{"id":"https://openalex.org/W2094884044","doi":"https://doi.org/10.1002/ijc.21862","title":"The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer","display_name":"The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer","publication_year":2006,"publication_date":"2006-02-27","ids":{"openalex":"https://openalex.org/W2094884044","doi":"https://doi.org/10.1002/ijc.21862","mag":"2094884044","pmid":"https://pubmed.ncbi.nlm.nih.gov/16506206"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.21862","doi":"https://doi.org/10.1002/ijc.21862","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.21862","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068226450","display_name":"Cristina Bilbao","orcid":"https://orcid.org/0000-0002-4796-1445","observed_orcids":["https://orcid.org/0000-0002-4796-1445"]},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]},{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Cristina Bilbao","raw_affiliation_strings":["Burnham Institute for Medical Research, La Jolla, CA, USA","Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnham Institute for Medical Research, La Jolla, CA, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111873141","display_name":"Germ\u00e1n Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-4303-4097","observed_orcids":["https://orcid.org/0000-0002-4303-4097"]},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]},{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Germ\u00e1n Rodr\u00edguez","raw_affiliation_strings":["Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046175181","display_name":"Raquel Ram\u00edrez\u2010Moreno","orcid":"https://orcid.org/0000-0002-0351-9073","observed_orcids":["https://orcid.org/0000-0002-0351-9073"]},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]},{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Ram\u00edrez","raw_affiliation_strings":["Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111668643","display_name":"Orlando Falc\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Orlando Falc\u00f3n","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Hospital Universitario Materno-Infantil de Canarias, Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","Instituto Ginecolo\u0301gico Dr. Falco\u0301n, Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","Instituto Ginecol\u00f3gico Dr. Falc\u00f3n, Las Palmas de Gran Canaria, Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Hospital Universitario Materno-Infantil de Canarias, Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":[]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Instituto Ginecolo\u0301gico Dr. Falco\u0301n, Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":[]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Instituto Ginecol\u00f3gico Dr. Falc\u00f3n, Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110005202","display_name":"Laureano Le\u00f3n","orcid":"https://orcid.org/0009-0003-1742-0677","observed_orcids":["https://orcid.org/0009-0003-1742-0677"]},"institutions":[{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laureano Le\u00f3n","raw_affiliation_strings":["Department of Pathology, Hospital Universitario Materno-Infantil de Canarias, Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital Universitario Materno-Infantil de Canarias, Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":[]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006318724","display_name":"Ricardo Chirino","orcid":"https://orcid.org/0000-0002-5681-8931","observed_orcids":["https://orcid.org/0000-0002-5681-8931"]},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]},{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ricardo Chirino","raw_affiliation_strings":["Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108435966","display_name":"Juan F. Rivero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]},{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan F. Rivero","raw_affiliation_strings":["Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111668643","display_name":"Orlando Falc\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Orlando Falc\u00f3n","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Hospital Universitario Materno-Infantil de Canarias, Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","Instituto Ginecolo\u0301gico Dr. Falco\u0301n, Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Hospital Universitario Materno-Infantil de Canarias, Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":[]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Instituto Ginecolo\u0301gico Dr. Falco\u0301n, Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":[]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075906592","display_name":"Bonifacio Nicol\u00e1s D\u00edaz-Chico","orcid":"https://orcid.org/0000-0001-5633-6185","observed_orcids":["https://orcid.org/0000-0001-5633-6185"]},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]},{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"B. Nicol\u00e1s D\u00edaz\u2010Chico","raw_affiliation_strings":["Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075066333","display_name":"Juan Carlos D\u00edaz-Chico","orcid":"https://orcid.org/0000-0002-0944-990X","observed_orcids":["https://orcid.org/0000-0002-0944-990X"]},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]},{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Juan C. D\u00edaz\u2010Chico","raw_affiliation_strings":["Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","Juan C. Di\u0301az-Chico, Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, PO Box 550, 35080 Las Palmas de Gran Canaria, Canary Islands, Spain","Manuel Perucho, Burnham Institute for Medical Research, La Jolla, CA 92037, USA","Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","Juan C. D\u00edaz-Chico, Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, PO Box 550, 35080 Las Palmas de Gran Canaria, Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Physiology, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigacio\u0301n