{"id":"https://openalex.org/W2095791535","doi":"https://doi.org/10.1016/j.otohns.2006.11.027","title":"Epstein\u2010Barr virus DNA detection in the diagnosis of nasopharyngeal carcinoma","display_name":"Epstein\u2010Barr virus DNA detection in the diagnosis of nasopharyngeal carcinoma","publication_year":2007,"publication_date":"2007-06-01","ids":{"openalex":"https://openalex.org/W2095791535","doi":"https://doi.org/10.1016/j.otohns.2006.11.027","mag":"2095791535","pmid":"https://pubmed.ncbi.nlm.nih.gov/17547993"},"language":"en","primary_location":{"id":"doi:10.1016/j.otohns.2006.11.027","doi":"https://doi.org/10.1016/j.otohns.2006.11.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.otohns.2006.11.027","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113638063","display_name":"Yoke\u2010Yeow Yap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Yoke\u2010Yeow Yap","raw_affiliation_strings":["Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang","Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang","institution_ids":["https://openalex.org/I130343225"]},{"raw_affiliation_string":"Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102881678","display_name":"Shahid Hassan","orcid":"https://orcid.org/0000-0003-2982-660X","observed_orcids":["https://orcid.org/0000-0003-2982-660X"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Shahid Hassan","raw_affiliation_strings":["School of Medical Sciences Universiti Sains Malaysia Kelantan","School of Medical Sciences; Universiti Sains Malaysia; Kelantan Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Sciences Universiti Sains Malaysia Kelantan","institution_ids":["https://openalex.org/I139322472"]},{"raw_affiliation_string":"School of Medical Sciences; Universiti Sains Malaysia; Kelantan Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077421323","display_name":"Melissa Sue Ann Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Melissa Chan","raw_affiliation_strings":["School of Medical Sciences Universiti Sains Malaysia Kelantan","School of Medical Sciences; Universiti Sains Malaysia; Kelantan Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Sciences Universiti Sains Malaysia Kelantan","institution_ids":["https://openalex.org/I139322472"]},{"raw_affiliation_string":"School of Medical Sciences; Universiti Sains Malaysia; Kelantan Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008336462","display_name":"Pua Kin Choo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800727921","display_name":"Hospital Pulau Pinang","ror":"https://ror.org/024g0n729","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I2800727921"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Pua Kin Choo","raw_affiliation_strings":["Hospital Pulau Pinang, Pulau Pinang, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Pulau Pinang, Pulau Pinang, Malaysia","institution_ids":["https://openalex.org/I2800727921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059350548","display_name":"Manickam Ravichandran","orcid":"https://orcid.org/0000-0001-5321-1344","observed_orcids":["https://orcid.org/0000-0001-5321-1344"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Manickam Ravichandran","raw_affiliation_strings":["School of Medical Sciences Universiti Sains Malaysia Kelantan","School of Medical Sciences; Universiti Sains Malaysia; Kelantan Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Sciences Universiti Sains Malaysia Kelantan","institution_ids":["https://openalex.org/I139322472"]},{"raw_affiliation_string":"School of Medical Sciences; Universiti Sains Malaysia; Kelantan Malaysia","institution_ids":["https://openalex.org/I139322472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":1.0652,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.77260613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"136","issue":"6","first_page":"986","last_page":"991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.16609999537467957,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13314","display_name":"Lymphadenopathy Diagnosis and Analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ebna1","display_name":"EBNA1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ebna2","display_name":"EBNA2","score":1.0},{"id":"https://openalex.org/keywords/nasopharyngeal-biopsy","display_name":"nasopharyngeal biopsy","score":0.8669999837875366},{"id":"https://openalex.org/keywords/fine-needle-aspiration","display_name":"fine-needle aspiration","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neck-mass","display_name":"neck