{"id":"https://openalex.org/W2094925860","doi":"https://doi.org/10.1109/nems.2007.352195","title":"Attenuation of Cellular Inflammation Using Glucocorticoid-Functionalized Copolymers","display_name":"Attenuation of Cellular Inflammation Using Glucocorticoid-Functionalized Copolymers","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2094925860","doi":"https://doi.org/10.1109/nems.2007.352195","mag":"2094925860"},"language":"en","primary_location":{"id":"doi:10.1109/nems.2007.352195","doi":"https://doi.org/10.1109/nems.2007.352195","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2007.352195","pdf_url":null,"source":{"id":"https://openalex.org/S4393918698","display_name":"IEEE International Conference on Nano/Micro Engineered and Molecular Systems","issn_l":"2474-3747","issn":["2474-3747"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017426783","display_name":"Edward Kai\u2010Hua Chow","orcid":"https://orcid.org/0000-0002-3075-1898","observed_orcids":["https://orcid.org/0000-0002-3075-1898"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward K. Chow","raw_affiliation_strings":["The Department of Microbiology, Immunology, and Molecular, Genetics, University of California, Los Angeles, Los Angeles, CA, USA","Dept. of Microbiol., Immunology, & Molecular Genetics, California Univ., Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Microbiology, Immunology, and Molecular, Genetics, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dept. of Microbiol., Immunology, & Molecular Genetics, California Univ., Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019949606","display_name":"Erik D. Pierstorff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik Pierstorff","raw_affiliation_strings":["The Departments of Biomedical and Mechanical Engineering at, Northwestern University, Evanston, IL, USA","Departments of Biomedical and Mechanical Engineering, Northwestern University, Evanston, IL 60208 USA. email: e-pierstorff@northwestern.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Biomedical and Mechanical Engineering at, Northwestern University, Evanston, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Departments of Biomedical and Mechanical Engineering, Northwestern University, Evanston, IL 60208 USA. email: e-pierstorff@northwestern.edu","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002701262","display_name":"Genhong Cheng","orcid":"https://orcid.org/0000-0002-6713-2783","observed_orcids":["https://orcid.org/0000-0002-6713-2783"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Genhong Cheng","raw_affiliation_strings":["The Department of Microbiology, Immunology, and Molecular, Genetics, University of California, Los Angeles, Los Angeles, CA, USA","Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095 USA. email: genhongc@microbio.ucla.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Microbiology, Immunology, and Molecular, Genetics, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095 USA. email: genhongc@microbio.ucla.edu","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100812756","display_name":"Yu\u2010Chong Tai","orcid":"https://orcid.org/0000-0001-8529-106X","observed_orcids":["https://orcid.org/0000-0001-8529-106X"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Chong Tai","raw_affiliation_strings":["The Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA","Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125 USA. email: yctai@mems.caltech.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, 91125 USA. email: yctai@mems.caltech.edu","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014473511","display_name":"Dean Ho","orcid":"https://orcid.org/0000-0002-7337-296X","observed_orcids":["https://orcid.org/0000-0002-7337-296X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Ho","raw_affiliation_strings":["The Departments of Biomedical and Mechanical Engineering, Northwestern University, Evanston, IL, USA","Departments of Biomedical and Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA. phone: 847-467-0548; email: d-ho@northwestern.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Biomedical and Mechanical Engineering, Northwestern University, Evanston, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Departments of Biomedical and Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA. phone: 847-467-0548; email: d-ho@northwestern.edu","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3535,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.87249284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1039","last_page":"1043"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.972000002861023},{"id":"https://openalex.org/keywords/amphiphilic-block-copolymers","display_name":"amphiphilic block copolymers","score":0.9629999995231628},{"id":"https://openalex.org/keywords/interfacial-deposition","display_name":"interfacial deposition","score":0.7139999866485596},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.8930000066757202},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7269999980926514},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9399999976158142},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/implant-biocompatibility","display_name":"implant biocompatibility","score":0.7889999747276306},{"id":"https://openalex.org/keywords/anti-inflammatory-coatings","display_name":"anti-inflammatory