{"id":"https://openalex.org/W2094903382","doi":"https://doi.org/10.1293/tox.24.87","title":"Comparative Nephrotoxicity of Cisplatin and Nedaplatin:Mechanisms and Histopathological Characteristics","display_name":"Comparative Nephrotoxicity of Cisplatin and Nedaplatin:Mechanisms and Histopathological Characteristics","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2094903382","doi":"https://doi.org/10.1293/tox.24.87","mag":"2094903382","pmid":"https://pubmed.ncbi.nlm.nih.gov/22272048","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234610"},"language":"en","primary_location":{"id":"doi:10.1293/tox.24.87","doi":"https://doi.org/10.1293/tox.24.87","is_oa":true,"landing_page_url":"https://doi.org/10.1293/tox.24.87","pdf_url":"https://www.jstage.jst.go.jp/article/tox/24/2/24_2_87/_pdf","source":{"id":"https://openalex.org/S79134261","display_name":"Journal of Toxicologic Pathology","issn_l":"0914-9198","issn":["0914-9198","1881-915X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313143","host_organization_name":"Japanese Society of Toxicologic Pathology","host_organization_lineage":["https://openalex.org/P4310313143"],"host_organization_lineage_names":["Japanese Society of Toxicologic Pathology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/tox/24/2/24_2_87/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028399560","display_name":"Takeki Uehara","orcid":"https://orcid.org/0000-0002-5853-9426","observed_orcids":["https://orcid.org/0000-0002-5853-9426"]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeki Uehara","raw_affiliation_strings":["Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi & Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi & Co., Ltd","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009514473","display_name":"Jyoji Yamate","orcid":"https://orcid.org/0009-0002-5544-2925","observed_orcids":["https://orcid.org/0009-0002-5544-2925"]},"institutions":[{"id":"https://openalex.org/I15807432","display_name":"Osaka Prefecture University","ror":"https://ror.org/02cf1je33","country_code":"JP","type":"education","lineage":["https://openalex.org/I15807432","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jyoji Yamate","raw_affiliation_strings":["Department of Veterinary Pathology, Graduate School of Agriculture and Biological Science, Osaka Prefecture University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, Graduate School of Agriculture and Biological Science, Osaka Prefecture University","institution_ids":["https://openalex.org/I15807432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045893156","display_name":"Mikinori Torii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mikinori Torii","raw_affiliation_strings":["Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi & Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi & Co., Ltd","institution_ids":["https://openalex.org/I4210118477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113790569","display_name":"Toshiyuki Maruyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118477","display_name":"Shionogi (Japan)","ror":"https://ror.org/01v3bqg10","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210118477"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Maruyama","raw_affiliation_strings":["Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi & Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Evaluation, Drug Developmental Research Laboratories, Shionogi & Co., Ltd","institution_ids":["https://openalex.org/I4210118477"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4393,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.9151145,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"24","issue":"2","first_page":"87","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.05849999934434891,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nedaplatin","display_name":"nedaplatin","score":1.0},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.968999981880188},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.6790000200271606},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.9710000157356262},{"id":"https://openalex.org/keywords/molecular-pathogenesis","display_name":"molecular pathogenesis","score":0.859000027179718},{"id":"https://openalex.org/keywords/drug-induced-nephrotoxicity","display_name":"drug-induced nephrotoxicity","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2778203143","wikidata":"https://www.wikidata.org/wiki/Q6986146","display_name":"Nedaplatin","level":4,"score":0.9878300428390503},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.960708737373352},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8840444684028625},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5817995071411133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47508469223976135},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4036997854709625},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.39798983931541443},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.32687127590179443},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2929708957672119},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21926498413085938}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1293/tox.24.87","doi":"https://doi.org/10.1293/tox.24.87","is_oa":true,"landing_page_url":"https://doi.org/10.1293/tox.24.87","pdf_url":"https://www.jstage.jst.go.jp/article/tox/24/2/24_2_87/_pdf","source":{"id":"https://openalex.org/S79134261","display_name":"Journal of Toxicologic Pathology","issn_l":"0914-9198","issn":["0914-9198","1881-915X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313143","host_organization_name":"Japanese Society of Toxicologic Pathology","host_organization_lineage":["https://openalex.org/P4310313143"],"host_organization_lineage_names":["Japanese Society of Toxicologic Pathology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2268873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3234610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22272048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22272048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicologic pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3234610","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3234610/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Toxicol Pathol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.2923","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.2923","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/23/57/J_Toxicol_Pathol_2011_Jun_30_24(2)_87-94.