{"id":"https://openalex.org/W2095754263","doi":"https://doi.org/10.1016/j.gene.2015.10.061","title":"Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro","display_name":"Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro","publication_year":2015,"publication_date":"2015-10-27","ids":{"openalex":"https://openalex.org/W2095754263","doi":"https://doi.org/10.1016/j.gene.2015.10.061","mag":"2095754263","pmid":"https://pubmed.ncbi.nlm.nih.gov/26516023"},"language":"en","primary_location":{"id":"doi:10.1016/j.gene.2015.10.061","doi":"https://doi.org/10.1016/j.gene.2015.10.061","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gene.2015.10.061","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013684179","display_name":"Umut Fahrio\u011flu","orcid":"https://orcid.org/0000-0002-7933-2395","observed_orcids":["https://orcid.org/0000-0002-7933-2395"]},"institutions":[{"id":"https://openalex.org/I69050122","display_name":"Near East University","ror":"https://ror.org/02x8svs93","country_code":"CY","type":"education","lineage":["https://openalex.org/I69050122"]}],"countries":["CY"],"is_corresponding":true,"raw_author_name":"Umut Fahrio\u011flu","raw_affiliation_strings":["Near East University, Faculty of Medicine, Department of Medical Biology, Nicosia, North Cyprus. Electronic address: umutfahrioglu@gmail.com","Near East University Faculty of Medicine, Department of Medical Biology, Nicosia, North Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Near East University, Faculty of Medicine, Department of Medical Biology, Nicosia, North Cyprus. Electronic address: umutfahrioglu@gmail.com","institution_ids":["https://openalex.org/I69050122"]},{"raw_affiliation_string":"Near East University Faculty of Medicine, Department of Medical Biology, Nicosia, North Cyprus","institution_ids":["https://openalex.org/I69050122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083911390","display_name":"Yavuz Dodurga","orcid":"https://orcid.org/0000-0002-4936-5954","observed_orcids":["https://orcid.org/0000-0002-4936-5954"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yavuz Dodurga","raw_affiliation_strings":["Pamukkale University, Faculty of Medicine, Department of Medical Biology and Genetics, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pamukkale University, Faculty of Medicine, Department of Medical Biology and Genetics, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025297093","display_name":"Levent Elmas","orcid":"https://orcid.org/0000-0002-6865-6466","observed_orcids":["https://orcid.org/0000-0002-6865-6466"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Levent Elmas","raw_affiliation_strings":["Pamukkale University, Faculty of Medicine, Department of Medical Biology and Genetics, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pamukkale University, Faculty of Medicine, Department of Medical Biology and Genetics, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077434452","display_name":"M\u00fccahit Se\u00e7me","orcid":"https://orcid.org/0000-0002-2084-760X","observed_orcids":["https://orcid.org/0000-0002-2084-760X"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M\u00fccahit Se\u00e7me","raw_affiliation_strings":["Pamukkale University, Faculty of Medicine, Department of Medical Biology and Genetics, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pamukkale University, Faculty of Medicine, Department of Medical Biology and Genetics, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013684179"],"corresponding_institution_ids":["https://openalex.org/I69050122"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":3.026,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.93390619,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"576","issue":"1","first_page":"476","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.04270000010728836,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferulic-acid","display_name":"ferulic acid","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mia-paca-2-cells","display_name":"MIA PaCa-2 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.746999979019165},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9200000166893005},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7450000047683716},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7070000171661377},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7860000133514404},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.906000018119812},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.75},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.8180000185966492},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.7647708654403687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.762341320514679},{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.6040990352630615},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5410605072975159},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5207962393760681},{"id":"https://openalex.org/C199649820","wikidata":"https://www.wikidata.org/wiki/Q14911762","display_name":"Cyclin-dependent kinase 6","level":5,"score":0.5168726444244385},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4788796305656433},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45390406250953674},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4451702833175659},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.42922914028167725},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4248703122138977},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3564613461494446},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25830477476119995},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.23194974660873413},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.21595776081085205},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15994295477867126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003373","descriptor_name":"Coumaric Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.gene.2015.10.061","doi":"https://doi.org/10.1016/j.gene.2015.10.061","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gene.2015.10.061","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},{"id":"pmid:26516023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26516023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W343850836","https://openalex.org/W602568009","https://openalex.org/W765788331","https://openalex.org/W1875592451","https://openalex.org/W1900499697","https://openalex.org/W1966021810","https://openalex.org/W1973268287","https://openalex.org/W1978763455","https://openalex.org/W1979995768","https://openalex.org/W1992929356","https://openalex.org/W1993531644","https://openalex.org/W2009007206","https://openalex.org/W2017882519","https://openalex.org/W2020166858","https://openalex.org/W2025508527","https://openalex.org/W2028112576","https://openalex.org/W2031985909","https://openalex.org/W2032337032","https://openalex.org/W2048721919","https://openalex.org/W2049895103","https://openalex.org/W2054786345","https://openalex.org/W2056780562","https://openalex.org/W2059151656","https://openalex.org/W2064072209","https://openalex.org/W2066262556","https://openalex.org/W2082510180","https://openalex.org/W2089655089","https://openalex.org/W2092330441","https://openalex.org/W2094139685","https://openalex.org/W2094788276","https://openalex.org/W2098084949","https://openalex.org/W2111220012","https://openalex.org/W2123811677","https://openalex.org/W2127822816","https://openalex.org/W2133382697","https://openalex.org/W2318853017","https://openalex.org/W4213212834","https://openalex.org/W6611743325","https://openalex.org/W6641941869"],"related_works":["https://openalex.org/W765788331","https://openalex.org/W2054786345","https://openalex.org/W2069246365","https://openalex.org/W2883215714","https://openalex.org/W1269790909","https://openalex.org/W1847882163","https://openalex.org/W2992270776","https://openalex.org/W4401258767","https://openalex.org/W2064602035","https://openalex.org/W3000613825"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}