{"id":"https://openalex.org/W2095422977","doi":"https://doi.org/10.1074/jbc.m303743200","title":"Cytosolic Multiple Inositol Polyphosphate Phosphatase in the Regulation of Cytoplasmic Free Ca2+ Concentration","display_name":"Cytosolic Multiple Inositol Polyphosphate Phosphatase in the Regulation of Cytoplasmic Free Ca2+ Concentration","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W2095422977","doi":"https://doi.org/10.1074/jbc.m303743200","mag":"2095422977","pmid":"https://pubmed.ncbi.nlm.nih.gov/12963730"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m303743200","doi":"https://doi.org/10.1074/jbc.m303743200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m303743200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m303743200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103125763","display_name":"Jia Hui Yu","orcid":"https://orcid.org/0000-0002-1294-4856","observed_orcids":["https://orcid.org/0000-0002-1294-4856","https://orcid.org/0009-0000-4870-8540"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jia Yu","raw_affiliation_strings":["Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033200110","display_name":"Barbara Leibiger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Barbara Leibiger","raw_affiliation_strings":["Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004784857","display_name":"Shao-Nian Yang","orcid":"https://orcid.org/0000-0001-7470-7197","observed_orcids":["https://orcid.org/0000-0001-7470-7197"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Shao-Nian Yang","raw_affiliation_strings":["Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111971945","display_name":"J. Caffery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"James J. Caffery","raw_affiliation_strings":["Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","Inositide Signaling Section, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Inositide Signaling Section, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013107971","display_name":"Stephen B. Shears","orcid":"https://orcid.org/0000-0001-7309-8916","observed_orcids":["https://orcid.org/0000-0001-7309-8916"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Stephen B. Shears","raw_affiliation_strings":["Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","Inositide Signaling Section, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Inositide Signaling Section, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037533958","display_name":"Ingo B. Leibiger","orcid":"https://orcid.org/0000-0002-1766-8942","observed_orcids":["https://orcid.org/0000-0002-1766-8942"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ingo B. Leibiger","raw_affiliation_strings":["Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064964707","display_name":"Christopher J. Barker","orcid":"https://orcid.org/0000-0002-4962-766X","observed_orcids":["https://orcid.org/0000-0002-4962-766X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Christopher J. Barker","raw_affiliation_strings":["Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074543896","display_name":"Per\u2010Olof Berggren","orcid":"https://orcid.org/0000-0001-8991-413X","observed_orcids":["https://orcid.org/0000-0001-8991-413X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per-Olof Berggren","raw_affiliation_strings":["Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Rolf Luft Center for Diabetes Research, L3, Karolinska Institutet, Karolinska Hospital, Stockholm SE-171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5064964707"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.4331,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.78087649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"278","issue":"47","first_page":"46210","last_page":"46218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.48170000314712524,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.48170000314712524,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.3935999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate","display_name":"inositol 1,4,5-trisphosphate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.7639999985694885},{"id":"https://openalex.org/keywords/inositol-polyphosphates","display_name":"inositol polyphosphates","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2778038992","wikidata":"https://www.wikidata.org/wiki/Q420783","display_name":"Polyphosphate","level":3,"score":0.8829147815704346},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.8192143440246582},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.8063455820083618},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6591315269470215},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5972294211387634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5684558153152466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4470316767692566},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4394792914390564},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36221078038215637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2117994725704193},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.1755450963973999},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16111096739768982},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.16101467609405518},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.053039342164993286}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m303743200","doi":"https://doi.org/10.1074/jbc.m303743200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m303743200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12963730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12963730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m303743200","doi":"https://doi.org/10.1074/jbc.m303743200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m303743200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2048824832","display_name":null,"funder_award_id":"DK 