{"id":"https://openalex.org/W2095843353","doi":null,"title":"Influence of glutathione S-transferases on cellular glutathione determination by flow cytometry using monochlorobimane.","display_name":"Influence of glutathione S-transferases on cellular glutathione determination by flow cytometry using monochlorobimane.","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W2095843353","mag":"2095843353","pmid":"https://pubmed.ncbi.nlm.nih.gov/2004362"},"language":"en","primary_location":{"id":"pmid:2004362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2004362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050186199","display_name":"Gregg A. Ublacker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G A Ublacker","raw_affiliation_strings":["Department of Human Oncology, University of Wisconsin-Madison 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, University of Wisconsin-Madison 53792","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043096547","display_name":"Jeffrey Allan Johnson","orcid":"https://orcid.org/0000-0002-3315-7210","observed_orcids":["https://orcid.org/0000-0002-3315-7210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071169246","display_name":"Frances Lea Siegel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F L Siegel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"R T Mulcahy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R T Mulcahy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8913,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.86316027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"51","issue":"7","first_page":"1783","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/monochlorobimane","display_name":"monochlorobimane","score":0.9750000238418579},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"flow cytometry","score":0.6129999756813049},{"id":"https://openalex.org/keywords/gst-isozymes","display_name":"GST isozymes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/glutathione-s-transferase-pi","display_name":"glutathione S-transferase pi","score":0.8759999871253967},{"id":"https://openalex.org/keywords/buthionine-sulfoximine","display_name":"buthionine sulfoximine","score":0.8360000252723694},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.7269999980926514},{"id":"https://openalex.org/keywords/michaelis-menten-kinetics","display_name":"Michaelis-Menten kinetics","score":0.8220000267028809},{"id":"https://openalex.org/keywords/human-cancer-cell-lines","display_name":"human cancer cell lines","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.8923138380050659},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.8258877992630005},{"id":"https://openalex.org/C2777476445","wikidata":"https://www.wikidata.org/wiki/Q5002519","display_name":"Buthionine sulfoximine","level":4,"score":0.6913508176803589},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6902638673782349},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6826373338699341},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5664122700691223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5343016982078552},{"id":"https://openalex.org/C2776907368","wikidata":"https://www.wikidata.org/wiki/Q307302","display_name":"Glutathione S-transferase","level":4,"score":0.5248251557350159},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46828410029411316},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4170064628124237},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3463674783706665},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2307954728603363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07379195094108582}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2004362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2004362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},{"id":"mag:2095843353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2004362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4983077133","display_name":"RADIATION SENSITIZERS--INTERACTIONS","funder_award_id":"R01CA042325","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5936615827","display_name":"ENZYMATIC N-METHYLATION OF CALMODULIN","funder_award_id":"R01NS024969","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8393642451","display_name":"CALMODULIN-STIMULATED PROTEIN