriptor_name":"Psychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0165-0327(88)90075-4","doi":"https://doi.org/10.1016/0165-0327(88)90075-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-0327(88)90075-4","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},{"id":"pmid:2963054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2963054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of affective disorders","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W70211524","https://openalex.org/W336066835","https://openalex.org/W1964791906","https://openalex.org/W1965373357","https://openalex.org/W1969731042","https://openalex.org/W1972759971","https://openalex.org/W1973178067","https://openalex.org/W1977337531","https://openalex.org/W1985109302","https://openalex.org/W1987587908","https://openalex.org/W1995003813","https://openalex.org/W2001464528","https://openalex.org/W2004778153","https://openalex.org/W2015333384","https://openalex.org/W2017385998","https://openalex.org/W2017810918","https://openalex.org/W2017925175","https://openalex.org/W2019151922","https://openalex.org/W2020785972","https://openalex.org/W2023482691","https://openalex.org/W2049165791","https://openalex.org/W2049939290","https://openalex.org/W2051224229","https://openalex.org/W2056635799","https://openalex.org/W2060956300","https://openalex.org/W2061378977","https://openalex.org/W2067378352","https://openalex.org/W2083342640","https://openalex.org/W2092454479","https://openalex.org/W2103990085","https://openalex.org/W2117250526","https://openalex.org/W2126504999","https://openalex.org/W2131378889","https://openalex.org/W2138776698","https://openalex.org/W2138904478","https://openalex.org/W2147391344","https://openalex.org/W2154882380","https://openalex.org/W2157106791","https://openalex.org/W2157735838","https://openalex.org/W2161837239","https://openalex.org/W2166867603","https://openalex.org/W2168468239","https://openalex.org/W2171413067","https://openalex.org/W2304283757","https://openalex.org/W2316227341","https://openalex.org/W2332289872","https://openalex.org/W2609540526","https://openalex.org/W2764362690","https://openalex.org/W2976707855"],"related_works":["https://openalex.org/W2054826326","https://openalex.org/W70211524","https://openalex.org/W2130590626","https://openalex.org/W2019386069","https://openalex.org/W2057339790","https://openalex.org/W2147391344","https://openalex.org/W2993542566","https://openalex.org/W2043472951","https://openalex.org/W2413808802","https://openalex.org/W129102468"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
