{"id":"https://openalex.org/W2095570052","doi":"https://doi.org/10.1159/000228540","title":"Fibrogenic Growth Factors in Encapsulating Peritoneal Sclerosis","display_name":"Fibrogenic Growth Factors in Encapsulating Peritoneal Sclerosis","publication_year":2009,"publication_date":"2009-07-14","ids":{"openalex":"https://openalex.org/W2095570052","doi":"https://doi.org/10.1159/000228540","mag":"2095570052","pmid":"https://pubmed.ncbi.nlm.nih.gov/19602904"},"language":"en","primary_location":{"id":"doi:10.1159/000228540","doi":"https://doi.org/10.1159/000228540","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000228540","pdf_url":null,"source":{"id":"https://openalex.org/S4210230090","display_name":"Nephron Clinical Practice","issn_l":"1660-2110","issn":["1660-2110"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109754336","display_name":"N. Braun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802768257","display_name":"Robert Bosch Hospital","ror":"https://ror.org/034nkkr84","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802101015","https://openalex.org/I2802768257","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Braun","raw_affiliation_strings":["Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital, Stuttgart, Germany. niko.braun@rbk.de","Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital, Stuttgart, Germany. niko.braun@rbk.de","institution_ids":["https://openalex.org/I2802768257"]},{"raw_affiliation_string":"Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital,","institution_ids":["https://openalex.org/I2802768257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057301762","display_name":"Fabian R. Reimold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802768257","display_name":"Robert Bosch Hospital","ror":"https://ror.org/034nkkr84","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802101015","https://openalex.org/I2802768257","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Reimold","raw_affiliation_strings":["Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital,","institution_ids":["https://openalex.org/I2802768257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031292126","display_name":"Dagmar Biegger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Biegger","raw_affiliation_strings":["Margarete Fischer-Bosch Institute of Clinical Pharmacology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Margarete Fischer-Bosch Institute of Clinical Pharmacology,","institution_ids":["https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101830915","display_name":"P\u00e9ter Fritz","orcid":"https://orcid.org/0000-0001-7118-8811","observed_orcids":["https://orcid.org/0000-0001-7118-8811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Fritz","raw_affiliation_strings":["Division of Pathology, Department of Diagnostic Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, Department of Diagnostic Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008475816","display_name":"Martin Kimmel","orcid":"https://orcid.org/0000-0003-3368-1108","observed_orcids":["https://orcid.org/0000-0003-3368-1108"]},"institutions":[{"id":"https://openalex.org/I2802768257","display_name":"Robert Bosch Hospital","ror":"https://ror.org/034nkkr84","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802101015","https://openalex.org/I2802768257","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Kimmel","raw_affiliation_strings":["Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital,","institution_ids":["https://openalex.org/I2802768257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053036764","display_name":"Christoph Ulmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802768257","display_name":"Robert Bosch Hospital","ror":"https://ror.org/034nkkr84","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802101015","https://openalex.org/I2802768257","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Ulmer","raw_affiliation_strings":["Department of Surgery, Robert Bosch Hospital, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Robert Bosch Hospital, Stuttgart, Germany","institution_ids":["https://openalex.org/I2802768257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085553886","display_name":"Mark Dominik Alscher","orcid":"https://orcid.org/0000-0002-9658-1211","observed_orcids":["https://orcid.org/0000-0002-9658-1211"]},"institutions":[{"id":"https://openalex.org/I2802768257","display_name":"Robert Bosch Hospital","ror":"https://ror.org/034nkkr84","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802101015","https://openalex.org/I2802768257","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M.D. Alscher","raw_affiliation_strings":["Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital,","institution_ids":["https://openalex.org/I2802768257"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0362,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.90879804,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"113","issue":"2","first_page":"c88","last_page":"c95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12089","display_name":"Intestinal and Peritoneal Adhesions","score":0.3578999936580658,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12089","display_name":"Intestinal and Peritoneal Adhesions","score":0.3578999936580658,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.3280999958515167,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.08739999681711197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/encapsulating-peritoneal-sclerosis","display_name":"encapsulating peritoneal sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.722000002861023},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9610000252723694},{"id":"https://openalex.org/keywords/peritoneal-fibrosis","display_name":"peritoneal fibrosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/vasculopathy","display_name":"vasculopathy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8379999995231628},{"id":"https://openalex.org/keywords/peritoneal-dialysis","display_name":"peritoneal dialysis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/appendicitis","display_name":"appendicitis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/peritonitis","display_name":"peritonitis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/peritoneal-fibroblasts","display_name":"peritoneal