{"id":"https://openalex.org/W2094867151","doi":"https://doi.org/10.1016/j.ijpharm.2004.07.032","title":"Membrane permeability and antipyrine absorption in a rat model of ischemic colitis","display_name":"Membrane permeability and antipyrine absorption in a rat model of ischemic colitis","publication_year":2004,"publication_date":"2004-10-05","ids":{"openalex":"https://openalex.org/W2094867151","doi":"https://doi.org/10.1016/j.ijpharm.2004.07.032","mag":"2094867151","pmid":"https://pubmed.ncbi.nlm.nih.gov/15501001"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2004.07.032","doi":"https://doi.org/10.1016/j.ijpharm.2004.07.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2004.07.032","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089035003","display_name":"Kenjiro Koga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49155475","display_name":"Hokuriku University","ror":"https://ror.org/04wcpjy25","country_code":"JP","type":"education","lineage":["https://openalex.org/I49155475"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenjiro Koga","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan. k-koga@hokuriku-u.ac.jp","Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan. k-koga@hokuriku-u.ac.jp","institution_ids":["https://openalex.org/I49155475"]},{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan","institution_ids":["https://openalex.org/I49155475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070199609","display_name":"Yoshiro Ishitobi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49155475","display_name":"Hokuriku University","ror":"https://ror.org/04wcpjy25","country_code":"JP","type":"education","lineage":["https://openalex.org/I49155475"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiro Ishitobi","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan","institution_ids":["https://openalex.org/I49155475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086673855","display_name":"Susumu Kawashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49155475","display_name":"Hokuriku University","ror":"https://ror.org/04wcpjy25","country_code":"JP","type":"education","lineage":["https://openalex.org/I49155475"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Kawashima","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan","institution_ids":["https://openalex.org/I49155475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050717078","display_name":"Masakazu Taniguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405252479","display_name":"Japan Endocrine Society","ror":"https://ror.org/02f57qw79","country_code":"JP","type":"other","lineage":["https://openalex.org/I4405252479"]},{"id":"https://openalex.org/I4405276154","display_name":"SATO Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04xs11q41","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405276154"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakazu Taniguchi","raw_affiliation_strings":["Amato Pharmacetical Co., Kyoto 600-8813, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amato Pharmacetical Co., Kyoto 600-8813, Japan","institution_ids":["https://openalex.org/I4405252479","https://openalex.org/I4405276154"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045891920","display_name":"Masahiro Murakami","orcid":"https://orcid.org/0000-0001-5127-1714","observed_orcids":["https://orcid.org/0000-0001-5127-1714"]},"institutions":[{"id":"https://openalex.org/I4405252479","display_name":"Japan Endocrine Society","ror":"https://ror.org/02f57qw79","country_code":"JP","type":"other","lineage":["https://openalex.org/I4405252479"]},{"id":"https://openalex.org/I4405276154","display_name":"SATO Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04xs11q41","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405276154"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Murakami","raw_affiliation_strings":["Amato Pharmacetical Co., Kyoto 600-8813, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amato Pharmacetical Co., Kyoto 600-8813, Japan","institution_ids":["https://openalex.org/I4405252479","https://openalex.org/I4405276154"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":1.0702,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.76639822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"286","issue":"1-2","first_page":"41","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.24210000038146973,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.045899998396635056,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-colitis","display_name":"ischemic colitis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/antipyrine","display_name":"antipyrine","score":0.9100000262260437},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.8550000190734863},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.6259999871253967},{"id":"https://openalex.org/keywords/colonic-blood-flow","display_name":"colonic blood flow","score":0.6909999847412109},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9020000100135803},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/apparent-permeability-coefficient","display_name":"apparent permeability coefficient","score":0.7680000066757202},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7250000238418579},{"id":"https://openalex.org/keywords/rectal-drug-administration","display_name":"rectal drug administration","score":0.597000002861023},{"id":"https://openalex.org/keywords/ischemic-time","display_name":"ischemic time","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7522956132888794},{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.4652111828327179},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45608729124069214},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4293513298034668},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.423339307308197},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3688296675682068},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3662370443344116},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2622360289096832},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.17685019969940186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13799557089805603},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.11494538187980652}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000983","descriptor_name":"Antipyrine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017091","descriptor_name":"Colitis, Ischemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017091","descriptor_name":"Colitis, Ischemic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017091","descriptor_name":"Colitis, Ischemic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017392","descriptor_name":"Thiobarbituric Acid Reactive Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044683","descriptor_name":"Colon, Descending","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044683","descriptor_name":"Colon, Descending","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044683","descriptor_name":"Colon, Descending","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijpharm.2004.07.032","doi":"https://doi.org/10.1016/j.ijpharm.2004.07.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2004.07.032","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:15501001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15501001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335227","display_name":"Bijzonder Onderzoeksfonds UGent","ror":"https://ror.org/00cv9y106"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W187983981","https://openalex.org/W1972650262","https://openalex.org/W1983310681","https://openalex.org/W1993197679","https://openalex.org/W1996716971","https://openalex.org/W2008233272","https://openalex.org/W2019809671","https://openalex.org/W2026259404","https://openalex.org/W2037225189","https://openalex.org/W2061722163","https://openalex.org/W2079879922","https://openalex.org/W2086360535","https://openalex.org/W2087526401","https://openalex.org/W2092045246","https://openalex.org/W2096347909","https://openalex.org/W2118296121","https://openalex.org/W2129764344","https://openalex.org/W2144247614","https://openalex.org/W2148879813","https://openalex.org/W2156953890","https://openalex.org/W2286770866","https://openalex.org/W2287934268","https://openalex.org/W2411158403","https://openalex.org/W2473980270","https://openalex.org/W4391201338"],"related_works":["https://openalex.org/W1975336906","https://openalex.org/W2049857564","https://openalex.org/W1976583596","https://openalex.org/W2467850963","https://openalex.org/W2028729075","https://openalex.org/W2017377039","https://openalex.org/W2090900930","https://openalex.org/W2012437780","https://openalex.org/W1646212290","https://openalex.org/W18524193"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
