{"id":"https://openalex.org/W2095138452","doi":"https://doi.org/10.1073/pnas.86.5.1553","title":"Positive and negative regulatory elements in the mouse albumin enhancer.","display_name":"Positive and negative regulatory elements in the mouse albumin enhancer.","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W2095138452","doi":"https://doi.org/10.1073/pnas.86.5.1553","mag":"2095138452","pmid":"https://pubmed.ncbi.nlm.nih.gov/2922398","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/286736"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.86.5.1553","doi":"https://doi.org/10.1073/pnas.86.5.1553","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.5.1553","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/286736","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008593691","display_name":"Roy S. Herbst","orcid":"https://orcid.org/0000-0003-2535-5847","observed_orcids":["https://orcid.org/0000-0003-2535-5847"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R S Herbst","raw_affiliation_strings":["Rockefeller University, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N Friedman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Friedman","raw_affiliation_strings":["Rockefeller University, New York, NY 10021","The Rockefeller University, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109092455","display_name":"James E. Darnell Jr.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J E Darnell","raw_affiliation_strings":["Rockefeller University, New York, NY 10021","The Rockefeller University, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018960832","display_name":"L E Babiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L E Babiss","raw_affiliation_strings":["Rockefeller University, New York, NY 10021","The Rockefeller University, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":5.6039,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.97262178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"86","issue":"5","first_page":"1553","last_page":"1557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/albumin-gene","display_name":"albumin gene","score":0.875},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.8360000252723694},{"id":"https://openalex.org/keywords/negative-regulatory-element","display_name":"negative regulatory element","score":0.6800000071525574},{"id":"https://openalex.org/keywords/positive-regulatory-element","display_name":"positive regulatory element","score":0.7950000166893005},{"id":"https://openalex.org/keywords/c-ebp","display_name":"C/EBP","score":0.8479999899864197},{"id":"https://openalex.org/keywords/liver-specific-transcription","display_name":"liver-specific transcription","score":0.7269999980926514},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tissue-specific-transcription-factors","display_name":"tissue-specific transcription factors","score":0.5720000267028809},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.5460000038146973},{"id":"https://openalex.org/keywords/spleen-extract","display_name":"spleen extract","score":0.6819999814033508},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.9512201547622681},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6484230756759644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.637846052646637},{"id":"https://openalex.org/C21784809","wikidata":"https://www.wikidata.org/wiki/Q17119097","display_name":"Enhancer RNAs","level":5,"score":0.6269498467445374},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6060723066329956},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5518473386764526},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4401538670063019},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4283137321472168},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.4275780916213989},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.23886370658874512},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23174512386322021},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22752299904823303},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20403537154197693},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.86.5.1553","doi":"https://doi.org/10.1073/pnas.86.5.1553","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.86.5.1553","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:286736","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/286736","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2922398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2922398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:286736","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/286736","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2741457236","display_name":null,"funder_award_id":"GM07739-09","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6352374031","display_name":null,"funder_award_id":"CA16006-16","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W55452206","https://openalex.org/W1507474576","https://openalex.org/W1558516755","https://openalex.org/W1562468599","https://openalex.org/W1766519911","https://openalex.org/W1785366854","https://openalex.org/W1833428991","https://openalex.org/W1917294477","https://openalex.org/W1968102722","https://openalex.org/W1968169556","https://openalex.org/W1987703174","https://openalex.org/W1993243592","https://openalex.org/W2002886319","https://openalex.org/W2003893812","https://openalex.org/W2004563262","https://openalex.org/W2028647823","https://openalex.org/W2038055250","https://openalex.org/W2048356148","https://openalex.org/W2049672602","https://openalex.org/W2072585523","https://openalex.org/W2076134621","https://openalex.org/W2093458878","https://openalex.org/W2102129370","https://openalex.org/W2126093778","https://openalex.org/W2129247865","https://openalex.org/W2134926960","https://openalex.org/W2139190596"],"related_works":["https://openalex.org/W1925053557","https://openalex.org/W7080485634","https://openalex.org/W1797540775","https://openalex.org/W1496934545","https://openalex.org/W2002886319","https://openalex.org/W2066215499","https://openalex.org/W1815280954","https://openalex.org/W1833428991","https://openalex.org/W1917294477","https://openalex.org/W4242393018"],"abstract_inverted_index":{"Most":[0],"enhancer":[1,34,59,109],"elements":[2,76],"so":[3],"far":[4,30],"described":[5],"are":[6],"comprised":[7],"of":[8,21,44,80,136,143],"multiple":[9],"DNA":[10],"binding":[11],"sites":[12],"for":[13,106],"proteins":[14],"that":[15,28,53,65,86,103,141],"act":[16],"to":[17,37,88],"increase":[18],"the":[19,29,74,78,81,89,99,126],"rate":[20],"transcription.":[22,154],"In":[23],"this":[24],"report":[25],"we":[26],"show":[27],"upstream":[31],"mouse":[32],"albumin":[33],"element":[35,60,91],"(-10.5":[36],"-8.5":[38],"kilobase":[39],"pairs)":[40],"is":[41,68,92,104,111],"a":[42,50,62,94,137,149],"composite":[43],"at":[45],"least":[46],"three":[47],"functional":[48],"regions:":[49],"negative":[51,82],"region":[52,64],"suppresses":[54],"an":[55,134],"otherwise":[56],"positive,":[57],"liver-specific":[58,108],"and":[61,116],"third":[63],"by":[66],"itself":[67],"inactive":[69],"but":[70],"in":[71,113,122],"conjunction":[72],"with":[73],"remaining":[75],"overrides":[77],"effect":[79],"region.":[83],"The":[84],"protein":[85,102,130,140],"binds":[87],"overriding":[90],"C/EBP,":[93],"liver-enriched":[95],"transcription":[96],"factor,":[97],"whereas":[98],"newly":[100],"identified":[101],"responsible":[105],"full":[107],"activity":[110],"found":[112],"HeLa":[114],"cell":[115],"spleen":[117],"extracts":[118,123],"as":[119,121],"well":[120],"prepared":[124],"from":[125],"liver.":[127],"This":[128],"latter":[129],"may":[131],"therefore":[132],"be":[133],"example":[135],"widely":[138],"distributed":[139],"because":[142],"cell-specific":[144],"modification":[145],"or":[146],"interaction":[147],"has":[148],"tissue-specific,":[150],"positive":[151],"action":[152],"on":[153]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}