{"id":"https://openalex.org/W2095355641","doi":"https://doi.org/10.1002/stem.5530080722","title":"Preclinical studies on synergistic effects of IL-1, IL-3, G-CSF and GM-CSF in cynomolgus monkeys","display_name":"Preclinical studies on synergistic effects of IL-1, IL-3, G-CSF and GM-CSF in cynomolgus monkeys","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2095355641","doi":"https://doi.org/10.1002/stem.5530080722","mag":"2095355641","pmid":"https://pubmed.ncbi.nlm.nih.gov/1691245"},"language":"en","primary_location":{"id":"doi:10.1002/stem.5530080722","doi":"https://doi.org/10.1002/stem.5530080722","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.5530080722","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Cell Cloning","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083653204","display_name":"Dorothee Krumwieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105121","display_name":"Behringwerke (Germany)","ror":"https://ror.org/01647vc39","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210105121"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Krumwieh","raw_affiliation_strings":["Research Laboratories, Behringwerke AG, Marburg, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Behringwerke AG, Marburg, Federal Republic of Germany","institution_ids":["https://openalex.org/I4210105121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081188689","display_name":"Ernst Weinmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105121","display_name":"Behringwerke (Germany)","ror":"https://ror.org/01647vc39","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210105121"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. Weinmann","raw_affiliation_strings":["Research Laboratories, Behringwerke AG, Marburg, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Behringwerke AG, Marburg, Federal Republic of Germany","institution_ids":["https://openalex.org/I4210105121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039457455","display_name":"BERNHARD SIEBOLD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105121","display_name":"Behringwerke (Germany)","ror":"https://ror.org/01647vc39","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210105121"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Siebold","raw_affiliation_strings":["Research Laboratories, Behringwerke AG, Marburg, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Behringwerke AG, Marburg, Federal Republic of Germany","institution_ids":["https://openalex.org/I4210105121"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015867235","display_name":"F. R. Seller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105121","display_name":"Behringwerke (Germany)","ror":"https://ror.org/01647vc39","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210105121"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. R. Seller","raw_affiliation_strings":["Research Laboratories, Behringwerke AG, Marburg, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratories, Behringwerke AG, Marburg, Federal Republic of Germany","institution_ids":["https://openalex.org/I4210105121"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210105121"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":5.1153,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.96101151,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"8","issue":"S1","first_page":"229","last_page":"248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.042500000447034836,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9589999914169312},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cytokine-synergy","display_name":"cytokine synergy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.871999979019165},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/g0-phase","display_name":"G0 phase","score":0.5569999814033508},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7374496459960938},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5543314814567566},{"id":"https://openalex.org/C131665280","wikidata":"https://www.wikidata.org/wiki/Q14866169","display_name":"Interleukin 3","level":5,"score":0.5417649149894714},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.5299968123435974},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.5163199305534363},{"id":"https://openalex.org/C2779958370","wikidata":"https://www.wikidata.org/wiki/Q5711176","display_name":"Hematopoietic growth factor","level":4,"score":0.4886236786842346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4822569489479065},{"id":"https://openalex.org/C880424","wikidata":"https://www.wikidata.org/wiki/Q416030","display_name":"Colony-stimulating