mass","score":0.7599999904632568},{"id":"https://openalex.org/keywords/diagnostic-sensitivity","display_name":"diagnostic sensitivity","score":0.6549999713897705},{"id":"https://openalex.org/keywords/histopathological-comparison","display_name":"histopathology comparison","score":0.6819999814033508},{"id":"https://openalex.org/keywords/occult-primary-tumor","display_name":"occult primary tumor","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.9129084348678589},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49381574988365173},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4626155495643616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42704644799232483},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.186763733625412},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.04973331093788147}],"mesh":[{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009305","descriptor_name":"Nasopharynx","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D044963","descriptor_name":"Biopsy, Fine-Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.otohns.2006.11.027","doi":"https://doi.org/10.1016/j.otohns.2006.11.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.otohns.2006.11.027","pdf_url":null,"source":{"id":"https://openalex.org/S200877091","display_name":"Otolaryngology","issn_l":"0161-6439","issn":["0161-6439","0194-5998","1085-8679","1097-6817"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology\u2013Head and Neck Surgery","raw_type":"journal-article"},{"id":"pmid:17547993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17547993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1481993304","https://openalex.org/W1979444478","https://openalex.org/W2001133468","https://openalex.org/W2001138540","https://openalex.org/W2032720590","https://openalex.org/W2043349116","https://openalex.org/W2069042623","https://openalex.org/W2069566008","https://openalex.org/W2168593891","https://openalex.org/W2342207742","https://openalex.org/W2395673577","https://openalex.org/W2408821540","https://openalex.org/W2472896174","https://openalex.org/W3034687286","https://openalex.org/W4214551044","https://openalex.org/W4300605027","https://openalex.org/W4376095866"],"related_works":["https://openalex.org/W2037980547","https://openalex.org/W2349037035","https://openalex.org/W4401439486","https://openalex.org/W2069042623","https://openalex.org/W4388803337","https://openalex.org/W2053732743","https://openalex.org/W2364573062","https://openalex.org/W2283369947","https://openalex.org/W2001133468","https://openalex.org/W2084914593"],"abstract_inverted_index":{"OBJECTIVES:":[0],"This":[1],"study":[2],"examines":[3],"the":[4,49,158],"presence":[5],"of":[6,31,57,74,86,102,116,127,131],"Epstein-Barr":[7],"virus":[8],"(EBV)":[9],"in":[10,88,96,106,161],"nasopharyngeal":[11,89,110],"carcinoma":[12],"(NPC)":[13],"by":[14,61,104],"using":[15],"polymerase":[16],"chain":[17],"reaction":[18],"(PCR).":[19],"STUDY":[20],"DESIGN:":[21],"Eighty-six":[22],"postnasal":[23],"biopsy":[24,90,111],"samples":[25,30,91,115],"and":[26,51,54,82,112,124,141,156,168,171],"71":[27],"fine-needle":[28,97,113,144],"aspirate":[29,98,114,145],"neck":[32,117],"masses":[33,118],"were":[34,39,59,65,92],"obtained":[35,108],"from":[36,48,109],"patients":[37],"who":[38],"clinically":[40],"suspect":[41],"for":[42,153],"NPC.":[43,129],"Genomic":[44],"DNA":[45],"was":[46],"extracted":[47],"samples,":[50],"EBNA1,":[52],"EBNA2,":[53],"LMP":[55,83],"genes":[56,85,133],"EBV":[58,87,103,132],"detected":[60],"PCR.":[62],"PCR":[63,75,105,148],"results":[64],"compared":[66],"with":[67,137],"NPC":[68,155],"histopathology":[69],"findings.":[70],"RESULTS:":[71],"The":[72],"sensitivity":[73],"to":[76,143],"detect":[77],"EBNA1":[78],"(97.14%),":[79],"EBNA2":[80],"(88.57%),":[81],"(91.43%)":[84],"higher":[93],"than":[94],"those":[95],"samples.":[99],"CONCLUSION:":[100],"Detection":[101,130],"tissue":[107],"is":[119,134,149],"a":[120],"relatively":[121],"inexpensive,":[122],"reliable,":[123],"accurate":[125],"method":[126],"diagnosing":[128],"on":[135],"par":[136],"histopathological":[138],"examination":[139],"(HPE)":[140],"superior":[142],"cytology.":[146],"SIGNIFICANCE:":[147],"an":[150],"ideal":[151],"tool":[152],"suggesting":[154],"guiding":[157],"diagnostic":[159],"workup":[160],"occult":[162],"primary":[163],"tumors,":[164],"facilitating":[165],"earlier":[166],"diagnosis":[167],"reducing":[169],"morbidity":[170],"mortality.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
