{"id":"https://openalex.org/W2095204376","doi":"https://doi.org/10.1097/qco.0b013e3282f1bec9","title":"Antifungal therapy for neonatal candidiasis","display_name":"Antifungal therapy for neonatal candidiasis","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2095204376","doi":"https://doi.org/10.1097/qco.0b013e3282f1bec9","mag":"2095204376","pmid":"https://pubmed.ncbi.nlm.nih.gov/17975409"},"language":"en","primary_location":{"id":"doi:10.1097/qco.0b013e3282f1bec9","doi":"https://doi.org/10.1097/qco.0b013e3282f1bec9","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qco.0b013e3282f1bec9","pdf_url":null,"source":{"id":"https://openalex.org/S67076826","display_name":"Current Opinion in Infectious Diseases","issn_l":"0951-7375","issn":["0951-7375","1080-7861","1473-6527"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107845445","display_name":"Theoklis E. Zaoutis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Theoklis Zaoutis","raw_affiliation_strings":["Department of Pediatrics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. zaoutis@email.chop.edu","Antimicrobial Stewardship Program, Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA","Department of Pediatrics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. zaoutis@email.chop.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Antimicrobial Stewardship Program, Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Pediatrics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071800632","display_name":"Thomas J. Walsh","orcid":"https://orcid.org/0000-0002-4142-8711","observed_orcids":["https://orcid.org/0000-0002-4142-8711"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J Walsh","raw_affiliation_strings":["Immunocompromised Host Section, Pediatic Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunocompromised Host Section, Pediatic Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107845445"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.4605,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.40659341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"6","first_page":"592","last_page":"597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-candidiasis","display_name":"neonatal candidiasis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/candidemia","display_name":"candidemia","score":0.8539999723434448},{"id":"https://openalex.org/keywords/antifungal-prophylaxis","display_name":"antifungal prophylaxis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.9369999766349792},{"id":"https://openalex.org/keywords/echinocandins","display_name":"echinocandins","score":0.9900000095367432},{"id":"https://openalex.org/keywords/azoles","display_name":"azoles","score":0.9700000286102295},{"id":"https://openalex.org/keywords/neonatal-intensive-care","display_name":"neonatal intensive care","score":0.7850000262260437},{"id":"https://openalex.org/keywords/extremely-low-birth-weight-infants","display_name":"extremely low birth weight infants","score":0.8650000095367432},{"id":"https://openalex.org/keywords/late-onset-sepsis","display_name":"late-onset sepsis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9472299218177795},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.7331218719482422},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6043795347213745},{"id":"https://openalex.org/C2780161414","wikidata":"https://www.wikidata.org/wiki/Q29887808","display_name":"Invasive candidiasis","level":4,"score":0.5763291716575623},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.23051556944847107},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.20869708061218262}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007363","descriptor_name":"Intensive Care Units, Neonatal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/qco.0b013e3282f1bec9","doi":"https://doi.org/10.1097/qco.0b013e3282f1bec9","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qco.0b013e3282f1bec9","pdf_url":null,"source":{"id":"https://openalex.org/S67076826","display_name":"Current Opinion in Infectious Diseases","issn_l":"0951-7375","issn":["0951-7375","1080-7861","1473-6527"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:17975409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17975409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in infectious diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W107278038","https://openalex.org/W1759807858","https://openalex.org/W1966569663","https://openalex.org/W1970328266","https://openalex.org/W1978728204","https://openalex.org/W1982789371","https://openalex.org/W1989728928","https://openalex.org/W1996236107","https://openalex.org/W2000701107","https://openalex.org/W2002373860","https://openalex.org/W2005530044","https://openalex.org/W2006876723","https://openalex.org/W2009918667","https://openalex.org/W2014906134","https://openalex.org/W2016673581","https://openalex.org/W2020044972","https://openalex.org/W2025397401","https://openalex.org/W2038870928","https://openalex.org/W2039413289","https://openalex.org/W2057357654","https://openalex.org/W2060628325","https://openalex.org/W2061186719","https://openalex.org/W2071158633","https://openalex.org/W2075517361","https://openalex.org/W2080848374","https://openalex.org/W2092125702","https://openalex.org/W2105124717","https://openalex.org/W2116359244","https://openalex.org/W2143687882","https://openalex.org/W2147069968","https://openalex.org/W2153668719","https://openalex.org/W2169662494","https://openalex.org/W2333825775","https://openalex.org/W4210983795","https://openalex.org/W4237324178"],"related_works":["https://openalex.org/W2066920574","https://openalex.org/W2320070997","https://openalex.org/W4238235710","https://openalex.org/W2054861527","https://openalex.org/W2048598008","https://openalex.org/W2035870927","https://openalex.org/W2089199919","https://openalex.org/W2083609793","https://openalex.org/W2041516285","https://openalex.org/W1538516848"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"This":[3],"review":[4],"focuses":[5],"on":[6],"recent":[7],"data":[8,157,171],"regarding":[9],"antifungal":[10,13,104,163],"prophylaxis":[11,75,139],"and":[12,36,64,74,120,138,155,161,169],"treatment":[14],"of":[15,26,48,76,95,103,179],"neonatal":[16,32,53,69,87,110,180],"candidiasis.":[17,181],"RECENT":[18],"FINDINGS:":[19],"Candida":[20],"species":[21],"are":[22,37,122,165],"the":[23,31,38,52,101,109],"leading":[24],"cause":[25],"invasive":[27],"fungal":[28],"infection":[29,132],"in":[30,51,86,108,134,146,149,167],"intensive":[33,54,88,111],"care":[34,55,89,112],"unit,":[35],"third":[39],"most":[40],"common":[41],"blood":[42],"culture":[43],"isolates":[44],"recovered":[45],"from":[46],"cases":[47],"late-onset":[49],"sepsis":[50],"unit.":[56],"Neonatal":[57,127],"candidemia":[58,107],"is":[59,129],"associated":[60],"with":[61,91],"significant":[62],"morbidity":[63],"mortality.":[65],"Risk":[66],"factors":[67],"for":[68,106,158],"candidiasis":[70,128,148],"have":[71],"been":[72,80,100,141],"elucidated,":[73],"high-risk":[77,150],"infants":[78,137],"has":[79,99,140],"found":[81],"to":[82,143],"be":[83,144],"effective,":[84],"particularly":[85],"units":[90],"a":[92,130],"high":[93],"incidence":[94],"candidemia.":[96],"Amphotericin":[97],"B":[98],"mainstay":[102],"therapy":[105],"unit":[113],"but":[114],"newer":[115,162],"agents":[116,164],"such":[117],"as":[118],"echinocandins":[119],"azoles":[121],"currently":[123],"being":[124],"evaluated.":[125],"SUMMARY:":[126],"serious":[131],"especially":[133],"extremely":[135],"low-birthweight":[136],"shown":[142],"effective":[145,177],"preventing":[147],"infants.":[151],"Newer":[152],"pharmacokinetic,":[153],"safety":[154],"efficacy":[156],"both":[159],"older":[160],"emerging":[166],"neonates,":[168],"these":[170],"may":[172],"help":[173],"us":[174],"achieve":[175],"more":[176],"management":[178]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}