{"id":"https://openalex.org/W2095616215","doi":"https://doi.org/10.1158/1055-9965.epi-14-0053","title":"Circulating 25-hydroxyvitamin D Levels and Prognosis among Cancer Patients: A Systematic Review","display_name":"Circulating 25-hydroxyvitamin D Levels and Prognosis among Cancer Patients: A Systematic Review","publication_year":2014,"publication_date":"2014-04-02","ids":{"openalex":"https://openalex.org/W2095616215","doi":"https://doi.org/10.1158/1055-9965.epi-14-0053","mag":"2095616215","pmid":"https://pubmed.ncbi.nlm.nih.gov/24692501"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-14-0053","doi":"https://doi.org/10.1158/1055-9965.epi-14-0053","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-14-0053","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090275616","display_name":"Adetunji T. Toriola","orcid":"https://orcid.org/0000-0003-1079-2606","observed_orcids":["https://orcid.org/0000-0003-1079-2606"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4390039355","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299725459","https://openalex.org/I1328499231","https://openalex.org/I4390039355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adetunji T. Toriola","raw_affiliation_strings":["Authors' Affiliation: Division of Public Health Sciences, Department of Surgery, and Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Division of Public Health Sciences, Department of Surgery, and Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4390039355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020975984","display_name":"Nhi Thi Hong Nguyen","orcid":"https://orcid.org/0000-0001-7195-6171","observed_orcids":["https://orcid.org/0000-0001-7195-6171"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4390039355","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299725459","https://openalex.org/I1328499231","https://openalex.org/I4390039355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nhi Nguyen","raw_affiliation_strings":["Authors' Affiliation: Division of Public Health Sciences, Department of Surgery, and Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Division of Public Health Sciences, Department of Surgery, and Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4390039355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019744795","display_name":"Kristen M. Scheitler","orcid":"https://orcid.org/0000-0002-9082-9650","observed_orcids":["https://orcid.org/0000-0002-9082-9650"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4390039355","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299725459","https://openalex.org/I1328499231","https://openalex.org/I4390039355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen Scheitler-Ring","raw_affiliation_strings":["Authors' Affiliation: Division of Public Health Sciences, Department of Surgery, and Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Division of Public Health Sciences, Department of Surgery, and Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4390039355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031201037","display_name":"Graham A. Colditz","orcid":"https://orcid.org/0000-0002-7307-0291","observed_orcids":["https://orcid.org/0000-0002-7307-0291"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4390039355","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299725459","https://openalex.org/I1328499231","https://openalex.org/I4390039355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graham A. Colditz","raw_affiliation_strings":["Authors' Affiliation: Division of Public Health Sciences, Department of Surgery, and Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Division of Public Health Sciences, Department of Surgery, and Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4390039355"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8882,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.64856512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"6","first_page":"917","last_page":"933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cancer-prognosis","display_name":"cancer prognosis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5040000081062317},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.9750000238418579},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cancer-survivors","display_name":"cancer survivors","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.865898847579956},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.780002236366272},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7465845346450806},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.6584363579750061},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6495349407196045},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6025527119636536},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5799327492713928},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5188897252082825},{"id":"https://openalex.org/C83867959","wikidata":"https://www.wikidata.org/wiki/Q371467","display_name":"Scopus","level":3,"score":0.4880608320236206},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.44244006276130676},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.39428386092185974},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1055-9965.epi-14-0053","doi":"https://doi.org/10.1158/1055-9965.epi-14-0053","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-14-0053","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers & Prevention","raw_type":"journal-article"},{"id":"pmid:24692501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24692501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1538974297","https://openalex.org/W1604869223","https://openalex.org/W1936869709","https://openalex.org/W1964611803","https://openalex.org/W1965256036","https://openalex.org/W1966551048","https://openalex.org/W1985756413","https://openalex.org/W1986189483","https://openalex.org/W1988124413","https://openalex.org/W1997028893","https://openalex.org/W2000743440","https://openalex.org/W2005879837","https://openalex.org/W2007871042","https://openalex.org/W2014628140","https://openalex.org/W2019962813","https://openalex.org/W2022729502","https://openalex.org/W2025641935","https://openalex.org/W2026644677","https://openalex.org/W2028914452","https://openalex.org/W2029795537","https://openalex.org/W2043054321","https://openalex.org/W2047539755","https://openalex.org/W2058892986","https://openalex.org/W2063804109","https://openalex.org/W2064512935","https://openalex.org/W2070337339","https://openalex.org/W2081896262","https://openalex.org/W2090239878","https://openalex.org/W2093206323","https://openalex.org/W2095209405","https://openalex.org/W2096065464","https://openalex.org/W2096403161","https://openalex.org/W2097620787","https://openalex.org/W2098256087","https://openalex.org/W2099665543","https://openalex.org/W2106659212","https://openalex.org/W2108631382","https://openalex.org/W2110745206","https://openalex.org/W2118540989","https://openalex.org/W2118582534","https://openalex.org/W2122003737","https://openalex.org/W2124070987","https://openalex.org/W2126679194","https://openalex.org/W2126975848","https://openalex.org/W2137235604","https://openalex.org/W2140244530","https://openalex.org/W2142544310","https://openalex.org/W2145313480","https://openalex.org/W2151751946","https://openalex.org/W2154749163","https://openalex.org/W2160381920","https://openalex.org/W2162459349","https://openalex.org/W2162479033","https://openalex.org/W2163577786","https://openalex.org/W2166131704","https://openalex.org/W2168306115","https://openalex.org/W2169111212","https://openalex.org/W2170390325","https://openalex.org/W2171345315"],"related_works":["https://openalex.org/W2068035703","https://openalex.org/W2621324963","https://openalex.org/W2490042748","https://openalex.org/W2906828084","https://openalex.org/W2885502805","https://openalex.org/W4242518812","https://openalex.org/W7095582683","https://openalex.org/W2409796778","https://openalex.org/W2921885895","https://openalex.org/W1980154856"],"abstract_inverted_index":{"Circulating":[0],"25-hydroxyvitamin":[1],"D":[2,45,176],"(25-OHD)":[3],"is":[4,23,65,150],"associated":[5,137],"with":[6,17,21,49,63,123,127,138,143,158,181],"a":[7,69,151],"reduction":[8],"in":[9,35,59,75,141,160,177],"risk":[10],"of":[11,28,32,43,53,56,72,120,153,174],"some":[12],"cancers,":[13],"but":[14,148],"its":[15,156],"association":[16,157],"prognosis":[18,60,124,140,159,178],"among":[19,47,61,125,179],"patients":[20,48,62,126,142,180],"cancer":[22,33,64],"poorly":[24],"understood.":[25],"In":[26],"view":[27],"the":[29,36,40,54,76,89,109,118,166,172],"increasing":[30],"number":[31],"survivors":[34],"United":[37],"States":[38],"and":[39,83,101,145],"high":[41],"prevalence":[42],"vitamin":[44,175],"deficiency":[46],"cancer,":[50,147],"an":[51],"evaluation":[52],"role":[55,173],"circulating":[57,121,132],"25-OHD":[58,122,133],"essential.":[66],"We":[67],"conducted":[68],"systematic":[70],"review":[71,164],"studies":[73,115,170],"published":[74],"following":[77,90],"databases-PubMed,":[78],"OvidSP,":[79],"BioMed":[80],"Central,":[81],"EMBASE,":[82],"Scopus":[84],"till":[85],"September":[86],"2013":[87],"using":[88],"search":[91,104],"terms:":[92],"\"vitamin":[93],"D,\"":[94,96],"\"25-hydroxyvitamin":[95],"\"calcidiol,\"":[97],"\"cancer,\"":[98],"\"survival,\"":[99],"\"mortality,\"":[100],"\"prognosis.\"":[102],"Our":[103],"yielded":[105],"1,397":[106,110],"articles.":[107],"From":[108],"articles,":[111],"we":[112],"identified":[113],"26":[114],"that":[116,131],"evaluated":[117],"associations":[119],"cancer.":[128,182],"Evidence":[129],"suggests":[130],"levels":[134],"may":[135],"be":[136],"better":[139],"breast":[144],"colorectal":[146],"there":[149],"paucity":[152],"information":[154],"on":[155],"other":[161],"cancers.":[162],"This":[163],"highlights":[165],"need":[167],"for":[168],"further":[169],"evaluating":[171],"Cancer":[183],"Epidemiol":[184],"Biomarkers":[185],"Prev;":[186],"23(6);":[187],"917-33.":[188],"\u00a92014":[189],"AACR.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}