factor","level":4,"score":0.46307361125946045},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4568716585636139},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.44930604100227356},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44761428236961365},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4355444312095642},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.433319091796875},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.41673892736434937},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.41654330492019653},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36023077368736267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3268303871154785},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3204064667224884},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3167790472507477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22641226649284363},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.1564754843711853},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09544879198074341},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08787325024604797},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.08166545629501343},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.07616016268730164},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003115","descriptor_name":"Colony-Stimulating Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003115","descriptor_name":"Colony-Stimulating Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/stem.5530080722","doi":"https://doi.org/10.1002/stem.5530080722","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.5530080722","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Cell Cloning","raw_type":"journal-article"},{"id":"pmid:1691245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1691245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cell cloning","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W90009575","https://openalex.org/W340210421","https://openalex.org/W1500174031","https://openalex.org/W1539584528","https://openalex.org/W1565595794","https://openalex.org/W1973312385","https://openalex.org/W1974761303","https://openalex.org/W1975331230","https://openalex.org/W1981163610","https://openalex.org/W1993079524","https://openalex.org/W2017737576","https://openalex.org/W2027562868","https://openalex.org/W2031991725","https://openalex.org/W2049363137","https://openalex.org/W2049423476","https://openalex.org/W2050149613","https://openalex.org/W2052264823","https://openalex.org/W2053588100","https://openalex.org/W2068382284","https://openalex.org/W2071595697","https://openalex.org/W2076193506","https://openalex.org/W2085404352","https://openalex.org/W2097779050","https://openalex.org/W2158528246","https://openalex.org/W2263914605","https://openalex.org/W2272907111","https://openalex.org/W2278794586","https://openalex.org/W2338649218","https://openalex.org/W2409062727","https://openalex.org/W2410918592","https://openalex.org/W2422717905","https://openalex.org/W2429225057","https://openalex.org/W2436516065","https://openalex.org/W2763443042"],"related_works":["https://openalex.org/W2414380419","https://openalex.org/W2095217352","https://openalex.org/W349542552","https://openalex.org/W2071595697","https://openalex.org/W1503450484","https://openalex.org/W2032263468","https://openalex.org/W2073803600","https://openalex.org/W1554408816","https://openalex.org/W1565595794","https://openalex.org/W140664629"],"abstract_inverted_index":{"The":[0,150,206],"regulation":[1],"of":[2,11,31,71,84,97,126,129,140,160,193,204,208],"blood":[3,100],"cell":[4,101,119],"formation":[5,102],"is":[6,131,231],"mediated":[7],"by":[8,65,95,133,167],"a":[9,75,171],"group":[10],"polypeptides":[12],"classified":[13],"as":[14,21,23],"hematopoietic":[15,55,86,195],"growth":[16],"and":[17,41,82,142,212],"differentiation":[18,83],"factors.":[19],"Overlapping":[20],"well":[22],"distinct":[24],"functions":[25],"have":[26,92],"been":[27,51,63,93],"described":[28],"for":[29],"three":[30],"these":[32,72,90],"cytokines:":[33],"interleukin":[34,47],"3":[35],"(IL-3),":[36],"granulocyte-macrophage":[37],"colony-stimulating":[38,43],"factor":[39,44],"(GM-CSF)":[40],"granulocyte":[42],"(G-CSF).":[45],"Furthermore,":[46],"1":[48],"(IL-1)":[49],"has":[50,62],"shown":[52],"to":[53,180,216,223],"promote":[54],"regeneration":[56],"after":[57],"cytoreductive":[58],"drug":[59],"treatment.":[60],"Evidence":[61],"provided":[64],"in":[66,98,103,147,174,184,201,238],"vitro":[67,185],"studies":[68,96],"that":[69,109,187],"combinations":[70],"factors":[73],"exert":[74],"highly":[76],"synergistic":[77,225],"action":[78],"on":[79,117,210],"the":[80,190,202],"proliferation":[81],"committed":[85],"progenitor":[87],"cells.":[88,162],"Additionally,":[89],"findings":[91,186],"supported":[94],"vivo":[99],"nonhuman":[104],"primates.":[105],"We":[106],"report":[107],"here":[108],"IL-3":[110,130,138,168,209],"acts":[111],"synergistically":[112,157],"with":[113,227,240,243],"GM-CSF":[114,134,228,241],"or":[115,135,229,242],"G-CSF":[116,164,188,230,244],"myelocytic":[118,161,211],"development":[120,214],"only":[121,145],"if":[122],"an":[123],"administration":[124,152],"time":[125],"eight":[127],"days":[128,144],"followed":[132,166],"G-CSF.":[136],"Short-time":[137],"application":[139,236],"two":[141],"four":[143],"resulted":[146],"platelet":[148,175],"production.":[149],"reverse":[151],"schedule":[153],"did":[154,169],"not":[155],"show":[156],"enhanced":[158,246],"stimulation":[159],"However,":[163],"treatment":[165],"induce":[170],"two-fold":[172],"increase":[173],"numbers.":[176],"This":[177],"would":[178],"appear":[179],"confirm":[181],"previously":[182],"reported":[183],"shortens":[189],"G0":[191],"period":[192],"human":[194],"stem":[196],"cells,":[197],"which":[198],"subsequently":[199],"proliferate":[200],"presence":[203],"IL-3.":[205],"effects":[207],"megakaryocytic":[213],"seems":[215],"be":[217],"differently":[218],"regulated.":[219],"Whereas,":[220],"IL-1":[221],"failed":[222],"display":[224],"activity":[226],"sequentially":[232],"applied.":[233],"Only":[234],"simultaneous":[235],"either":[237],"combination":[239],"demonstrated":[245],"efficacy.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}