{"id":"https://openalex.org/W2095308239","doi":"https://doi.org/10.1016/j.ijrobp.2014.01.057","title":"Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam\u2013Generated Neutrons","display_name":"Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam\u2013Generated Neutrons","publication_year":2014,"publication_date":"2014-04-09","ids":{"openalex":"https://openalex.org/W2095308239","doi":"https://doi.org/10.1016/j.ijrobp.2014.01.057","mag":"2095308239","pmid":"https://pubmed.ncbi.nlm.nih.gov/24725699","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4298825"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijrobp.2014.01.057","doi":"https://doi.org/10.1016/j.ijrobp.2014.01.057","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2014.01.057","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ijrobp.2014.01.057","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113516156","display_name":"Leo E. Gerweck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leo E. Gerweck","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: lgerweck@mgh.harvard.edu","Department of Radiation Oncology Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: lgerweck@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Radiation Oncology Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021963513","display_name":"Peigen Huang","orcid":"https://orcid.org/0000-0002-3184-6493","observed_orcids":["https://orcid.org/0000-0002-3184-6493"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peigen Huang","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-3184-6493","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103204373","display_name":"Hsiao\u2010Ming Lu","orcid":"https://orcid.org/0000-0002-9560-6157","observed_orcids":["https://orcid.org/0000-0002-9560-6157"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsiao-Ming Lu","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-9560-6157","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037938903","display_name":"Harald Paganetti","orcid":"https://orcid.org/0000-0002-6257-2413","observed_orcids":["https://orcid.org/0000-0002-6257-2413"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harald Paganetti","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-6257-2413","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044590938","display_name":"Yenong Zhou","orcid":"https://orcid.org/0009-0006-5727-301X","observed_orcids":["https://orcid.org/0009-0006-5727-301X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yenong Zhou","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113516156"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":{"value":4130,"currency":"USD","value_usd":4130},"fwci":0.5339,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.72450169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"89","issue":"1","first_page":"161","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.4790000021457672},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7139999866485596},{"id":"https://openalex.org/keywords/fvb-mice","display_name":"FVB mice","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2781298738","wikidata":"https://www.wikidata.org/wiki/Q18041535","display_name":"Sobp","level":4,"score":0.947650134563446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8066824078559875},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.622979998588562},{"id":"https://openalex.org/C2780944729","wikidata":"https://www.wikidata.org/wiki/Q897227","display_name":"Bragg peak","level":3,"score":0.5630694627761841},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5405086874961853},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.49384981393814087},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.46779829263687134},{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.4609106183052063},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3661075830459595},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.35708922147750854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.306637167930603},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.10399565100669861},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06300395727157593}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009502","descriptor_name":"Neutrons","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061766","descriptor_name":"Proton Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ijrobp.2014.01.057","doi":"https://doi.org/10.1016/j.ijrobp.2014.01.057","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2014.01.057","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},{"id":"pmid:24725699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24725699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation oncology, biology, physics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4298825","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4298825","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Radiat Oncol Biol