coatings","score":0.5929999947547913},{"id":"https://openalex.org/keywords/antifouling","display_name":"antifouling","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.660926342010498},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.5751839876174927},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5711885690689087},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.519448459148407},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.5011692047119141},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49241364002227783},{"id":"https://openalex.org/C2779849746","wikidata":"https://www.wikidata.org/wiki/Q411955","display_name":"Polydimethylsiloxane","level":2,"score":0.48644185066223145},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36270463466644287},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.27450862526893616},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19311290979385376},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1697515845298767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11302924156188965},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09541025757789612},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/nems.2007.352195","doi":"https://doi.org/10.1109/nems.2007.352195","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nems.2007.352195","pdf_url":null,"source":{"id":"https://openalex.org/S4393918698","display_name":"IEEE International Conference on Nano/Micro Engineered and Molecular Systems","issn_l":"2474-3747","issn":["2474-3747"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems","raw_type":"proceedings-article"},{"id":"pmh:oai:authors.library.caltech.edu:76772","doi":null,"is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/76772/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W94944660","https://openalex.org/W1490815887","https://openalex.org/W1964013622","https://openalex.org/W1969245917","https://openalex.org/W1977665107","https://openalex.org/W1988396057","https://openalex.org/W1990387017","https://openalex.org/W2010548899","https://openalex.org/W2019871275","https://openalex.org/W2024461377","https://openalex.org/W2049703159","https://openalex.org/W2063750992","https://openalex.org/W2066338596","https://openalex.org/W2083726955","https://openalex.org/W2098684734","https://openalex.org/W2102379760","https://openalex.org/W2108049830","https://openalex.org/W2117944575","https://openalex.org/W2152168515","https://openalex.org/W2172055337"],"related_works":["https://openalex.org/W2172201423","https://openalex.org/W1979138479","https://openalex.org/W2050704721","https://openalex.org/W2124221887","https://openalex.org/W2088917724","https://openalex.org/W2533102687","https://openalex.org/W2081190482","https://openalex.org/W2077143866","https://openalex.org/W2591998172","https://openalex.org/W2020670773"],"abstract_inverted_index":{"This":[0,225],"work":[1],"has":[2],"demonstrated":[3],"the":[4,28,36,39,46,56,73,78,88,91,104,116,139,179,186,192,205,218],"functionalization":[5],"of":[6,12,24,35,45,58,66,77,90,118,123,126,165,188,239],"an":[7],"amphiphilic":[8],"diblock":[9],"copolymer,":[10],"comprised":[11,23],"polyethylene":[13],"oxide-polymethyl":[14],"methacrylate":[15],"(PEO-PMMA),":[16],"as":[17,19,63,110,136,138,156],"well":[18,137],"a":[20,64,111,124,163,229],"triblock":[21],"copolymer":[22,37,207],"polymethyloxazoline-polydimethylsiloxane-polymethyloxazoline(PMOXA-PDMS-PM":[25],"OXA)":[26],"with":[27,103,152,191,204],"dexamethasone":[29],"(Dex)":[30],"glucocorticoid":[31],"anti-inflammatory.":[32],"Interfacial":[33],"deposition":[34],"and":[38,42,195,237],"Dex":[40,212],"molecules":[41,197],"subsequent":[43],"transfer":[44],"hybrid":[47],"materials":[48],"to":[49,54,68,94,149,174,210,221,232],"solid":[50],"substrates":[51],"were":[52,101,208],"characterized":[53],"evaluate":[55],"potential":[57],"utilizing":[59],"this":[60,81],"composite":[61,99,226],"material":[62,82],"suppressor":[65],"cyto-inflammation":[67,223],"enhance":[69],"implant":[70,235],"biocompatibility.":[71],"Given":[72],"extremely":[74],"thin":[75],"dimensions":[76],"film":[79],"(~4nm),":[80],"would":[83],"have":[84],"negligible":[85],"impact":[86],"upon":[87],"size":[89],"coated":[92],"device":[93],"preclude":[95],"biological":[96],"stress.":[97],"The":[98],"films":[100],"interfaced":[102],"RAW264.7":[105],"murine":[106],"macrophages":[107,200],"which":[108,146],"served":[109],"model":[112],"cell":[113,176],"line":[114],"for":[115],"evaluation":[117],"nuclear":[119],"factor-kappaB":[120],"(NF-KB)-induced":[121],"production":[122],"host":[125],"inflammatory":[127],"cytokines":[128,194],"including":[129],"interleukin-6,":[130],"interleukin-12,":[131],"tumor":[132],"necrosis":[133],"factor-alpha":[134],"(TNFalpha),":[135],"inducible":[140],"nitric":[141],"oxide":[142],"synthase":[143],"signaling":[144,196],"factor":[145],"is":[147,162],"known":[148],"be":[150],"involved":[151],"stress-related":[153],"processes":[154],"such":[155],"neuronal":[157],"damage.":[158],"Lipopolysaccharide":[159],"or":[160],"LPS":[161],"component":[164],"bacterial":[166],"membranes":[167],"that":[168,199,213],"elicits":[169],"cellular":[170],"stress":[171,181],"following":[172],"application":[173],"RAW":[175],"cultures.":[177],"Following":[178],"induced":[180],"response,":[182],"significant":[183],"reductions":[184],"in":[185,201],"expression":[187],"genes":[189],"associated":[190],"aforementioned":[193],"indicated":[198],"direct":[202],"contact":[203],"functionalized":[206],"able":[209],"collect":[211],"was":[214],"released":[215],"from":[216],"within":[217],"polymer":[219],"network":[220],"attenuate":[222],"mechanisms.":[224],"membrane":[227],"represents":[228],"medically-relevant":[230],"technology":[231],"promote":[233],"chronic":[234],"functionality":[236],"preclusion":[238],"bio-fouling.":[240]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}