{"id":"https://openalex.org/W2095640498","doi":"https://doi.org/10.1177/1078155211399163","title":"Differentiation syndrome in patients with acute promyelocytic leukemia","display_name":"Differentiation syndrome in patients with acute promyelocytic leukemia","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W2095640498","doi":"https://doi.org/10.1177/1078155211399163","mag":"2095640498","pmid":"https://pubmed.ncbi.nlm.nih.gov/21364078"},"language":"en","primary_location":{"id":"doi:10.1177/1078155211399163","doi":"https://doi.org/10.1177/1078155211399163","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1078155211399163","pdf_url":null,"source":{"id":"https://openalex.org/S66425452","display_name":"Journal of Oncology Pharmacy Practice","issn_l":"1078-1552","issn":["1078-1552","1477-092X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology Pharmacy Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013187820","display_name":"Jane Elizabeth Rogers","orcid":"https://orcid.org/0000-0002-7275-7008","observed_orcids":["https://orcid.org/0000-0002-7275-7008"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane E Rogers","raw_affiliation_strings":["UT MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088661109","display_name":"Daisy Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daisy Yang","raw_affiliation_strings":["UT MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088661109"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.2837,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.77132925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"109","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/differentiation-syndrome","display_name":"differentiation syndrome","score":0.9890000224113464},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.996999979019165},{"id":"https://openalex.org/keywords/corticosteroid-prophylaxis","display_name":"corticosteroid prophylaxis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hyperleukocytosis","display_name":"hyperleukocytosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/cardiorespiratory-compromise","display_name":"cardiorespiratory compromise","score":0.9110000133514404},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6269999742507935},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.8389999866485596},{"id":"https://openalex.org/keywords/treatment-related-complications","display_name":"treatment complications","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.9227890968322754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9157333374023438},{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.8844960927963257},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5082494616508484},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4751988649368286},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.4604495167732239},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43809840083122253},{"id":"https://openalex.org/C2777466982","wikidata":"https://www.wikidata.org/wiki/Q5227287","display_name":"Data extraction","level":3,"score":0.42526954412460327},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4119282364845276},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.41042348742485046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.394064337015152},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36274147033691406},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.08033233880996704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077237","descriptor_name":"Arsenic Trioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1177/1078155211399163","doi":"https://doi.org/10.1177/1078155211399163","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1078155211399163","pdf_url":null,"source":{"id":"https://openalex.org/S66425452","display_name":"Journal of Oncology Pharmacy Practice","issn_l":"1078-1552","issn":["1078-1552","1477-092X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology Pharmacy Practice","raw_type":"journal-article"},{"id":"pmid:21364078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21364078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.829.9907","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.829.9907","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://opp.sagepub.com/content/early/2011/03/06/1078155211399163.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.831.8354","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.831.8354","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://opp.sagepub.com/content/18/1/109.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W127746953","https://openalex.org/W570370693","https://openalex.org/W1977627834","https://openalex.org/W1982745688","https://openalex.org/W1992842669","https://openalex.org/W2012308368","https://openalex.org/W2023546573","https://openalex.org/W2040604171","https://openalex.org/W2043306142","https://openalex.org/W2047870782","https://openalex.org/W2055722425","https://openalex.org/W2058914060","https://openalex.org/W2064671776","https://openalex.org/W2072832316","https://openalex.org/W2101301060","https://openalex.org/W2111279921","https://openalex.org/W2123222392","https://openalex.org/W2133523831","https://openalex.org/W2137892174","https://openalex.org/W2138630072","https://openalex.org/W2141587832","https://openalex.org/W2142280518","https://openalex.org/W2152113001","https://openalex.org/W2155233750","https://openalex.org/W2159456353","https://openalex.org/W2334200141"],"related_works":["https://openalex.org/W7095176510","https://openalex.org/W7099140664","https://openalex.org/W2968563688","https://openalex.org/W2130937042","https://openalex.org/W1982745688","https://openalex.org/W2034259042","https://openalex.org/W2081798900","https://openalex.org/W2039146967","https://openalex.org/W7204249933","https://openalex.org/W2603345871"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"review":[2],"the":[3,29,52,80,89,148],"pathophysiology,":[4],"risk":[5],"factors,":[6],"and":[7,40,64,84,94,101,114,139],"management":[8,149],"of":[9,91,96,142,150],"differentiation":[10,165],"syndrome":[11,98],"(DS)":[12],"associated":[13],"with":[14,79,117,122,158],"acute":[15],"promyelocytic":[16],"leukemia":[17],"(APL).":[18],"DATA":[19,57],"SOURCE:":[20],"A":[21],"MEDLINE":[22,53],"search":[23,54],"was":[24],"conducted":[25],"(1977-November":[26],"2010)":[27],"using":[28],"terms":[30],"APL,":[31],"DS,":[32],"all-trans":[33],"retinoic":[34,37],"acid":[35,38],"(ATRA),":[36],"syndrome,":[39],"arsenic":[41],"trioxide":[42],"(ATO).":[43],"METHODS":[44],"OF":[45],"STUDY":[46],"SELECTION:":[47],"English":[48],"articles":[49],"identified":[50],"from":[51,133,164],"were":[55],"evaluated.":[56],"EXTRACTION":[58],"AND":[59],"SYNTHESIS:":[60],"With":[61],"ATRA,":[62],"ATO,":[63,85],"chemotherapy,":[65],"a":[66,123],"complete":[67],"remission":[68],"is":[69,110],"achievable":[70],"for":[71],"most":[72],"newly":[73],"diagnosed":[74],"APL":[75],"patients.":[76],"However,":[77],"treatment":[78],"differentiating":[81],"agents,":[82],"ATRA":[83],"can":[86,106,162],"lead":[87],"to":[88,155],"development":[90],"DS.":[92,151],"Signs":[93],"symptoms":[95],"this":[97,159],"include":[99],"hyperleukocytosis":[100],"cardiorespiratory":[102],"compromise.":[103],"Severe":[104],"complications":[105],"develop,":[107],"if":[108],"DS":[109],"not":[111],"recognized":[112],"early":[113],"treated":[115],"promptly":[116],"corticosteroids.":[118],"In":[119],"addition,":[120],"patients":[121],"high":[124],"white":[125],"blood":[126],"cell":[127],"count":[128],"at":[129],"diagnosis":[130],"may":[131],"benefit":[132],"prophylactic":[134],"steroids.":[135],"CONCLUSIONS:":[136],"Early":[137],"recognition":[138],"prompt":[140],"initiation":[141],"corticosteroids":[143],"are":[144],"key":[145],"factors":[146],"in":[147],"Healthcare":[152],"professionals":[153],"need":[154],"be":[156],"familiar":[157],"complication":[160],"which":[161],"arise":[163],"agents.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
