{"id":"https://openalex.org/W2095288148","doi":"https://doi.org/10.3109/01902148.2011.620680","title":"Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury","display_name":"Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2095288148","doi":"https://doi.org/10.3109/01902148.2011.620680","mag":"2095288148","pmid":"https://pubmed.ncbi.nlm.nih.gov/22044313","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3406407"},"language":"en","primary_location":{"id":"doi:10.3109/01902148.2011.620680","doi":"https://doi.org/10.3109/01902148.2011.620680","is_oa":false,"landing_page_url":"https://doi.org/10.3109/01902148.2011.620680","pdf_url":null,"source":{"id":"https://openalex.org/S97217451","display_name":"Experimental Lung Research","issn_l":"0190-2148","issn":["0190-2148","1521-0499"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Lung Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3406407","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103453501","display_name":"\u00d6zlem Ural G\u00fcrkan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ozlem U. Gurkan","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103405763","display_name":"Chaoxia He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaoxia He","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037689663","display_name":"Rachel Zielinski","orcid":"https://orcid.org/0009-0001-4128-0542","observed_orcids":["https://orcid.org/0009-0001-4128-0542"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Zielinski","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025048132","display_name":"Hamid Rabb","orcid":"https://orcid.org/0000-0002-4761-1103","observed_orcids":["https://orcid.org/0000-0002-4761-1103"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamid Rabb","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038175129","display_name":"Landon Stuart King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Landon S. King","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051456112","display_name":"Jeffrey M. Dodd\u2010o","orcid":"https://orcid.org/0000-0001-8895-210X","observed_orcids":["https://orcid.org/0000-0001-8895-210X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey M. Dodd-o","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037088678","display_name":"Franco R. D\u2019Alessio","orcid":"https://orcid.org/0000-0002-3728-0064","observed_orcids":["https://orcid.org/0000-0002-3728-0064"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franco R. D'Alessio","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030622094","display_name":"Neil R. Aggarwal","orcid":"https://orcid.org/0000-0002-0922-8824","observed_orcids":["https://orcid.org/0000-0002-0922-8824"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Aggarwal","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049816789","display_name":"David B. Pearse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Pearse","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073911134","display_name":"Patrice M. Becker","orcid":"https://orcid.org/0000-0002-1170-8587","observed_orcids":["https://orcid.org/0000-0002-1170-8587"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrice M. Becker","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3325,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.88443067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"37","issue":"10","first_page":"575","last_page":"584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ventilator-associated-lung-injury","display_name":"ventilator-associated lung injury","score":0.996999979019165},{"id":"https://openalex.org/keywords/pulmonary-vascular-permeability","display_name":"pulmonary vascular permeability","score":0.9739999771118164},{"id":"https://openalex.org/keywords/two-hit-model","display_name":"two-hit model","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.949999988079071},{"id":"https://openalex.org/keywords/il-6-deficient-mice","display_name":"IL-6-deficient mice","score":0.7609999775886536},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8100000023841858},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6922552585601807},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.605806291103363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5363171696662903},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.5142692923545837},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5059143900871277},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47062280774116516},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43407493829727173},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.41946378350257874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41945773363113403},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3875918686389923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3653604984283447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2751729190349579},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.08716922998428345}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012122","descriptor_name":"Ventilators, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3109/01902148.2011.620680","doi":"https://doi.org/10.3109/01902148.2011.620680","is_oa":false,"landing_page_url":"https://doi.org/10.3109/01902148.2011.620680","pdf_url":null,"source":{"id":"https://openalex.org/S97217451","display_name":"Experimental Lung Research","issn_l":"0190-2148","issn":["0190-2148","1521-0499"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Lung Research","raw_type":"journal-article"},{"id":"pmid:22044313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22044313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental lung