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1293/tox.24.87","doi":"https://doi.org/10.1293/tox.24.87","is_oa":true,"landing_page_url":"https://doi.org/10.1293/tox.24.87","pdf_url":"https://www.jstage.jst.go.jp/article/tox/24/2/24_2_87/_pdf","source":{"id":"https://openalex.org/S79134261","display_name":"Journal of Toxicologic Pathology","issn_l":"0914-9198","issn":["0914-9198","1881-915X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313143","host_organization_name":"Japanese Society of Toxicologic Pathology","host_organization_lineage":["https://openalex.org/P4310313143"],"host_organization_lineage_names":["Japanese Society of Toxicologic Pathology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicologic Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2094903382.pdf","grobid_xml":"https://content.openalex.org/works/W2094903382.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W5401597","https://openalex.org/W26283963","https://openalex.org/W35147279","https://openalex.org/W40644723","https://openalex.org/W53968717","https://openalex.org/W67746198","https://openalex.org/W130472780","https://openalex.org/W1545966740","https://openalex.org/W1555938743","https://openalex.org/W1579881701","https://openalex.org/W1749117680","https://openalex.org/W1895339950","https://openalex.org/W1965003837","https://openalex.org/W1969299977","https://openalex.org/W1971492805","https://openalex.org/W1973063537","https://openalex.org/W1974836020","https://openalex.org/W1975324989","https://openalex.org/W1976754856","https://openalex.org/W1979086997","https://openalex.org/W1982768697","https://openalex.org/W1983134363","https://openalex.org/W1983965827","https://openalex.org/W1990181628","https://openalex.org/W2003623572","https://openalex.org/W2004418842","https://openalex.org/W2007633861","https://openalex.org/W2016693266","https://openalex.org/W2018596550","https://openalex.org/W2022316171","https://openalex.org/W2027994274","https://openalex.org/W2028778467","https://openalex.org/W2048501683","https://openalex.org/W2051150238","https://openalex.org/W2054998714","https://openalex.org/W2056567773","https://openalex.org/W2058078699","https://openalex.org/W2058129391","https://openalex.org/W2058285926","https://openalex.org/W2060123651","https://openalex.org/W2060499225","https://openalex.org/W2062655222","https://openalex.org/W2066820242","https://openalex.org/W2067746951","https://openalex.org/W2069707552","https://openalex.org/W2071568301","https://openalex.org/W2072898466","https://openalex.org/W2073545951","https://openalex.org/W2075395395","https://openalex.org/W2078144803","https://openalex.org/W2084939005","https://openalex.org/W2085056993","https://openalex.org/W2090414853","https://openalex.org/W2093544927","https://openalex.org/W2096515859","https://openalex.org/W2097279274","https://openalex.org/W2098650139","https://openalex.org/W2099115268","https://openalex.org/W2106652794","https://openalex.org/W2114706859","https://openalex.org/W2117521967","https://openalex.org/W2119983127","https://openalex.org/W2121619348","https://openalex.org/W2140558175","https://openalex.org/W2157388811","https://openalex.org/W2159229915","https://openalex.org/W2170106455","https://openalex.org/W2171062114","https://openalex.org/W2407304462","https://openalex.org/W2408710509","https://openalex.org/W2415462524","https://openalex.org/W4251149346","https://openalex.org/W4252764622"],"related_works":["https://openalex.org/W7095610204","https://openalex.org/W2056567773","https://openalex.org/W117568422","https://openalex.org/W2339664892","https://openalex.org/W2031326183","https://openalex.org/W2494242206","https://openalex.org/W1995830747","https://openalex.org/W2428181822","https://openalex.org/W2012930931","https://openalex.org/W2020519239"],"abstract_inverted_index":{"The":[0],"antineoplastic":[1,84],"platinum":[2,33,85],"complexes":[3],"cisplatin":[4,96],"and":[5,20,62,79,97],"its":[6],"analogues":[7],"are":[8,21],"widely":[9],"used":[10],"in":[11,99],"the":[12,60,76,92],"chemotherapy":[13],"of":[14,17,27,48,95],"a":[15,31,46,88],"variety":[16],"human":[18],"malignancies,":[19],"especially":[22],"active":[23],"against":[24],"several":[25],"types":[26],"cancers.":[28],"Nedaplatin":[29],"is":[30],"second-generation":[32],"complex":[34],"with":[35,66,87],"reduced":[36],"nephrotoxicity.":[37,68],"However,":[38],"their":[39],"use":[40],"commonly":[41],"causes":[42],"nephrotoxicity":[43,94],"due":[44],"to":[45],"lack":[47],"tumor":[49],"tissue":[50],"selectivity.":[51],"Several":[52],"recent":[53],"studies":[54],"have":[55],"provided":[56],"significant":[57],"insights":[58],"into":[59],"molecular":[61,80],"histopathological":[63],"events":[64],"associated":[65],"nedaplatin":[67,98],"In":[69],"this":[70],"review,":[71],"we":[72],"summarize":[73],"findings":[74],"concerning":[75],"renal":[77],"histopathology":[78],"pathogenesis":[81],"induced":[82],"by":[83],"complexes,":[86],"particular":[89],"focus":[90],"on":[91],"comparative":[93],"rats.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}