{"id":"https://openalex.org/W2095833129","doi":"https://doi.org/10.1152/ajpendo.1999.277.3.e561","title":"Subcutaneous glucose predicts plasma glucose independent of insulin: implications for continuous monitoring","display_name":"Subcutaneous glucose predicts plasma glucose independent of insulin: implications for continuous monitoring","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2095833129","doi":"https://doi.org/10.1152/ajpendo.1999.277.3.e561","mag":"2095833129","pmid":"https://pubmed.ncbi.nlm.nih.gov/10484370"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.1999.277.3.e561","doi":"https://doi.org/10.1152/ajpendo.1999.277.3.e561","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1999.277.3.e561","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090683438","display_name":"Kerstin Rebrin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerstin Rebrin","raw_affiliation_strings":["MiniMed Incorporated, Sylmar, California 91342; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MiniMed Incorporated, Sylmar, California 91342; and the","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070771680","display_name":"Garry M. Steil","orcid":"https://orcid.org/0000-0001-5418-5256","observed_orcids":["https://orcid.org/0000-0001-5418-5256"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garry M. Steil","raw_affiliation_strings":["Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079812434","display_name":"William P. van Antwerp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William P. van Antwerp","raw_affiliation_strings":["MiniMed Incorporated, Sylmar, California 91342; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MiniMed Incorporated, Sylmar, California 91342; and the","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108062410","display_name":"John J. Mastrototaro","orcid":"https://orcid.org/0009-0005-1579-4098","observed_orcids":["https://orcid.org/0009-0005-1579-4098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John J. Mastrototaro","raw_affiliation_strings":["MiniMed Incorporated, Sylmar, California 91342; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MiniMed Incorporated, Sylmar, California 91342; and the","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.3788,"has_fulltext":false,"cited_by_count":367,"citation_normalized_percentile":{"value":0.97865469,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"277","issue":"3","first_page":"E561","last_page":"E571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-glucose","display_name":"plasma glucose","score":0.8180000185966492},{"id":"https://openalex.org/keywords/continuous-glucose-monitoring","display_name":"continuous glucose monitoring","score":0.8560000061988831},{"id":"https://openalex.org/keywords/amperometric-glucose-biosensor","display_name":"amperometric glucose sensor","score":0.9459999799728394},{"id":"https://openalex.org/keywords/sensor-sensitivity","display_name":"sensor sensitivity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.597000002861023},{"id":"https://openalex.org/keywords/hyperglycemic-clamp","display_name":"hyperglycemic clamp","score":0.8989999890327454},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7506518363952637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7070282697677612},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6439211964607239},{"id":"https://openalex.org/C3020574416","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Plasma glucose","level":3,"score":0.5932664275169373},{"id":"https://openalex.org/C2779822359","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Interstitial fluid","level":2,"score":0.5705514550209045},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.5457798838615417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5366060137748718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4021751880645752},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.26245254278182983}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpendo.1999.277.3.e561","doi":"https://doi.org/10.1152/ajpendo.1999.277.3.e561","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1999.277.3.e561","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:10484370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10484370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6347910165","display_name":null,"funder_award_id":"R01-DK-55337-01","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7271960879","display_name":"INTERSTITIAL