del Ca\u0301ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Juan C. Di\u0301az-Chico, Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, PO Box 550, 35080 Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]},{"raw_affiliation_string":"Manuel Perucho, Burnham Institute for Medical Research, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Endometrial Cancer Study Group, Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), Canary Islands, Spain","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Juan C. D\u00edaz-Chico, Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, PO Box 550, 35080 Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035639497","display_name":"Manuel Perucho","orcid":"https://orcid.org/0000-0002-2169-2662","observed_orcids":["https://orcid.org/0000-0002-2169-2662"]},"institutions":[{"id":"https://openalex.org/I119635470","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464","country_code":"ES","type":"education","lineage":["https://openalex.org/I119635470"]},{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Manuel Perucho","raw_affiliation_strings":["Burnham Institute for Medical Research, La Jolla, CA, USA","Juan C. Di\u0301az-Chico, Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, PO Box 550, 35080 Las Palmas de Gran Canaria, Canary Islands, Spain","Manuel Perucho, Burnham Institute for Medical Research, La Jolla, CA 92037, USA","Juan C. D\u00edaz-Chico, Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, PO Box 550, 35080 Las Palmas de Gran Canaria, Canary Islands, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnham Institute for Medical Research, La Jolla, CA, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Juan C. Di\u0301az-Chico, Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, PO Box 550, 35080 Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]},{"raw_affiliation_string":"Manuel Perucho, Burnham Institute for Medical Research, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Juan C. D\u00edaz-Chico, Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, PO Box 550, 35080 Las Palmas de Gran Canaria, Canary Islands, Spain","institution_ids":["https://openalex.org/I119635470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035639497","https://openalex.org/A5075066333"],"corresponding_institution_ids":["https://openalex.org/I119635470","https://openalex.org/I188891513","https://openalex.org/I4210098709"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":6.5081,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.96986951,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"119","issue":"3","first_page":"563","last_page":"570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.8809999823570251},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pten-mutation","display_name":"PTEN mutation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mutation-spectrum","display_name":"mutation spectrum","score":0.6259999871253967},{"id":"https://openalex.org/keywords/allelic-imbalance","display_name":"allelic imbalance","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-suppressor-inactivation","display_name":"tumor suppressor inactivation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6729999780654907},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.5379999876022339},{"id":"https://openalex.org/keywords/endometrial-carcinogenesis","display_name":"endometrial carcinogenesis","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9795419573783875},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.902088463306427},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.6804447174072266},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6429442763328552},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6175995469093323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5920082330703735},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5052500367164612},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.49067723751068115},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4852449893951416},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47306716442108154},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47204291820526123},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.47084686160087585},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.42582768201828003},{"id":"https://openalex.org/C2780846426","wikidata":"https://www.wikidata.org/wiki/Q1138188","display_name":"Cowden syndrome","level":5,"score":0.41546571254730225},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.3735870122909546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3522202968597412},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3371662497520447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2078750729560852},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.05977928638458252},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.21862","doi":"https://doi.org/10.1002/ijc.21862","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.21862","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:16506206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16506206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4079554165","display_name":"MOLECULAR PATHOGENESIS OF CANCER OF MUTATOR PHENOTYPE","funder_award_id":"R37CA063585","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320323811","display_name":"Universidad de Las Palmas de Gran