{"id":"https://openalex.org/W2095508697","doi":"https://doi.org/10.1016/j.cyto.2007.07.051","title":"46 A Class of Small Molecules that Inhibit TNF\u03b1-induced Survival and Death Pathways via Prevention of Interactions between TNF\u03b1RI, TRADD and RIP1","display_name":"46 A Class of Small Molecules that Inhibit TNF\u03b1-induced Survival and Death Pathways via Prevention of Interactions between TNF\u03b1RI, TRADD and RIP1","publication_year":2007,"publication_date":"2007-07-01","ids":{"openalex":"https://openalex.org/W2095508697","doi":"https://doi.org/10.1016/j.cyto.2007.07.051","mag":"2095508697"},"language":"en","primary_location":{"id":"doi:10.1016/j.cyto.2007.07.051","doi":"https://doi.org/10.1016/j.cyto.2007.07.051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cyto.2007.07.051","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031007480","display_name":"Tarikere L. Gururaja","orcid":"https://orcid.org/0000-0003-2684-2647","observed_orcids":["https://orcid.org/0000-0003-2684-2647"]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarikere L. Gururaja","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086614042","display_name":"Stephanie L. Yung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Yung","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060973697","display_name":"Rongxian Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rongxian Ding","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108827768","display_name":"Jianing Huang","orcid":"https://orcid.org/0009-0000-0324-1625","observed_orcids":["https://orcid.org/0009-0000-0324-1625","https://orcid.org/0009-0004-0258-4211"]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianing Huang","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024404939","display_name":"Xiulan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiulan Zhou","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103601436","display_name":"John R. McLaughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John McLaughlin","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080192004","display_name":"Sarkiz Daniel-Issakani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarkiz Daniel-Issakani","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018744873","display_name":"Rajinder Sing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajinder Sing","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073703590","display_name":"ROBIN D. G. COOPER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin D.G. Cooper","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113600276","display_name":"Donald G. Payan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald G. Payan","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063280084","display_name":"Esteban S. Masuda","orcid":"https://orcid.org/0000-0002-3175-2868","observed_orcids":["https://orcid.org/0000-0002-3175-2868"]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esteban Masuda","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039019546","display_name":"Taisei Kinoshita","orcid":"https://orcid.org/0000-0003-2688-4206","observed_orcids":["https://orcid.org/0000-0003-2688-4206"]},"institutions":[{"id":"https://openalex.org/I4210159901","display_name":"Rigel (United States)","ror":"https://ror.org/05j0yvv31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taisei Kinoshita","raw_affiliation_strings":["Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rigel Pharmaceuticals, Inc., South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I4210159901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210159901"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14964323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"1","first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tnf-receptor-1","display_name":"TNF receptor 1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tradd","display_name":"TRADD","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ripk1","display_name":"RIPK1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6859999895095825},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/small-molecules","display_name":"small molecules","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.9472064971923828},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.8525524139404297},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8126668930053711},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6024828553199768},{"id":"https://openalex.org/C2776472363","wikidata":"https://www.wikidata.org/wiki/Q14914379","display_name":"TRADD","level":5,"score":0.5810489058494568},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5571025609970093},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5488395094871521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4981663227081299},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47133588790893555},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4452120065689087},{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.4191990792751312},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3701455891132355},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35600948333740234},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.2772197127342224},{"id":"https://openalex.org/C2779004061","wikidata":"https://www.wikidata.org/wiki/Q5247322","display_name":"Death domain","level":4,"score":0.152790367603302},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1022556722164154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.054730772972106934},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.cyto.2007.07.051","doi":"https://doi.org/10.1016/j.cyto.2007.07.051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cyto.2007.07.051","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2072028737","https://openalex.org/W2058109980","https://openalex.org/W1983568583","https://openalex.org/W2590732849","https://openalex.org/W2141549675","https://openalex.org/W3210249046","https://openalex.org/W4318562430","https://openalex.org/W2890014969","https://openalex.org/W2074305443","https://openalex.org/W3211247659"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}