fibroblasts","score":0.6470000147819519},{"id":"https://openalex.org/keywords/peritoneal-mesothelium","display_name":"peritoneal mesothelium","score":0.5649999976158142},{"id":"https://openalex.org/keywords/peritoneal-metastases","display_name":"peritoneal carcinomatosis","score":0.5239999890327454},{"id":"https://openalex.org/keywords/peritoneal-adhesions","display_name":"peritoneal adhesions","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8824872970581055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6476304531097412},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5935441255569458},{"id":"https://openalex.org/C2776001837","wikidata":"https://www.wikidata.org/wiki/Q9629","display_name":"Peritoneum","level":2,"score":0.5667497515678406},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5243542194366455},{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.5085817575454712},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4831914007663727},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4753035008907318},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43112826347351074},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4113942086696625},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.39692848920822144},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3147733509540558},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001064","descriptor_name":"Appendicitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001064","descriptor_name":"Appendicitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056627","descriptor_name":"Peritoneal Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D056627","descriptor_name":"Peritoneal Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000228540","doi":"https://doi.org/10.1159/000228540","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000228540","pdf_url":null,"source":{"id":"https://openalex.org/S4210230090","display_name":"Nephron Clinical Practice","issn_l":"1660-2110","issn":["1660-2110"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron Clinical Practice","raw_type":"journal-article"},{"id":"pmid:19602904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19602904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephron. Clinical practice","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W82187642","https://openalex.org/W89412302","https://openalex.org/W158281719","https://openalex.org/W1630458667","https://openalex.org/W1762724222","https://openalex.org/W1825286412","https://openalex.org/W1943090109","https://openalex.org/W1980866580","https://openalex.org/W1987271338","https://openalex.org/W2020968437","https://openalex.org/W2023719294","https://openalex.org/W2029457529","https://openalex.org/W2030704735","https://openalex.org/W2050586165","https://openalex.org/W2062594120","https://openalex.org/W2068061665","https://openalex.org/W2076707027","https://openalex.org/W2077129920","https://openalex.org/W2118254829","https://openalex.org/W2120492569","https://openalex.org/W2122776035","https://openalex.org/W2123963664","https://openalex.org/W2127217689","https://openalex.org/W2145709491","https://openalex.org/W2146755107","https://openalex.org/W2148161856","https://openalex.org/W2148616251","https://openalex.org/W2149405263","https://openalex.org/W2153262985","https://openalex.org/W2157769714","https://openalex.org/W2170749031","https://openalex.org/W2187501461","https://openalex.org/W2191071163","https://openalex.org/W3134431802"],"related_works":["https://openalex.org/W2023719294","https://openalex.org/W2288296061","https://openalex.org/W82187642","https://openalex.org/W2580745045","https://openalex.org/W1487368537","https://openalex.org/W2053332442","https://openalex.org/W2795831303","https://openalex.org/W2605241769","https://openalex.org/W2035114024","https://openalex.org/W2095534673"],"abstract_inverted_index":{"BACKGROUND:":[0],"Increased":[1],"local":[2],"levels":[3],"of":[4,13,59,64,73,95,214,241,254],"fibrogenic":[5],"growth":[6],"hormones":[7],"contribute":[8],"substantially":[9],"to":[10,262],"the":[11,57,62,71,145,212,249],"process":[12,240],"encapsulating":[14],"peritoneal":[15],"sclerosis":[16],"(EPS)":[17],"in":[18,116,153,164,187,248],"animal":[19],"models.":[20],"METHODS:":[21],"We":[22,55],"analyzed":[23],"probes":[24],"from":[25],"patients":[26],"with":[27,34,50,245,257],"normal":[28,35],"kidney":[29,36],"function":[30,37],"(n":[31,40,46,52],"=":[32,41,47,53,140],"10),":[33,42],"and":[38,49,61,66,83,107,134,148,178,203,230],"inflammation":[39,190],"on":[43],"PD":[44,103,130,174,188,199,226],"without":[45],"10)":[48],"EPS":[51,108,135,154,165,179,204,231,242],"9).":[54],"investigated":[56,70],"degree":[58],"fibrosis":[60,259],"number":[63],"vessels":[65,215,255],"vasculopathy.":[67],"Additionally,":[68],"we":[69,90],"expression":[72],"NFkappaB,":[74],"TGFbeta1,":[75],"TGFbeta1":[76],"receptor,":[77,80],"TGFbeta2,":[78],"TGFbeta2":[79],"FGF-BP,":[81],"CTGF":[82,118],"VEGF":[84,96,247],"by":[85],"immunohistochemistry.":[86],"RESULTS:":[87],"In":[88],"EPS,":[89],"found":[91],"an":[92,265],"exclusive":[93],"upregulation":[94],"(normal":[97,122,166,191,218],"0,":[98],"appendicitis":[99,126,170,195,222],"1.0":[100,175],"+/-":[101,105,110,124,128,132,137,168,172,176,181,193,197,201,206,220,224,228,233],"1.2,":[102],"1.7":[104],"1.8":[106,133],"5.7":[109],"4.4;":[111],"p":[112,139,183,208,235],"<":[113,184,209,236],"0.0001),":[114,210],"whereas":[115,211],"PD,":[117],"was":[119,160,243],"significantly":[120,161],"increased":[121,246],"6.0":[123],"2.8,":[125],"7.3":[127,136],"2.5,":[129],"10.0":[131],"2.1;":[138],"0.0059).":[141],"The":[142,239,251],"results":[143],"for":[144],"TGFbeta":[146],"system":[147],"NFkappaB":[149],"were":[150,157,216],"not":[151],"uniform,":[152],"no":[155],"increases":[156],"demonstrable.":[158],"Vasculopathy":[159],"more":[162],"pronounced":[163],"0.4":[167],"0.5,":[169],"0.2":[171],"0.3,":[173],"0.7":[177],"1.6":[180],"1.2;":[182],"0.0001)":[185],"than":[186],"or":[189],"30":[192],"16,":[194],"82":[196],"48,":[198],"1,936":[200],"952":[202],"2,613":[205],"1,209;":[207],"density":[213,253],"decreased":[217],"125":[219],"114,":[221],"817":[223],"347,":[225],"81":[227],"57":[229],"36":[232],"33;":[234],"0.0001).":[237],"CONCLUSIONS:":[238],"associated":[244],"peritoneum.":[250],"reduced":[252],"compared":[256],"marked":[258],"could":[260],"point":[261],"hypoxia":[263],"as":[264],"inducer.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
