{"id":"https://openalex.org/W2095487228","doi":"https://doi.org/10.1016/s0196-9781(96)00249-5","title":"Enzyme Changes in Zymogen Granules and in Pancreatic Secretion Throughout Long-Term CCK Treatment","display_name":"Enzyme Changes in Zymogen Granules and in Pancreatic Secretion Throughout Long-Term CCK Treatment","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2095487228","doi":"https://doi.org/10.1016/s0196-9781(96)00249-5","mag":"2095487228","pmid":"https://pubmed.ncbi.nlm.nih.gov/9114459"},"language":"en","primary_location":{"id":"doi:10.1016/s0196-9781(96)00249-5","doi":"https://doi.org/10.1016/s0196-9781(96)00249-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0196-9781(96)00249-5","pdf_url":null,"source":{"id":"https://openalex.org/S120382301","display_name":"Peptides","issn_l":"0196-9781","issn":["0196-9781","1873-5169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peptides","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000824900","display_name":"Isabel DE DIOS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabel De Dios","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Salamanca, Spain","Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ana Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Rodriguez","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035827683","display_name":"Andr\u00e9s C. Garc\u00eda\u2010Montero","orcid":"https://orcid.org/0000-0003-4360-1386","observed_orcids":["https://orcid.org/0000-0003-4360-1386"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andres Garcia-Montero","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088409474","display_name":"Alberto \u00d3rf\u00e3o","orcid":"https://orcid.org/0000-0002-0007-7230","observed_orcids":["https://orcid.org/0000-0002-0007-7230"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Orfao","raw_affiliation_strings":["Flow Cytometry Service, University of Salamanca, 37007 Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flow Cytometry Service, University of Salamanca, 37007 Salamanca, Spain","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113556488","display_name":"Manuel Antonio Manso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Antonio Manso","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca Spain","institution_ids":["https://openalex.org/I184999862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184999862"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":1.4904,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81863005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"1","first_page":"101","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.08669999986886978,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cck-8","display_name":"CCK-8","score":0.8579999804496765},{"id":"https://openalex.org/keywords/zymogen-granules","display_name":"zymogen granules","score":0.953000009059906},{"id":"https://openalex.org/keywords/pancreatic-enzyme-secretion","display_name":"pancreatic enzyme secretion","score":0.7820000052452087},{"id":"https://openalex.org/keywords/trypsinogen","display_name":"trypsinogen","score":0.9210000038146973},{"id":"https://openalex.org/keywords/amylase","display_name":"amylase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pancreatic-hyperplasia","display_name":"pancreatic hyperplasia","score":0.7480000257492065},{"id":"https://openalex.org/keywords/pancreatic-acinar-cells","display_name":"pancreatic acinar cells","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2781286802","wikidata":"https://www.wikidata.org/wiki/Q421373","display_name":"Trypsinogen","level":4,"score":0.9394605159759521},{"id":"https://openalex.org/C2778775115","wikidata":"https://www.wikidata.org/wiki/Q245759","display_name":"Zymogen","level":3,"score":0.8226800560951233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7723522782325745},{"id":"https://openalex.org/C170835558","wikidata":"https://www.wikidata.org/wiki/Q17153","display_name":"Amylase","level":3,"score":0.7122063636779785},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7090350389480591},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.5781490802764893},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5397745966911316},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.529103696346283},{"id":"https://openalex.org/C2778677841","wikidata":"https://www.wikidata.org/wiki/Q422301","display_name":"Secretin","level":3,"score":0.5018875598907471},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4933559000492096},{"id":"https://openalex.org/C2777593968","wikidata":"https://www.wikidata.org/wiki/Q60315441","display_name":"Cholecystokinin","level":3,"score":0.46800675988197327},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.4667879343032837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3391087055206299},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33589696884155273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1950986385345459},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15685424208641052},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005779","descriptor_name":"Immunodiffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010189","descriptor_name":"Pancreatic Juice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010799","descriptor_name":"Phycoerythrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012844","descriptor_name":"Sincalide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014362","descriptor_name":"Trypsinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0196-9781(96)00249-5","doi":"https://doi.org/10.1016/s0196-9781(96)00249-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0196-9781(96)00249-5","pdf_url":null,"source":{"id":"https://openalex.org/S120382301","display_name":"Peptides","issn_l":"0196-9781","issn":["0196-9781","1873-5169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peptides","raw_type":"journal-article"},{"id":"pmid:9114459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9114459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peptides","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W151803331","https://openalex.org/W1278885947","https://openalex.org/W1525804184","https://openalex.org/W1785128704","https://openalex.org/W1854441215","https://openalex.org/W1906197854","https://openalex.org/W1965408883","https://openalex.org/W1966136061","https://openalex.org/W1971774789","https://openalex.org/W1974130352","https://openalex.org/W1979726132","https://openalex.org/W1981580419","https://openalex.org/W1990595542","https://openalex.org/W1990960012","https://openalex.org/W1995342025","https://openalex.org/W1999768175","https://openalex.org/W2003301005","https://openalex.org/W2004166313","https://openalex.org/W2009123972","https://openalex.org/W2009525110","https://openalex.org/W2015032365","https://openalex.org/W2015856660","https://openalex.org/W2017789861","https://openalex.org/W2018304119","https://openalex.org/W2033724612","https://openalex.org/W2052354891","https://openalex.org/W2055335988","https://openalex.org/W2057070381","https://openalex.org/W2057900932","https://openalex.org/W2061062060","https://openalex.org/W2065614618","https://openalex.org/W2084631863","https://openalex.org/W2094654835","https://openalex.org/W2103731896","https://openalex.org/W2128635872","https://openalex.org/W2133138476","https://openalex.org/W2146466663","https://openalex.org/W2273745026","https://openalex.org/W2328590405","https://openalex.org/W2398059704","https://openalex.org/W2399273858","https://openalex.org/W2401373286","https://openalex.org/W2411287195","https://openalex.org/W2426531650","https://openalex.org/W2464838263","https://openalex.org/W2884917768"],"related_works":["https://openalex.org/W2152194342","https://openalex.org/W1981998860","https://openalex.org/W4302859324","https://openalex.org/W2978298343","https://openalex.org/W337752682","https://openalex.org/W1994154542","https://openalex.org/W2028176381","https://openalex.org/W2014382164","https://openalex.org/W2004160079","https://openalex.org/W2098499216"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}