Phys","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/32435166","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:32435166","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ijrobp.2014.01.057","doi":"https://doi.org/10.1016/j.ijrobp.2014.01.057","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2014.01.057","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4005318613","display_name":"PROTON THERAPY RESEARCH AND TREATMENT CENTER","funder_award_id":"C06CA059267","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1496390158","https://openalex.org/W1561487807","https://openalex.org/W1580553744","https://openalex.org/W1689017988","https://openalex.org/W1964869017","https://openalex.org/W1977288570","https://openalex.org/W1977331820","https://openalex.org/W1982931175","https://openalex.org/W2010705625","https://openalex.org/W2017816297","https://openalex.org/W2024045701","https://openalex.org/W2025666947","https://openalex.org/W2030544564","https://openalex.org/W2049599028","https://openalex.org/W2061890372","https://openalex.org/W2067480632","https://openalex.org/W2072524042","https://openalex.org/W2083895500","https://openalex.org/W2084969255","https://openalex.org/W2086862863","https://openalex.org/W2098990836","https://openalex.org/W2100018419","https://openalex.org/W2108408315","https://openalex.org/W2120392388","https://openalex.org/W2132490386","https://openalex.org/W2139622309","https://openalex.org/W2139632747","https://openalex.org/W2141484369","https://openalex.org/W2163964555","https://openalex.org/W2164717698","https://openalex.org/W2165231688","https://openalex.org/W2178154850","https://openalex.org/W2324644731","https://openalex.org/W2766008769","https://openalex.org/W4321429314","https://openalex.org/W4321429326","https://openalex.org/W6950270294"],"related_works":["https://openalex.org/W2000064068","https://openalex.org/W2079675015","https://openalex.org/W2055844668","https://openalex.org/W2190809893","https://openalex.org/W1974595080","https://openalex.org/W2007015638","https://openalex.org/W1979491637","https://openalex.org/W1987212275","https://openalex.org/W2593736800","https://openalex.org/W1689017988"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"evaluate":[2],"the":[3,47,65,77,80,83,125,129,146,151,195,244,261],"life":[4,126,148],"span":[5,127,149],"and":[6,41,111,117,180,249,272],"risk":[7,161,199,262,288],"of":[8,13,67,79,97,113,128,133,138,141,150,162,176,192,200,211,215,229,235,247,263],"cancer":[9,116,165,175,202],"following":[10],"whole-body":[11],"exposure":[12],"mice":[14,86,134,152,171,216],"to":[15,64,82,135,206,217,278],"neutrons":[16,218,271],"generated":[17,219],"by":[18,153,208,220,232,285],"a":[19,57,68,136,187,209,221,226,233,239,250],"passively":[20],"scattered":[21],"clinical":[22,70,193],"spread-out":[23],"Bragg":[24],"peak":[25],"(SOBP)":[26],"proton":[27,71,142,222],"beam.":[28,72],"METHODS":[29],"AND":[30],"MATERIALS:":[31],"Three":[32],"hundred":[33],"young":[34],"adult":[35],"female":[36],"FVB/N":[37],"mice,":[38],"152":[39],"test":[40],"148":[42],"control,":[43],"were":[44,50,122],"entered":[45],"into":[46],"experiment.":[48],"Mice":[49],"placed":[51],"in":[52,166,238,243,254],"an":[53],"annular":[54],"cassette":[55],"around":[56],"cylindrical":[58],"phantom,":[59],"which":[60],"was":[61,87,92,172],"positioned":[62],"lateral":[63],"mid-SOBP":[66,81],"165-MeV,":[69],"The":[73,90,107,159,257],"average":[74],"distance":[75],"from":[76,164,268],"edge":[78],"conscious":[84],"active":[85],"21.5":[88],"cm.":[89],"phantom":[91],"irradiated":[93],"with":[94],"once-daily":[95],"fractions":[96],"25":[98],"Gy,":[99],"4":[100],"days":[101],"per":[102],"week,":[103],"for":[104,174,182],"6":[105,277],"weeks.":[106],"age":[108],"at":[109],"death":[110,114,163],"cause":[112],"(ie,":[115],"type":[118],"vs":[119],"noncancer":[120],"causes)":[121],"assessed":[123],"over":[124],"mice.":[130],"RESULTS:":[131],"Exposure":[132,214],"dose":[137,191,223],"600":[139],"Gy":[140,190],"beam-generated":[143],"neutrons,":[144],"reduced":[145],"median":[147],"4.2%":[154],"(Kaplan-Meier":[155],"cumulative":[156],"survival,":[157],"P=.053).":[158],"relative":[160],"neutron":[167,287],"exposed":[168],"versus":[169],"control":[170],"1.40":[173],"all":[177],"types":[178],"(P=.0006)":[179],"1.22":[181],"solid":[183,201,255,266],"cancers":[184,267],"(P=.09).":[185],"For":[186],"typical":[188,227,273],"60":[189],"protons,":[194],"observed":[196],"22%":[197],"increased":[198],"would":[203],"be":[204],"expected":[205],"decrease":[207],"factor":[210,234],"10.":[212],"CONCLUSIONS:":[213],"that":[224,260],"exceeds":[225],"course":[228],"radiation":[230],"therapy":[231],"10,":[236],"resulted":[237],"statistically":[240],"significant":[241,252],"increase":[242,253],"background":[245],"incidence":[246],"leukemia":[248],"marginally":[251],"cancer.":[256],"results":[258],"indicate":[259],"out-of-field":[264],"second":[265],"SOBP":[269],"proton-generated":[270],"treatment":[274],"schedules,":[275],"is":[276,283],"10":[279],"times":[280],"less":[281],"than":[282],"suggested":[284],"current":[286],"estimates.":[289]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