58508","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8731564272","display_name":"BETA CELL MASS AND FUNCTION FOLLOWING TRANSPLANTATION","funder_award_id":"R01DK058508","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W32020374","https://openalex.org/W117172317","https://openalex.org/W140093196","https://openalex.org/W167368066","https://openalex.org/W1559021450","https://openalex.org/W1644915246","https://openalex.org/W1754966016","https://openalex.org/W1766685154","https://openalex.org/W1783261331","https://openalex.org/W1830922069","https://openalex.org/W1913985823","https://openalex.org/W1958244357","https://openalex.org/W1967086988","https://openalex.org/W1968823870","https://openalex.org/W1971517152","https://openalex.org/W1973509357","https://openalex.org/W1980166477","https://openalex.org/W1991241185","https://openalex.org/W1992002046","https://openalex.org/W1992008474","https://openalex.org/W1997093700","https://openalex.org/W2004656052","https://openalex.org/W2008245136","https://openalex.org/W2023543654","https://openalex.org/W2025557773","https://openalex.org/W2052667261","https://openalex.org/W2072319961","https://openalex.org/W2078010354","https://openalex.org/W2089601750","https://openalex.org/W2093714762","https://openalex.org/W2104395802","https://openalex.org/W2105096335","https://openalex.org/W2117226055","https://openalex.org/W2118822326","https://openalex.org/W2127067216","https://openalex.org/W2127068865","https://openalex.org/W2139413381","https://openalex.org/W2139485566","https://openalex.org/W2141630881","https://openalex.org/W2146718650","https://openalex.org/W2154052554","https://openalex.org/W2314701087","https://openalex.org/W2337712593","https://openalex.org/W2410670672"],"related_works":["https://openalex.org/W1487416285","https://openalex.org/W4378220719","https://openalex.org/W2314701087","https://openalex.org/W2149237933","https://openalex.org/W2273276059","https://openalex.org/W1913985823","https://openalex.org/W2052755304","https://openalex.org/W2412318708","https://openalex.org/W87501499","https://openalex.org/W7101053924"],"abstract_inverted_index":{"Multiple":[0],"inositol":[1,18,25,30,123],"polyphosphate":[2],"phosphatase":[3],"(MIPP)":[4],"is":[5,114,147],"an":[6,49,86,98,179,201],"enzyme":[7],"that,":[8],"in":[9,53,97,168,182,207],"vitro,":[10],"has":[11],"the":[12,21,41,54,67,94,126,149,174,198,208],"interesting":[13],"property":[14],"of":[15,29,40,56,69,110,130,155,176,204],"degrading":[16],"higher":[17],"polyphosphates":[19],"to":[20,65,106,135,139,165],"Ca2+":[22,59,73,153,185,205],"second":[23],"messenger,":[24],"1,4,5-trisphosphate":[26],"(Ins(1,4,5)P3),":[27],"independently":[28],"lipid":[31],"breakdown.":[32],"We":[33],"hypothesized":[34],"that":[35,102,148],"a":[36,78,107,117,189],"truncated":[37],"cytosolic":[38],"form":[39],"largely":[42],"endoplasmic":[43],"reticulum-confined":[44],"MIPP":[45],"(cyt-MIPP)":[46],"could":[47],"represent":[48],"important":[50,180,202],"new":[51],"tool":[52,181],"investigation":[55],"Ins(1,4,5)P3-dependent":[57,184],"intracellular":[58,72],"homeostasis.":[60],"To":[61],"optimize":[62],"our":[63],"ability":[64],"judge":[66],"impact":[68],"cyt-MIPP":[70,103,177],"on":[71],"concentration":[74,194],"([Ca2+]i)":[75],"we":[76],"chose":[77],"poorly":[79],"responsive":[80],"beta-cell":[81],"line":[82],"(HIT":[83],"M2.2.2)":[84],"with":[85],"abnormally":[87],"low":[88,127],"[Ca2+]i.":[89,170],"Our":[90],"results":[91],"show":[92],"for":[93],"first":[95],"time":[96],"intact":[99],"mammalian":[100],"cell":[101],"expression":[104],"leads":[105],"significant":[108,118],"enhancement":[109],"Ins(1,4,5)P3":[111,193],"concentration.":[112],"This":[113],"achieved":[115],"without":[116],"interference":[119],"from":[120],"other":[121],"cyt-MIPP-derived":[122],"phosphates.":[124],"Furthermore,":[125],"basal":[128,169,196],"[Ca2+]i":[129],"these":[131],"cells":[132,158],"was":[133,159],"raised":[134],"normal":[136,150],"levels":[137],"(35":[138],"115":[140],"nm)":[141],"when":[142],"they":[143],"expressed":[144],"cyt-MIPP.":[145],"Noteworthy":[146],"feeble":[151],"glucose-induced":[152],"response":[154],"HIT":[156],"M2.2.2":[157],"enhanced":[160],"dramatically":[161],"by":[162],"mechanisms":[163],"related":[164],"this":[166],"increase":[167],"These":[171],"data":[172],"support":[173],"use":[175],"as":[178],"investigating":[183],"homeostasis":[186],"and":[187,195],"suggest":[188],"close":[190],"link":[191],"between":[192],"[Ca2+]i,":[197],"latter":[199],"being":[200],"modulator":[203],"signaling":[206],"pancreatic":[209],"beta-cell.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