GLUCOSE DYNAMICS USING A GLUCOSE SENSOR","funder_award_id":"R01DK055337","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W56129898","https://openalex.org/W388668136","https://openalex.org/W1506809288","https://openalex.org/W1963667250","https://openalex.org/W1964063750","https://openalex.org/W1967723791","https://openalex.org/W1970239649","https://openalex.org/W1971694648","https://openalex.org/W1978939860","https://openalex.org/W1981656807","https://openalex.org/W1981845243","https://openalex.org/W1983131576","https://openalex.org/W1994931701","https://openalex.org/W1995403585","https://openalex.org/W1998941308","https://openalex.org/W2005018313","https://openalex.org/W2009504985","https://openalex.org/W2009880265","https://openalex.org/W2011922821","https://openalex.org/W2012144097","https://openalex.org/W2027249615","https://openalex.org/W2027834220","https://openalex.org/W2034743887","https://openalex.org/W2052051401","https://openalex.org/W2056016152","https://openalex.org/W2068127732","https://openalex.org/W2074463129","https://openalex.org/W2076234874","https://openalex.org/W2087401269","https://openalex.org/W2090817354","https://openalex.org/W2095156968","https://openalex.org/W2096026617","https://openalex.org/W2134233218","https://openalex.org/W2168986956","https://openalex.org/W2187766168","https://openalex.org/W2339679741","https://openalex.org/W2407109074","https://openalex.org/W2410681887","https://openalex.org/W2412790862","https://openalex.org/W2443337383","https://openalex.org/W4318599507"],"related_works":["https://openalex.org/W7101083911","https://openalex.org/W2028294547","https://openalex.org/W2120066601","https://openalex.org/W2415982969","https://openalex.org/W1966352630","https://openalex.org/W2142534938","https://openalex.org/W2147302321","https://openalex.org/W1970611216","https://openalex.org/W1975558907","https://openalex.org/W2618513606"],"abstract_inverted_index":{"The":[0,27],"present":[1],"study":[2],"investigated":[3],"the":[4,72,77,130,188],"relationship":[5,189],"between":[6,190],"blood":[7,191],"and":[8,31,80,91,139,192,200],"subcutaneous":[9],"interstitial":[10],"fluid":[11],"(ISF)":[12],"glucose":[13,18,25,33,82,154,158,194,205],"by":[14,101,198],"employing":[15],"an":[16,61],"amperometric":[17],"sensor":[19,29,66,78],"specifically":[20],"developed":[21],"for":[22,151,161,168,171],"3-day":[23],"continuous":[24],"monitoring.":[26],"apparent":[28],"sensitivity":[30,79],"ISF":[32,81,193,204],"equilibration":[34,206],"delay":[35,83,131],"were":[36,84],"estimated":[37],"on":[38],"separate":[39],"days":[40],"during":[41],"hyperglycemic":[42],"clamps":[43],"in":[44,47,103,203],"four":[45],"dogs":[46],"which":[48],"insulin":[49,75,117,199],"was":[50,69,98,129,178],"either":[51],"suppressed":[52],"with":[53,60,183,210],"somatostatin,":[54],"allowed":[55,70],"to":[56],"change,":[57],"or":[58,115],"increased":[59],"exogenous":[62,116],"infusion.":[63],"A":[64],"2-h":[65],"\"settling-in\"":[67],"period":[68],"before":[71],"clamps.":[73],"During":[74],"deficiency,":[76],"0.23":[85],"+/-":[86,93,106,110,119,123,133,137,141,145],"0.03":[87],"nA":[88,112,125],"per":[89,113,126],"mg/dl":[90],"4.4":[92],"0.":[94],"8":[95],"min.":[96],"Sensitivity":[97],"not":[99,196],"affected":[100,197],"increases":[102],"endogenous":[104],"(0.30":[105],"0.04":[107,111],"vs.":[108,121,135,143],"0.28":[109],"mg/dl)":[114,127],"(0.18":[118],"0.01":[120,124],"0.16":[122],"nor":[128],"(3.3":[132],"1.2":[134],"5.7":[136],"1.1":[138],"9.2":[140],"2.6":[142],"12.3":[144],"1.7":[146],"min;":[147],"P":[148],">":[149,166],"0.05":[150],"all).":[152],"Sensor":[153],"accurately":[155],"predicted":[156],"plasma":[157],"without":[159],"correcting":[160],"delays":[162,173,202],"<10":[163],"min":[164],"(r":[165,180],"0.9":[167],"all),":[169],"whereas":[170],"longer":[172],"a":[174],"digital":[175,211],"corrective":[176],"filter":[177],"used":[179],"=":[181],"0.91":[182],"filter).":[184],"We":[185],"conclude":[186],"that":[187,201],"is":[195],"can":[207],"be":[208],"corrected":[209],"filters.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":19}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
