{"id":"https://openalex.org/W2094925535","doi":"https://doi.org/10.1097/hco.0000000000000160","title":"Genetics of common forms of heart failure","display_name":"Genetics of common forms of heart failure","publication_year":2015,"publication_date":"2015-03-13","ids":{"openalex":"https://openalex.org/W2094925535","doi":"https://doi.org/10.1097/hco.0000000000000160","mag":"2094925535","pmid":"https://pubmed.ncbi.nlm.nih.gov/25768955","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4406340"},"language":"en","primary_location":{"id":"doi:10.1097/hco.0000000000000160","doi":"https://doi.org/10.1097/hco.0000000000000160","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hco.0000000000000160","pdf_url":null,"source":{"id":"https://openalex.org/S57372075","display_name":"Current Opinion in Cardiology","issn_l":"0268-4705","issn":["0268-4705","1080-787X","1531-7080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cardiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4406340","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christoph D. Rau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph D. Rau","raw_affiliation_strings":["aDepartment of Anesthesiology, Physiology and Medicine, Cardiovascular Research Laboratories bDepartment of Human Genetics, Microbiology and Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA","Department of Anesthesiology, Physiology and Medicine, Cardiovascular Research Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Anesthesiology, Physiology and Medicine, Cardiovascular Research Laboratories bDepartment of Human Genetics, Microbiology and Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Anesthesiology, Physiology and Medicine, Cardiovascular Research Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024741961","display_name":"Aldons Jake Lusis","orcid":"https://orcid.org/0000-0001-9013-0228","observed_orcids":["https://orcid.org/0000-0001-9013-0228"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aldons J. Lusis","raw_affiliation_strings":["Department of Human Genetics, Microbiology and Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Microbiology and Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100710570","display_name":"Yibin Wang","orcid":"https://orcid.org/0000-0003-0852-0767","observed_orcids":["https://orcid.org/0000-0003-0852-0767","https://orcid.org/0009-0004-8559-1619"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yibin Wang","raw_affiliation_strings":["Department of Anesthesiology, Physiology and Medicine, Cardiovascular Research Laboratories","to Yibin Wang, PhD, Division of Molecular Medicine, Department of Anesthesiology, University of California, Los Angeles, BH-569 CHS, Box 957115, Los Angeles, CA 90095-7115, USA. Tel: +1 310 206 5197; fax: +1 310 206 5907; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","fax: +1 310 206 5907","to Yibin Wang, PhD, Division of Molecular Medicine, Department of Anesthesiology, University of California, Los Angeles, BH-569 CHS, Box 957115, Los Angeles, CA 90095-7115, USA. Tel: +1 310 206 5197"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Physiology and Medicine, Cardiovascular Research Laboratories","institution_ids":[]},{"raw_affiliation_string":"to Yibin Wang, PhD, Division of Molecular Medicine, Department of Anesthesiology, University of California, Los Angeles, BH-569 CHS, Box 957115, Los Angeles, CA 90095-7115, USA. Tel: +1 310 206 5197; fax: +1 310 206 5907; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 310 206 5907","institution_ids":[]},{"raw_affiliation_string":"to Yibin Wang, PhD, Division of Molecular Medicine, Department of Anesthesiology, University of California, Los Angeles, BH-569 CHS, Box 957115, Los Angeles, CA 90095-7115, USA. Tel: +1 310 206 5197","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100710570"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":0.6234,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.54960689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"3","first_page":"222","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8899999856948853},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.9739999771118164},{"id":"https://openalex.org/keywords/endophenotypes","display_name":"endophenotypes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/founder-populations","display_name":"founder populations","score":0.9919999837875366},{"id":"https://openalex.org/keywords/animal-models-of-heart-failure","display_name":"animal models of heart failure","score":0.9269999861717224},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9351629018783569},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5298939347267151},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3669049143791199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25943076610565186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1097/hco.0000000000000160","doi":"https://doi.org/10.1097/hco.0000000000000160","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hco.0000000000000160","pdf_url":null,"source":{"id":"https://openalex.org/S57372075","display_name":"Current