{"id":"https://openalex.org/W2095774113","doi":"https://doi.org/10.1016/s0022-5347(01)66693-x","title":"The Relationship of Local Control to Distant Metastasis in Muscle Invasive Bladder Cancer","display_name":"The Relationship of Local Control to Distant Metastasis in Muscle Invasive Bladder Cancer","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2095774113","doi":"https://doi.org/10.1016/s0022-5347(01)66693-x","mag":"2095774113","pmid":"https://pubmed.ncbi.nlm.nih.gov/7500458"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(01)66693-x","doi":"https://doi.org/10.1016/s0022-5347(01)66693-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(01)66693-x","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063389942","display_name":"Alan S Pollack","orcid":"https://orcid.org/0000-0002-1801-2865","observed_orcids":["https://orcid.org/0000-0002-1801-2865"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Pollack","raw_affiliation_strings":["Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054759359","display_name":"Gunar K. Zagars","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunar K. Zagars","raw_affiliation_strings":["Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037234210","display_name":"Christopher J. Cole","orcid":"https://orcid.org/0009-0002-4063-4553","observed_orcids":["https://orcid.org/0009-0002-4063-4553"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Cole","raw_affiliation_strings":["Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002737792","display_name":"Colin P. Dinney","orcid":"https://orcid.org/0000-0002-8969-711X","observed_orcids":["https://orcid.org/0000-0002-8969-711X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin P.N. Dinney","raw_affiliation_strings":["Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045893266","display_name":"David A. Swanson","orcid":"https://orcid.org/0000-0003-4284-9478","observed_orcids":["https://orcid.org/0000-0003-4284-9478"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Swanson","raw_affiliation_strings":["Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037985318","display_name":"H. Barton Grossman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Barton Grossman","raw_affiliation_strings":["Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiotherapy and Urology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":6.7706,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.9711303,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"154","issue":"6","first_page":"2059","last_page":"2063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-invasive-bladder-cancer","display_name":"muscle-invasive bladder cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/local-failure","display_name":"local failure","score":0.7269999980926514},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/radical-cystectomy","display_name":"radical cystectomy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.7609999775886536},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pathological-stage","display_name":"pathological stage","score":0.8159999847412109},{"id":"https://openalex.org/keywords/lymph-node-involvement","display_name":"lymph node involvement","score":0.9800000190734863},{"id":"https://openalex.org/keywords/preoperative-radiotherapy","display_name":"preoperative radiotherapy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8658643364906311},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.7605252265930176},{"id":"https://openalex.org/C2780596892","wikidata":"https://www.wikidata.org/wiki/Q21493218","display_name":"Grossman","level":2,"score":0.7212986350059509},{"id":"https://openalex.org/C2775910329","wikidata":"https://www.wikidata.org/wiki/Q245995","display_name":"Cystectomy","level":4,"score":0.684086799621582},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6585056185722351},{"id":"https://openalex.org/C3019926457","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Distant metastasis","level":4,"score":0.6582827568054199},{"id":"https://openalex.org/C2778065480","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Transitional cell carcinoma","level":4,"score":0.48461851477622986},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4158865809440613},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41575199365615845},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3264867663383484},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.32296037673950195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25626975297927856},{"id":"https://openalex.org/C165556158","wikidata":"https://www.wikidata.org/wiki/Q83937","display_name":"Keynesian economics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000206","descriptor_name":"Actuarial Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-5347(01)66693-x","doi":"https://doi.org/10.1016/s0022-5347(01)66693-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(01)66693-x","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"doi:10.1097/00005392-199512000-00026","doi":"https://doi.org/10.1097/00005392-199512000-00026","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005392-199512000-00026","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Urology","raw_type":"journal-article"},{"id":"pmid:7500458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7500458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9994999766349792}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2178416488","display_name":"Extension