{"id":"https://openalex.org/W2095569747","doi":"https://doi.org/10.1016/j.bmc.2009.03.015","title":"Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors\u2014A review of the triketone chemistry story from a Syngenta perspective","display_name":"Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors\u2014A review of the triketone chemistry story from a Syngenta perspective","publication_year":2009,"publication_date":"2009-03-15","ids":{"openalex":"https://openalex.org/W2095569747","doi":"https://doi.org/10.1016/j.bmc.2009.03.015","mag":"2095569747","pmid":"https://pubmed.ncbi.nlm.nih.gov/19349184"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmc.2009.03.015","doi":"https://doi.org/10.1016/j.bmc.2009.03.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2009.03.015","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089877162","display_name":"Renaud Beaudegnies","orcid":"https://orcid.org/0000-0001-7517-6420","observed_orcids":["https://orcid.org/0000-0001-7517-6420"]},"institutions":[{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Renaud Beaudegnies","raw_affiliation_strings":["Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland","institution_ids":["https://openalex.org/I89199228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062814850","display_name":"Andrew J. F. Edmunds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Andrew J.F. Edmunds","raw_affiliation_strings":["Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland","institution_ids":["https://openalex.org/I89199228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050682157","display_name":"Torquil E. M. Fraser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Torquil E.M. Fraser","raw_affiliation_strings":["Syngenta, Jealott\u2019s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta, Jealott\u2019s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067376368","display_name":"Roger G. Hall","orcid":"https://orcid.org/0000-0002-7568-5716","observed_orcids":["https://orcid.org/0000-0002-7568-5716"]},"institutions":[{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roger G. Hall","raw_affiliation_strings":["Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland","institution_ids":["https://openalex.org/I89199228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113654896","display_name":"Timothy R. Hawkes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy R. Hawkes","raw_affiliation_strings":["Syngenta, Jealott\u2019s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta, Jealott\u2019s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013553966","display_name":"Glynn Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Glynn Mitchell","raw_affiliation_strings":["Syngenta, Jealott\u2019s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta, Jealott\u2019s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112268842","display_name":"Juergen H. Schaetzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Juergen Schaetzer","raw_affiliation_strings":["Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland","institution_ids":["https://openalex.org/I89199228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004881340","display_name":"Sebastian V. Wendeborn","orcid":"https://orcid.org/0000-0002-2590-0115","observed_orcids":["https://orcid.org/0000-0002-2590-0115"]},"institutions":[{"id":"https://openalex.org/I89199228","display_name":"Syngenta (Switzerland)","ror":"https://ror.org/05fqg8t87","country_code":"CH","type":"company","lineage":["https://openalex.org/I89199228"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sebastian Wendeborn","raw_affiliation_strings":["Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection Muenchwilen AG, WST-820.1.15, Schaffhauserstrasse, CH-4332 Stein, Switzerland","institution_ids":["https://openalex.org/I89199228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065383656","display_name":"Jane Wibley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jane Wibley","raw_affiliation_strings":["Syngenta, Jealott\u2019s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta, Jealott\u2019s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom","institution_ids":["https://openalex.org/I4210087094"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013553966","https://openalex.org/A5062814850"],"corresponding_institution_ids":["https://openalex.org/I4210087094","https://openalex.org/I89199228"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.6598,"has_fulltext":false,"cited_by_count":230,"citation_normalized_percentile":{"value":0.49874687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"17","issue":"12","first_page":"4134","last_page":"4152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10774","display_name":"Weed Control and Herbicide Applications","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11180","display_name":"Pesticide and Herbicide Environmental Studies","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hppd-inhibitors","display_name":"HPPD inhibitors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/triketone-herbicides","display_name":"triketone herbicides","score":0.8849999904632568},{"id":"https://openalex.org/keywords/herbicide-development","display_name":"herbicide development","score":0.8199999928474426},{"id":"https://openalex.org/keywords/syngenta","display_name":"Syngenta","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9237411022186279},{"id":"https://openalex.org/C2776834422","wikidata":"https://www.wikidata.org/wiki/Q5279660","display_name":"Dioxygenase","level":3,"score":0.7224786281585693},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6254792213439941},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.46258923411369324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4224834740161896},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29804307222366333},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007659","descriptor_name":"Ketones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015111","descriptor_name":"4-Hydroxyphenylpyruvate Dioxygenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015111","descriptor_name":"4-Hydroxyphenylpyruvate Dioxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmc.2009.03.015","doi":"https://doi.org/10.1016/j.bmc.2009.03.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2009.03.015","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:19349184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19349184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W177994576","https://openalex.org/W1017367353","https://openalex.org/W1491173393","https://openalex.org/W1537083969","https://openalex.org/W1982959411","https://openalex.org/W1994080879","https://openalex.org/W2002062654","https://openalex.org/W2002369883","https://openalex.org/W2012797544","https://openalex.org/W2014777355","https://openalex.org/W2019798464","https://openalex.org/W2035804711","https://openalex.org/W2039978581","https://openalex.org/W2043704500","https://openalex.org/W2045299448","https://openalex.org/W2046997994","https://openalex.org/W2050115476","https://openalex.org/W2054157673","https://openalex.org/W2055894075","https://openalex.org/W2060394929","https://openalex.org/W2070314037","https://openalex.org/W2082230711","https://openalex.org/W2087398689","https://openalex.org/W2091259906","https://openalex.org/W2113390169","https://openalex.org/W2119325871","https://openalex.org/W2119700093","https://openalex.org/W2130322996","https://openalex.org/W2133648941","https://openalex.org/W2134671824","https://openalex.org/W2146574721","https://openalex.org/W2148095398","https://openalex.org/W2150337464","https://openalex.org/W2171643578","https://openalex.org/W2179254365","https://openalex.org/W2314717314","https://openalex.org/W2315899187","https://openalex.org/W2464770117","https://openalex.org/W2476601594","https://openalex.org/W2482700762","https://openalex.org/W2950541748","https://openalex.org/W2950571299"],"related_works":["https://openalex.org/W2414740201","https://openalex.org/W2760647541","https://openalex.org/W3161594854","https://openalex.org/W4380342465","https://openalex.org/W2580134572","https://openalex.org/W4405911672","https://openalex.org/W1531316831","https://openalex.org/W2321667681","https://openalex.org/W2980289225","https://openalex.org/W2352704593"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}