Opinion in Cardiology","issn_l":"0268-4705","issn":["0268-4705","1080-787X","1531-7080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cardiology","raw_type":"journal-article"},{"id":"pmid:25768955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25768955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3818189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4406340","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4406340","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4406340","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Cardiol","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2d838235","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2d838235","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Opinion in Cardiology, vol 30, iss 3","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3818189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4406340","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3913564549","display_name":null,"funder_award_id":"HL114437","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G717676866","display_name":null,"funder_award_id":"HL123295","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7406982922","display_name":"Systems Approach to Unraveling the Genetic Basis of Heart Failure","funder_award_id":"R01HL114437","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G827569432","display_name":"A Systems Approach to Dissect Genetic Basis of Heart Failure","funder_award_id":"R01HL123295","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1821665499","https://openalex.org/W1964567907","https://openalex.org/W1973412379","https://openalex.org/W1976987687","https://openalex.org/W1990801176","https://openalex.org/W2001258453","https://openalex.org/W2019621794","https://openalex.org/W2025389038","https://openalex.org/W2025900960","https://openalex.org/W2046987165","https://openalex.org/W2047174402","https://openalex.org/W2050856345","https://openalex.org/W2054029926","https://openalex.org/W2055799305","https://openalex.org/W2057422206","https://openalex.org/W2079927753","https://openalex.org/W2087745549","https://openalex.org/W2090728254","https://openalex.org/W2091524862","https://openalex.org/W2099247625","https://openalex.org/W2101648125","https://openalex.org/W2107504749","https://openalex.org/W2110624042","https://openalex.org/W2115801316","https://openalex.org/W2120237634","https://openalex.org/W2121630812","https://openalex.org/W2126388596","https://openalex.org/W2127684760","https://openalex.org/W2128778077","https://openalex.org/W2131062132","https://openalex.org/W2134755636","https://openalex.org/W2135048894","https://openalex.org/W2135287165","https://openalex.org/W2141561295","https://openalex.org/W2150904206","https://openalex.org/W2159721740","https://openalex.org/W2283568724","https://openalex.org/W2335953978","https://openalex.org/W4211191293","https://openalex.org/W4235363364","https://openalex.org/W6703034578"],"related_works":["https://openalex.org/W2093579073","https://openalex.org/W2959476251","https://openalex.org/W3156759448","https://openalex.org/W2802181569","https://openalex.org/W7053288692","https://openalex.org/W3009550334","https://openalex.org/W4409210044","https://openalex.org/W2903633215","https://openalex.org/W2527045017","https://openalex.org/W2070259852"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"In":[3],"contrast":[4],"to":[5,17,40,72,75,93],"many":[6],"other":[7],"human":[8,107],"diseases,":[9],"the":[10,31,42,80,104],"use":[11],"of":[12,44,47,61,91,106],"genome-wide":[13],"association":[14],"studies":[15],"(GWAS)":[16],"identify":[18],"genes":[19],"for":[20],"heart":[21],"failure":[22],"(HF)":[23],"has":[24,70],"had":[25],"limited":[26],"success.":[27],"We":[28],"will":[29],"discuss":[30],"underlying":[32,82],"challenges":[33],"as":[34,36],"well":[35],"potential":[37],"new":[38],"approaches":[39],"understanding":[41],"genetics":[43,81],"common":[45],"forms":[46],"HF.":[48],"RECENT":[49],"FINDINGS:":[50],"Recent":[51],"research":[52],"using":[53,84],"intermediate":[54],"phenotypes,":[55],"more":[56],"detailed":[57],"and":[58,66,100],"quantitative":[59],"stratification":[60],"HF":[62,83,92,98,108],"symptoms,":[63],"founder":[64],"populations":[65],"novel":[67],"animal":[68],"models":[69],"begun":[71],"allow":[73],"researchers":[74],"make":[76],"headway":[77],"toward":[78],"explaining":[79],"GWAS":[85,109],"techniques.":[86],"SUMMARY:":[87],"By":[88],"expanding":[89],"analyses":[90],"improved":[94],"clinical":[95],"traits,":[96],"additional":[97],"classifications":[99],"innovative":[101],"model":[102],"systems,":[103],"intractability":[105],"should":[110],"be":[111],"ameliorated":[112],"significantly.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}