research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3406407","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3406407","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Exp Lung Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3406407","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3406407","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Exp Lung Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1405958442","display_name":null,"funder_award_id":"P50 HL-073994","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2750132360","display_name":"VENTILATOR ASSOCIATED LUNG INJURY: MOLECULAR APPROACHES","funder_award_id":"5p50hl073994-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7456796308","display_name":"Neuropilin-1 and VEGF-mediated pulmonary edema","funder_award_id":"R01HL083286","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1534580282","https://openalex.org/W1580184585","https://openalex.org/W1766556848","https://openalex.org/W1834852860","https://openalex.org/W1837446566","https://openalex.org/W1972086715","https://openalex.org/W1973533486","https://openalex.org/W1974400821","https://openalex.org/W1987099899","https://openalex.org/W1987150557","https://openalex.org/W1994885986","https://openalex.org/W1996129554","https://openalex.org/W2007125759","https://openalex.org/W2007547216","https://openalex.org/W2016519825","https://openalex.org/W2020912656","https://openalex.org/W2024681203","https://openalex.org/W2029327309","https://openalex.org/W2040737235","https://openalex.org/W2043734144","https://openalex.org/W2046950254","https://openalex.org/W2051338691","https://openalex.org/W2058864165","https://openalex.org/W2062082715","https://openalex.org/W2067761476","https://openalex.org/W2072839106","https://openalex.org/W2074187198","https://openalex.org/W2074936672","https://openalex.org/W2077726738","https://openalex.org/W2088081911","https://openalex.org/W2098932165","https://openalex.org/W2100664103","https://openalex.org/W2107264515","https://openalex.org/W2107309778","https://openalex.org/W2108182701","https://openalex.org/W2119615201","https://openalex.org/W2120550838","https://openalex.org/W2122641338","https://openalex.org/W2125416593","https://openalex.org/W2130158896","https://openalex.org/W2131337790","https://openalex.org/W2131819814","https://openalex.org/W2140500533","https://openalex.org/W2142130443","https://openalex.org/W2142914398","https://openalex.org/W2148588954","https://openalex.org/W2154210321","https://openalex.org/W2154923159","https://openalex.org/W2156613610","https://openalex.org/W2158453561","https://openalex.org/W2167045140","https://openalex.org/W2167663348","https://openalex.org/W2170697455","https://openalex.org/W2170749565","https://openalex.org/W2172129183","https://openalex.org/W2172638096","https://openalex.org/W2181956695","https://openalex.org/W2183803729","https://openalex.org/W2342050276","https://openalex.org/W2410614036","https://openalex.org/W2431960688","https://openalex.org/W2597070792","https://openalex.org/W4249208591"],"related_works":["https://openalex.org/W3011559983","https://openalex.org/W1837446566","https://openalex.org/W2541782532","https://openalex.org/W2156098713","https://openalex.org/W1984705347","https://openalex.org/W7168126540","https://openalex.org/W4389368421","https://openalex.org/W2994735878","https://openalex.org/W2607291091","https://openalex.org/W2085988441"],"abstract_inverted_index":{"To":[0],"test":[1],"the":[2,9,195],"hypothesis":[3],"that":[4],"interleukin-6":[5],"(IL-6)":[6],"contributes":[7],"to":[8,30,181,193],"development":[10],"of":[11,50,97,101,129,198],"ventilator-associated":[12],"lung":[13,51,62,86],"injury":[14,45],"(VALI),":[15],"IL-6-deficient":[16],"(IL6(-/-))":[17],"and":[18,55,57,72,88,92,109,135,146,149,158],"wild-type":[19],"control":[20],"(WT)":[21],"mice":[22,116,160],"received":[23],"intratracheal":[24],"hydrochloric":[25],"acid":[26],"followed":[27],"by":[28,48],"randomization":[29],"mechanical":[31],"ventilation":[32,39],"(MV":[33],"+":[34,163],"IT":[35,164],"HCl)":[36],"or":[37,186],"spontaneous":[38],"(IT":[40],"HCl).":[41],"After":[42],"4":[43],"hours,":[44],"was":[46,83],"assessed":[47],"estimation":[49],"lavage":[52,87,110,147],"protein":[53],"concentration":[54,82,125,137],"total":[56,148],"differential":[58,150],"cell":[59,66,151],"counts,":[60],"wet/dry":[61],"weight":[63],"ratio,":[64],"pulmonary":[65],"death,":[67],"histologic":[68],"inflammation":[69,139],"score":[70],"(LIS),":[71],"parenchymal":[73,142],"myeloperoxidase":[74],"(MPO)":[75],"concentration.":[76],"Vascular":[77],"endothelial":[78],"growth":[79],"factor":[80],"(VEGF)":[81],"measured":[84],"in":[85,105,114,173,176,200],"homogenate,":[89],"as":[90,117,141],"IL-6":[91,130,172,184],"stretch":[93],"both":[94],"regulate":[95],"expression":[96,185],"this":[98,177],"potent":[99],"mediator":[100],"permeability.":[102],"MV-induced":[103],"increases":[104],"alveolar":[106,133],"barrier":[107],"dysfunction":[108],"VEGF":[111,124,136],"were":[112,138],"attenuated":[113],"IL6(-/-)":[115,159],"compared":[118],"with":[119,183],"WT":[120,157],"controls,":[121],"whereas":[122],"tissue":[123],"increased.":[126],"The":[127],"effects":[128,197],"deletion":[131],"on":[132],"permeability":[134],"independent,":[140],"MPO":[143],"concentration,":[144],"LIS,":[145],"counts":[152],"did":[153],"not":[154],"differ":[155],"between":[156],"following":[161],"MV":[162,199],"HCl.":[165],"These":[166],"data":[167],"support":[168],"a":[169],"role":[170],"for":[171],"promoting":[174],"VALI":[175],"two-hit":[178],"model.":[179],"Strategies":[180],"interfere":[182],"signaling":[187],"may":[188],"represent":[189],"important":[190],"therapeutic":[191],"targets":[192],"limit":[194],"injurious":[196],"inflamed":[201],"lungs.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}