Canaria","ror":"https://ror.org/01teme464"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W82849906","https://openalex.org/W1493525469","https://openalex.org/W1499941079","https://openalex.org/W1509452950","https://openalex.org/W1513040830","https://openalex.org/W1565532031","https://openalex.org/W1569141172","https://openalex.org/W1570006151","https://openalex.org/W1580458764","https://openalex.org/W1592988859","https://openalex.org/W1593108703","https://openalex.org/W1614313922","https://openalex.org/W1644383846","https://openalex.org/W1658127082","https://openalex.org/W1768826340","https://openalex.org/W1854233595","https://openalex.org/W1911329982","https://openalex.org/W1946460195","https://openalex.org/W1964948442","https://openalex.org/W1965015655","https://openalex.org/W1965769128","https://openalex.org/W1970458969","https://openalex.org/W1973577899","https://openalex.org/W1975337974","https://openalex.org/W1977416006","https://openalex.org/W1978871519","https://openalex.org/W1984439054","https://openalex.org/W1986937402","https://openalex.org/W1988769784","https://openalex.org/W1993305625","https://openalex.org/W1995819860","https://openalex.org/W1996399533","https://openalex.org/W1999125576","https://openalex.org/W2009533359","https://openalex.org/W2011177813","https://openalex.org/W2011264036","https://openalex.org/W2017017512","https://openalex.org/W2020891498","https://openalex.org/W2034066784","https://openalex.org/W2039143308","https://openalex.org/W2039966201","https://openalex.org/W2041146525","https://openalex.org/W2041628146","https://openalex.org/W2044643325","https://openalex.org/W2050168543","https://openalex.org/W2054000192","https://openalex.org/W2055685287","https://openalex.org/W2057496292","https://openalex.org/W2068597536","https://openalex.org/W2072900847","https://openalex.org/W2073152187","https://openalex.org/W2074696167","https://openalex.org/W2076020247","https://openalex.org/W2076419143","https://openalex.org/W2076457965","https://openalex.org/W2080842507","https://openalex.org/W2084266051","https://openalex.org/W2092704893","https://openalex.org/W2104633297","https://openalex.org/W2105069515","https://openalex.org/W2110628116","https://openalex.org/W2113190292","https://openalex.org/W2121095159","https://openalex.org/W2125949119","https://openalex.org/W2126111731","https://openalex.org/W2130661390","https://openalex.org/W2132173772","https://openalex.org/W2134780780","https://openalex.org/W2136602069","https://openalex.org/W2141607880","https://openalex.org/W2146215003","https://openalex.org/W2152988906","https://openalex.org/W2154546296","https://openalex.org/W2155737059","https://openalex.org/W2155773826","https://openalex.org/W2156317352","https://openalex.org/W2156930691","https://openalex.org/W2160700807","https://openalex.org/W2161810908","https://openalex.org/W2163330492","https://openalex.org/W2165849599","https://openalex.org/W2167523886","https://openalex.org/W2169312351","https://openalex.org/W2247192901","https://openalex.org/W2343432753","https://openalex.org/W3147211624","https://openalex.org/W4255080289","https://openalex.org/W6635660723"],"related_works":["https://openalex.org/W2341152593","https://openalex.org/W2022257653","https://openalex.org/W1459603959","https://openalex.org/W2063530448","https://openalex.org/W2167523886","https://openalex.org/W2069051208","https://openalex.org/W2039966201","https://openalex.org/W2264841567","https://openalex.org/W2940652250","https://openalex.org/W2068597536"],"abstract_inverted_index":{"Microsatellite":[0],"instability":[1],"(MSI)":[2],"and":[3,61,77,98,223,261,280,285],"mutations":[4,63,90,159,166],"in":[5,15,26,40,55,66,72,131,137,167,174,192],"the":[6,11,59,111,115,168,183,242,250,259,262,268,273,282,288],"PTEN":[7,62,89,116,156,165,188,243],"gene":[8,117,244],"are":[9],"among":[10],"molecular":[12,38],"alterations":[13,206],"involved":[14],"endometrial":[16,50],"carcinogenesis.":[17],"There":[18,69],"is":[19],"conflicting":[20],"information":[21],"regarding":[22],"to":[23,128],"their":[24],"role":[25],"this":[27,32,277],"type":[28],"of":[29,45,58,88,102,107,114,122,145,152,185,213,265,270,272,287],"tumor.":[30],"For":[31],"reason,":[33],"we":[34],"have":[35],"studied":[36],"both":[37,84,204,258],"lesions":[39],"a":[41,85,99,225],"large":[42],"population-based":[43],"series":[44],"205":[46],"patients":[47,202,239],"with":[48,76,81,154,176,203,240],"sporadic":[49],"cancer.":[51],"MSI":[52,82,177,217],"was":[53,190],"found":[54,65,135],"41":[56],"(20.0%)":[57],"tumors":[60,75,140,153,175,195],"were":[64,70,134,171,207],"74":[67],"(36.1%).":[68],"differences":[71],"genotype":[73],"between":[74],"without":[78],"MSI.":[79],"Tumors":[80],"showed":[83],"higher":[86,100,191],"frequency":[87,260],"(58.5%":[91],"vs.":[92,119,142,179,197,218],"30.4%)":[93],"(p=0.002,":[94],"Fisher's":[95],"exact":[96],"test)":[97,237],"number":[101],"insertions":[103],"or":[104,160],"deletions":[105],"(I/D)":[106],"one":[108,271],"nucleotide":[109],"within":[110],"mononucleotide":[112],"tracts":[113],"(45.8%":[118],"11.4%":[120],"out":[121,144],"all":[123,146],"I/D,":[124],"p=0.005).":[125],"Conversely,":[126],"G:C":[127],"A:T":[129],"transitions":[130],"CpG":[132],"dinucleotides":[133],"mostly":[136],"microsatellite":[138,193],"stable":[139,194],"(57.7%":[141],"18.2%":[143],"single-base":[147],"substitutions,":[148],"p=0.037).":[149],"Overall,":[150],"67.6%":[151],"mutated":[155],"exhibited":[157,224],"multiple":[158],"allelic":[161],"imbalance":[162],"(AI).":[163],"Multiple":[164],"same":[169],"tumor":[170],"more":[172,210],"frequent":[173],"(60%":[178],"25.7%);":[180],"by":[181],"contrast":[182],"presence":[184],"AI":[186],"accompanying":[187],"mutation":[189],"(74.3%":[196],"40%)":[198],"(p=0.028).":[199],"In":[200],"addition,":[201],"genetic":[205],"diagnosed":[208],"at":[209],"advanced":[211],"stage":[212],"progression":[214],"(54.2%":[215],"for":[216,220],"20.0%":[219],"MSS,":[221],"p=0.006),":[222],"worse":[226],"prognosis":[227],"(hazard":[228],"ratio":[229],"[95%":[230],"confidence":[231],"interval]:":[232],"3.0":[233],"[1.1-13.1],":[234],"p=0.034,":[235],"log-rank":[236],"than":[238],"only":[241],"mutated.":[245],"Our":[246],"data":[247],"suggest":[248],"that":[249,275],"DNA":[251],"mismatch":[252],"repair":[253],"system":[254],"status":[255],"influences:":[256],"(i)":[257],"mutational":[263],"spectrum":[264],"PTEN;":[266],"(ii)":[267],"nature":[269],"hits":[274],"inactivate":[276],"tumor-suppressor":[278],"gene;":[279],"(iii)":[281],"clinical":[283],"condition":[284],"behavior":[286],"patients.":[289]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}