METHYLATION","funder_award_id":"R01GM038497","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W233820388","https://openalex.org/W1481581408","https://openalex.org/W1499700118","https://openalex.org/W1535828429","https://openalex.org/W1568679470","https://openalex.org/W1581414347","https://openalex.org/W1584758982","https://openalex.org/W1591606005","https://openalex.org/W1594352829","https://openalex.org/W1775749144","https://openalex.org/W1940169030","https://openalex.org/W1953101143","https://openalex.org/W1964223606","https://openalex.org/W2007064404","https://openalex.org/W2013478379","https://openalex.org/W2026261400","https://openalex.org/W2027065599","https://openalex.org/W2045653027","https://openalex.org/W2048625537","https://openalex.org/W2062381728","https://openalex.org/W2093958715","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2164014307","https://openalex.org/W2167120728","https://openalex.org/W4299166738"],"related_works":["https://openalex.org/W1488610309","https://openalex.org/W6922364614","https://openalex.org/W3213577626","https://openalex.org/W7097004082","https://openalex.org/W2164014307","https://openalex.org/W2093958715","https://openalex.org/W1574844139","https://openalex.org/W2062927875","https://openalex.org/W2023941181","https://openalex.org/W1940169030"],"abstract_inverted_index":{"Intracellular":[0],"glutathione":[1,109],"(GSH)":[2],"levels":[3,33,55,307],"for":[4,43,66,119,254,270],"seven":[5],"mammalian":[6],"cell":[7,123,144,170,296],"lines":[8,49,69,89,145,171],"(four":[9],"human":[10,86,137,168,188,279],"tumors,":[11],"two":[12,47,62],"rodent,":[13],"one":[14],"monkey)":[15],"were":[16,29,98,117],"determined":[17,56,118],"by":[18,35,74,93,101,201,226],"flow":[19],"cytometry":[20,268],"following":[21,70],"staining":[22,106],"with":[23,31,53,127,178,278,316],"monochlorobimane":[24],"(MBCl),":[25],"and":[26,87,113,134,136,152,172,198,205,207,210,218,241,246,308,312],"the":[27,36,46,61,67,78,85,122,142,162,167,194,202,227,236,255,266],"results":[28],"compared":[30],"GSH":[32,54,73,81,199,240,271,306,321],"measured":[34],"Tietze":[37],"assay.":[38],"The":[39],"mean":[40],"fluorescence":[41],"intensity":[42],"all":[44],"but":[45,77],"rodent":[48,68,143],"did":[50],"not":[51,99],"correlate":[52],"biochemically.":[57],"Good":[58],"agreement":[59],"between":[60],"assays":[63,319],"was":[64,90,161,215,224],"observed":[65],"depletion":[71,82],"of":[72,80,121,196,239,261,283,305,320],"buthionine":[75],"sulfoximine,":[76],"level":[79],"achieved":[83],"in":[84,166],"monkey":[88,174],"always":[91],"underestimated":[92],"MBCl/flow":[94,267],"cytometry.":[95],"These":[96,232],"discrepancies":[97],"resolved":[100],"increasing":[102],"stain":[103],"concentration":[104],"or":[105],"time.":[107],"Total":[108],"S-transferase":[110],"(GST)":[111],"activity":[112],"GST":[114,191,213,228,309],"isozyme":[115,164,244,263,310],"profiles":[116],"each":[120],"lines.":[124],"Western":[125],"analysis":[126,177],"antibodies":[128],"raised":[129],"against":[130],"rat":[131,182],"Ya,":[132],"Yb1,":[133],"Yc":[135,150],"pi":[138,229,256],"isozymes":[139,214],"revealed":[140,192],"that":[141,193,235,247],"expressed":[146],"abundant":[147],"alpha":[148,203],"(Ya,":[149],"subunits)":[151,155],"mu":[153,208],"(Yb1":[154],"class":[156,212],"isozymes.":[157],"In":[158],"contrast,":[159],"GST-pi":[160,291],"predominant":[163],"detected":[165],"tumor":[169,280],"Cos-7":[173],"cells.":[175],"Michaelis-Menten":[176],"purified":[179,187],"GSTs":[180],"from":[181],"liver":[183],"as":[184,186],"well":[185],"placental":[189],"(pi)":[190],"conjugation":[195,225,238],"MBCl":[197,242,248],"catalyzed":[200],"(1-1":[204],"2-2)":[206],"(3-3":[209],"3-4)":[211],"approximately":[216],"10":[217],"80":[219],"times":[220],"more":[221],"efficient":[222],"than":[223],"form,":[230],"respectively.":[231],"data":[233],"indicate":[234],"GST-catalyzed":[237],"is":[243,249],"dependent":[245],"a":[250,259],"relatively":[251],"poor":[252],"substrate":[253],"isozyme.":[257],"As":[258],"consequence":[260],"this":[262],"rate":[264],"differential,":[265],"technique":[269],"quantitation":[272],"must":[273],"be":[274,300],"applied":[275],"cautiously,":[276],"particularly":[277],"cells,":[281],"many":[282],"which":[284],"have":[285,289],"been":[286],"shown":[287],"to":[288,294],"high":[290],"activity.":[292],"Application":[293],"other":[295,317],"types":[297],"should":[298],"also":[299],"made":[301],"after":[302,314],"careful":[303],"characterization":[304],"composition":[311],"only":[313],"comparison":[315],"independent":[318],"concentration.":[322]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