of Radiotherapy Research","funder_award_id":"P01CA006294","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8050018355","display_name":null,"funder_award_id":"CA 16692","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G898094265","display_name":null,"funder_award_id":"CA06294","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W23441172","https://openalex.org/W1426844501","https://openalex.org/W1594148294","https://openalex.org/W1970144403","https://openalex.org/W1976898191","https://openalex.org/W1987466655","https://openalex.org/W1995220528","https://openalex.org/W2036880254","https://openalex.org/W2037993133","https://openalex.org/W2062720900","https://openalex.org/W2094331414","https://openalex.org/W2113251111","https://openalex.org/W2136883754","https://openalex.org/W2148204645","https://openalex.org/W2156003808","https://openalex.org/W2158285353","https://openalex.org/W2408314732","https://openalex.org/W2414152456","https://openalex.org/W2414648461","https://openalex.org/W2494864738","https://openalex.org/W2504616689","https://openalex.org/W2797482815","https://openalex.org/W2797597138","https://openalex.org/W4245152549","https://openalex.org/W4300110167","https://openalex.org/W6724672376","https://openalex.org/W6760214620"],"related_works":["https://openalex.org/W310447720","https://openalex.org/W2142981756","https://openalex.org/W2132238059","https://openalex.org/W1987466655","https://openalex.org/W4240798696","https://openalex.org/W2943065861","https://openalex.org/W2107360160","https://openalex.org/W2030032573","https://openalex.org/W2076641085","https://openalex.org/W2033000290"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"examined":[2],"the":[3,53,152,175,195,226,240,285],"relationship":[4,102,149],"of":[5,52,57,114,162,169,174,178,197,261,269,287],"local":[6,81,104,117,130,140,232,246,257],"failure":[7,105,141,233,247,270],"to":[8,47,135,206,238,255,293],"distant":[9,85,107,110,124,210,223,251],"metastasis":[10,86,108,111,125,211,224],"in":[11,112,172,301],"patients":[12,26,58,276],"with":[13,28,31,109,116,129,139,209,220,250,277],"muscle":[14],"invasive":[15],"bladder":[16],"cancer.":[17],"MATERIALS":[18],"AND":[19],"METHODS:":[20],"This":[21,148],"retrospective":[22],"review":[23],"included":[24],"240":[25],"treated":[27],"radical":[29,296],"cystectomy":[30,164],"or":[32],"without":[33],"multiagent":[34],"chemotherapy":[35,294],"at":[36,266],"our":[37],"institution":[38],"between":[39,103],"1984":[40],"and":[41,69,87,94,106,158,202,234,295],"1990":[42],"for":[43,127,137,264],"clinical":[44,60,188],"stage":[45,61,157,201],"T2":[46],"T4":[48],"transitional":[49],"cell":[50],"carcinoma":[51],"bladder.":[54],"The":[55,78,119,167],"distribution":[56],"by":[59,156,271],"was":[62,74,98,132,154,182],"89":[63],"T2,":[64],"77":[65],"T3a,":[66],"51":[67],"T3b":[68],"23":[70],"T4.":[71],"Median":[72],"followup":[73],"55":[75],"months.":[76],"RESULTS:":[77],"actuarial":[79,120],"5-year":[80,121],"control,":[82],"freedom":[83,122,221],"from":[84,123,222],"overall":[88],"survival":[89],"rates":[90],"were":[91,165],"80%,":[92],"68%":[93],"52%,":[95],"respectively.":[96],"There":[97],"a":[99],"profoundly":[100],"significant":[101,242],"56%":[113],"those":[115,128,138,265],"failure.":[118],"rate":[126],"control":[131,258],"77%":[133],"compared":[134],"29%":[136],"(p":[142],"<":[143],"0.0001,":[144],"log":[145],"rank":[146],"test).":[147],"held":[150],"when":[151,159],"group":[153],"subdivided":[155],"only":[160,241],"cases":[161],"complete":[163],"analyzed.":[166],"significance":[168],"this":[170,272,302],"finding":[171],"light":[173],"possible":[176],"contribution":[177],"potential":[179],"prognostic":[180],"factors":[181],"examined.":[183],"Univariate":[184],"analyses":[185,214],"revealed":[186,229],"late":[187,199],"stage,":[189,231],"abnormal":[190],"pretreatment":[191],"serum":[192],"creatinine":[193],"levels,":[194],"administration":[196],"chemotherapy,":[198],"pathological":[200,230],"lymph":[203,235],"node":[204,236],"involvement":[205,237],"correlate":[207],"significantly":[208],"rates.":[212],"Multivariate":[213],"using":[215],"Cox":[216],"proportional":[217],"hazards":[218],"models":[219],"as":[225,284,290],"end":[227],"point":[228],"be":[239,260,299],"covariates.":[243],"CONCLUSIONS:":[244],"Since":[245],"highly":[248],"correlated":[249],"failure,":[252],"treatment":[253,281],"planning":[254],"optimize":[256],"should":[259,298],"foremost":[262],"concern":[263],"high":[267,303],"risk":[268,304],"mode":[273],"(for":[274],"example":[275],"T3b/4":[278],"disease).":[279],"New":[280],"strategies,":[282],"such":[283],"use":[286],"preoperative":[288],"radiotherapy":[289],"an":[291],"adjunct":[292],"surgery,":[297],"considered":[300],"population.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}